Glimepiride
- CAS No.
- 93479-97-1
- Chemical Name:
- Glimepiride
- Synonyms
- AMARYL;Glimpiride;GliMipride;N-(4-ethyl-3-methyl-5-oxo-2H-pyrrol-1-yl)-3-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]propanamide;amary;hoe490;Grimepride;glimepirid;GliMperide;Glenn urea
- CBNumber:
- CB8318552
- Molecular Formula:
- C24H34N4O5S
- Molecular Weight:
- 490.62
- MOL File:
- 93479-97-1.mol
- Modify Date:
- 2024/7/24 17:31:20
| Melting point | 212.2-214.5 °C |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >10 mg/mL |
| pka | 5.10±0.10(Predicted) |
| form | solid |
| color | white |
| Merck | 14,4440 |
| BCS Class | 2 |
| CAS DataBase Reference | 93479-97-1(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans- 4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo- (93479-97-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361 | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 21-36/38-46-62-63 | |||||||||
| Safety Statements | 25-26-36/37-53 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UX9363950 | |||||||||
| HS Code | 2935904000 | |||||||||
| NFPA 704 |
|
Glimepiride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1617 | Glimepiride Pharmaceutical Secondary Standard; Certified Reference Material | 93479-97-1 | 1G | ₹15966.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G2295 | Glimepiride ≥98% (HPLC), solid | 93479-97-1 | 50MG | ₹17060.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G2295 | Glimepiride ≥98% (HPLC), solid | 93479-97-1 | 250MG | ₹76283.78 | 2022-06-14 | Buy |
| TCI Chemicals (India) | G0395 | Glimepiride | 93479-97-1 | 1G | ₹8400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | G0395 | Glimepiride | 93479-97-1 | 5G | ₹11800 | 2022-05-26 | Buy |
Glimepiride Chemical Properties,Uses,Production
Description
Glimepiride, the first of a new generation of sulfonylurea drugs, was introduced in Sweden in 1995 as a first-line therapy to lower blood glucose in patients with type II diabetes. Sulfonylureas exert their hypoglycemic function primarily by direct stimulation of insulin secretion in glucose-insensitive pancreatic β-cells and GLUT translocation in insulin-resistant fat and muscle cells. Once-daily, orally administered glimepiride in diabetes patients showed a more rapid and longer lasting glucose-lowering effect than the commonly used agent glibenclamide. Glimepiride can be used either as a monotherapy or in combination with insulin.
Chemical Properties
White Cyrstalline Solid
Uses
Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.
General Description
Glimepiride is 3-ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]-carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide; thiscompound can also be named as the urea—see precedingdiscussion (Amaryl, generic). Combinations are availablewith rosiglitazone in the United States (Avandaryl tablets;mg glimepiride/mg rosiglitazone as maleate salt: 1/4,2/4, 4/4, 2/8, 4/8); and with pioglitazone (Duetact tablets;mg glimepiride/ mg pioglitazone as hydrochloride salt:2/30, 4/30).
Biological Activity
Potent K ATP channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K ATP channels with an IC 50 of 6.8 nM.
Glimepiride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| WARUKSHA LABORATORIES PVT LTD | +91-7485988764 +91-7485988764 | Gujarat, India | 77 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Hem-Deep Organics Pvt. Ltd. (HOPL) | +91-9998689897 +91-9824114578 | Gujarat, India | 12 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Nosch Labs Pvt Ltd | +91-4048557474 +91-9948222287 | Hyderabad, India | 58 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Dr. Reddy's Laboratories Ltd | 58 |
| J S LABS | 58 |
| SNECOFRi Pvt Ltd | 58 |
| WARUKSHA LABORATORIES PVT LTD | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Hem-Deep Organics Pvt. Ltd. (HOPL) | 58 |
| Ipca Laboratories Ltd | 58 |
| Hetero Drugs Limited | 58 |
| Macleods Pharmaceuticals Limited | 58 |
| Nosch Labs Pvt Ltd | 58 |
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