Repaglinide
- CAS No.
- 135062-02-1
- Chemical Name:
- Repaglinide
- Synonyms
- PRANDIN;Repaglinide API;EP5.2;CS-1998;NOVONORM;AG-EE-623;ag-ee388zw;Repaglinid;Rapaglinide;Rebaglinide
- CBNumber:
- CB4140539
- Molecular Formula:
- C27H36N2O4
- Molecular Weight:
- 452.59
- MOL File:
- 135062-02-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/12 23:00:59
| Melting point | 129-130.2 °C |
|---|---|
| alpha | D20 +6.97° (c = 0.975 in methanol); D20 +7.45° (c = 1.06 in methanol) |
| Boiling point | 672.9±55.0 °C(Predicted) |
| Density | 1.137±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 34 mg/mL |
| form | solid |
| pka | 4.19±0.10(Predicted) |
| color | white |
| Water Solubility | 89.99mg/L(25 ºC) |
| Merck | 14,8136 |
| InChIKey | FAEKWTJYAYMJKF-QHCPKHFHSA-N |
| SMILES | C(O)(=O)C1=CC=C(CC(N[C@H](C2=CC=CC=C2N2CCCCC2)CC(C)C)=O)C=C1OCC |
| CAS DataBase Reference | 135062-02-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H361-H362 |
| Precautionary statements | P501-P263-P260-P270-P202-P201-P264-P280-P308+P313-P301+P312+P330-P405 |
| WGK Germany | 2 |
| RTECS | 000000033825 |
| HS Code | 2933399090 |
| Toxicity | LD50 orally in rats: >1 g/kg (Grell) |
Repaglinide price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R9028 | Repaglinide ≥98% (HPLC), solid | 135062-02-1 | 50MG | ₹19365.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R9028 | Repaglinide ≥98% (HPLC), solid | 135062-02-1 | 250MG | ₹83417.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3408 | Repaglinide pharmaceutical secondary standard, certified reference material | 135062-02-1 | 400MG | ₹20643.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | R0179 | Repaglinide | 135062-02-1 | 200MG | ₹8900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | R0179 | Repaglinide | 135062-02-1 | 1G | ₹16300 | 2022-05-26 | Buy |
Repaglinide Chemical Properties,Uses,Production
Description
Repaglinide was marketed in the US as an orally active hypoglycemic agent in patients with a type Ⅱ diabetes mellitus, to lower blood glucose in synergistic combination with metformin, when hyperglycemia cannot be controlled by diet, exercise or metformin alone. Chiral (S)-repaglinide can be synthesized in several ways, each involving a stereoselective reduction of an imine or enamine group. Repaglinide is a nonsulfonylurea belonging to the meglitinide family, with an insulin-releasing effect mediated by pancreatic betacells, by closing the ATP-sensitive K+ channels that, in turn, increases the cytosolic concentration of Ca++. In several animal models, repaglinide was more efficient than glibenclamide as a dose-dependant promoter of insulin release, but its mechanism of action is probably slightly different. Repaglinide has a rapid onset of action, a short duration of action and a reduced risk of hypoglycemia compared to glyburide.
Chemical Properties
White to Off-White Solid
Uses
The R-enantiomer showed only weak hypoglycemic activity. Repaglinide impurity
General Description
Repaglinide is 2-ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid(Prandin); approvals for generics are pending. Combinationsare available with metformin in the United States(Prandimet), and the drug may also be coprescribed with oneof the thiazolidinediones (typically pioglitazone or rosiglitazone;see previous discussion). To establish the most clinicallyvaluable dose, the patient is titrated while monitoringblood glucose levels and hemoglobin glycosylation (HbA1c)as an index of longer-term overall control.
Biological Activity
K ATP channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (K d = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo .
Clinical Use
Repaglinide is a nonsulfonylurea insulin secretagogue that was introduced in the United States in 1998 for type 2 diabetes.
Repaglinide Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| USV Pvt Ltd | +91-2267861111 +91-2225564048 | Maharashtra, India | 36 | 58 | Inquiry |
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd | +91-2242244224 +91-2243244324 | Maharashtra, India | 108 | 58 | Inquiry |
| Smilax Laboratories Limited | +91-8919514965 +91-8008333438 | Telangana, India | 28 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANWITA APIS | 58 |
| Dr. Reddy's Laboratories Ltd | 58 |
| USV Pvt Ltd | 58 |
| Aurobindo Pharma Limited | 58 |
| Hetero Drugs Limited | 58 |
| Macleods Pharmaceuticals Limited | 58 |
| Sun Pharmaceutical Industries Ltd | 58 |
| Smilax Laboratories Limited | 58 |
| HRV Global Life Sciences | 58 |
| Lakshmi Farmachem | 58 |