Bumetanide
- CAS No.
- 28395-03-1
- Chemical Name:
- Bumetanide
- Synonyms
- 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid;bumex;Lixil;pf159;DONALD;burine;pf1593;burinex;Bufenox;fontego
- CBNumber:
- CB9382992
- Molecular Formula:
- C17H20N2O5S
- Molecular Weight:
- 364.42
- MOL File:
- 28395-03-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:42
| Melting point | 230-2310C |
|---|---|
| Boiling point | 571.2±60.0 °C(Predicted) |
| Density | 1.2812 (rough estimate) |
| refractive index | 1.6510 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, soluble in acetone and in alcohol, slightly soluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides. |
| pka | pK1 3.6, pK2 7.7(at 25℃) |
| form | Solid |
| color | White to Light Yellow |
| Water Solubility | Soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetone, benzene, methanol, propylene glycol, and water (<1 mg/ml). |
| CAS DataBase Reference | 28395-03-1(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy- (28395-03-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DG4910000 | |||||||||
| HS Code | 2935904000 | |||||||||
| Toxicity | LD50 i.v. in mice: 330 mg/kg (Oestergaard) | |||||||||
| NFPA 704 |
|
Bumetanide price More Price(2)
Bumetanide Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Bumetanide is a diuretic.
Definition
ChEBI: A member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.
Biological Activity
Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. More potent than furosemide (5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid ).
Clinical Use
A diuretic structurally related to furosemide is bumetanide. This compound also functions as a high-ceiling diuretic in the ascending limb of the loop of Henle. It has a duration of action of approximately 4 hours. The uses of this compound are similar to those described for furosemide. The dose of bumetanide is 0.5 to 2 mg/day given as a single dose.
Bumetanide Preparation Products And Raw materials
Raw materials
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Global( 315)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Unichem Laboratories Ltd | +91-2266888333 +91-2266888333 | Maharashtra, India | 62 | 58 | Inquiry |
| Solara Active Pharma Sciences Ltd | +91-8046632100 +91-7075706520 | Bangalore, India | 65 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| Medilux Laboratories Pvt Ltd | +91-7292409991 +91-9819666688 | Madhya Pradesh, India | 102 | 58 | Inquiry |
| MSN LABORATORIES PRIVATE LTD | +91 40 30438600 | New Delhi, India | 230 | 58 | Inquiry |
| SOLARA ACTIVE PHARMA SCIENCES LTD | +91 44 4344 6700 | New Delhi, India | 89 | 58 | Inquiry |
| Unichem Laboratories Limited | +91 022 66 888 333 | New Delhi, India | 28 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
28395-03-1(Bumetanide)Related Search:
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3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-benzoicaci
3-(butylamino)-4-phenoxy-5-sulfamoyl-benzoicaci
3-Butyuamino-4-phenoxy-5-sutfamoylbenzoicacid
RO 10-6338
3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
3-(AMINOSULFONYL)-5-(BUTYLAMINO)-4-PHENOXYBENZOIC ACID
BUMETANIDE
bumex
burinex
BumetanideUSP
Bufenox
Lixil
Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-
Bumetanide (125 mg)
pf159
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3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid
Bumetanide,3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
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3-(AMinosulfonyl)-5-(butylaMino)-4-phenoxybenzoic acid, BuMex, Burinex
3-ButylaMino-4-phenoxy-5-sulfaMylbenzoic acid
DONALD
2-phenoxy-3-butylamino-5-carboxybenzenesulfonamide
Bumetanide Aminobenzoic Acid
Bumetanide iMpurity
Bemetanide
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Bisacodyl Solution, 100ppm
burine
fontego
fordiuran
lunetoron
pf1593
segurex
Bumetanide CRS
Bumetanide USP/EP/BP
Bumetanider
N-Nitroso Bumetanide
BumetanideQ: What is
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Bumetanide
Bumetanide (1078303)
Bumetanide/Ro10-6338/PF1593
3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid (Bumetanide Impurity)
Bumetanide
3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
28395-03-1
36442
Cell Signaling and Neuroscience
Cell Biology
BioChemical
Voltage-gated Ion Channels
Monovalent Ion Channels
Ion Channels
Ion Pump Inhibitors
Inhibitors
Ion transporter and other ion channel
Antibiotics
THIOPLEX
Aromatics Compounds
Aromatics