TOLBUTAMIDE
- CAS No.
- 64-77-7
- Chemical Name:
- TOLBUTAMIDE
- Synonyms
- Diaben;ORINASE;IRKG;d860;u2043;IRK16;GIRK4;BZ 55;D 860;tolbet
- CBNumber:
- CB4709039
- Molecular Formula:
- C12H18N2O3S
- Molecular Weight:
- 270.35
- MOL File:
- 64-77-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:09
| Melting point | 128-130°C |
|---|---|
| Density | 1.2450 |
| refractive index | 1.6360 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in chloroform. |
| form | Solid |
| pka | pKa 5.32(H2O t = 37) (Uncertain) |
| color | White to Off-White |
| Water Solubility | 0.14g/L(25 ºC) |
| Merck | 14,9507 |
| BRN | 1984428 |
| Specific Activity | 50-60 mCi/mmol |
| Concentration | 0.1 mCi/ml |
| Solvent | Ethanol |
| Stability | Stable. Combustible. |
| CAS DataBase Reference | 64-77-7(CAS DataBase Reference) |
| EPA Substance Registry System | Tolbutamide (64-77-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P261-P280g-P301+P312a-P321-P333+P313-P501a | |||||||||
| Hazard Codes | F,Xn | |||||||||
| Risk Statements | 20/21/22-40-43-36-11 | |||||||||
| Safety Statements | 26-36/37/39-36/37-16-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | YS4550000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 oral in rat: 2490mg/kg | |||||||||
| NFPA 704 |
|
TOLBUTAMIDE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T0891 | Tolbutamide analytical standard | 64-77-7 | 25G | ₹5001.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T0891 | Tolbutamide analytical standard | 64-77-7 | 100G | ₹10121.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T0891 | Tolbutamide analytical standard | 64-77-7 | 500G | ₹32128.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46968 | Tolbutamide VETRANAL?, analytical standard | 64-77-7 | 250MG | ₹4373.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3690 | Tolbutamide | 64-77-7 | 1G | ₹2600 | 2022-05-26 | Buy |
TOLBUTAMIDE Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Uses
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
Definition
ChEBI: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
General Description
Tolbutamide is N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide;or 1-butyl-3-(p-tolylsulfonyl)urea (Orinase,generic). Orinase Diagnostic was the sodium salt, which isfreely soluble in water for injection, but this product was discontinuedc. 2000.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
TOLBUTAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). TOLBUTAMIDE is incompatible with acids. .
Fire Hazard
Flash point data for TOLBUTAMIDE are not available. TOLBUTAMIDE is probably combustible.
Mechanism of action
Tolbutamide is one of the most widely used antidiabetic agents. Its action is preferably connected with stimulatory action of β-cells in the pancreas, which results in intensive insulin secretion.
Clinical Use
Tolbutamide should be used only when the diabetic patientis an adult or shows adult-onset diabetes, and the patientshould adhere to dietary restrictions.
Safety Profile
Moderately toxic by ingestion and several other routes. A human teratogen. Human reproductive effects by ingestion and possibly other routes: stillbirth, developmental abnormalities of the cardlovascular (circulatory) system and urogenital system, and unspecified neonatal effects. Human systemic effects by ingestion: nausea or vomiting, hypoglycemia. Other experimental teratogenic and reproductive effects. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NO, and SOx.
TOLBUTAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Kothari Phytochemicals and Industries Ltd. | +91-9244448844 +91-9331023407 | West Bengal, India | 18 | 58 | Inquiry |
| Bihani Chemical Industries Private Limited | +91-3322104586 +91-9831015305 | West Bengal, India | 12 | 58 | Inquiry |
| Quantum Drugs Chemicals | +91 9443396658 +91 9362944455 | Tamil Nadu, India | 6 | 58 | Inquiry |
| Rawia International HealthCare Pvt. Ltd. | 91-22-26425001 | Maharashtra, India | 170 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| KOTHARI PHYTOCHEMICALS INTERNATIONAL | +91 452 4392451/52/53 | New Delhi, India | 6 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |