4-Methoxybenzoic acid
- CAS No.
- 100-09-4
- Chemical Name:
- 4-Methoxybenzoic acid
- Synonyms
- 4-Methoxybenzoic acid;ANISIC ACID;4-ANISIC ACID;P-METHOXYBENZOIC ACID;Anisic;4-METHOXYBENZOIC AICD;para-anisic acid;4-Methoxybenzoic;benzoicacid,4-methoxy-;p Acid
- CBNumber:
- CB6746524
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MOL File:
- 100-09-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/18 20:13:21
| Melting point | 182-185 °C(lit.) |
|---|---|
| Boiling point | 275 °C |
| Density | 1.385 |
| vapor pressure | 0.001Pa at 25℃ |
| FEMA | 3945 | 4-METHOXYBENZOIC ACID |
| refractive index | 1.571-1.576 |
| Flash point | 185 °C |
| storage temp. | Store below +30°C. |
| solubility | H2O: soluble2500 parts |
| form | Powder |
| pka | 4.50(at 25℃) |
| color | White to slightly gray-beige |
| PH | 3-4 (0.3g/l, H2O, 20℃) |
| Odor | at 10.00 % in dipropylene glycol. faint putrid sweet cadaverous |
| Odor Type | animal |
| Water Solubility | Soluble in water at 20°C 0.3g/L. Soluble in alcohol, ethyl acetate and ether. |
| Merck | 14,666 |
| JECFA Number | 883 |
| BRN | 508910 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | ZEYHEAKUIGZSGI-UHFFFAOYSA-N |
| LogP | 1.96 |
| CAS DataBase Reference | 100-09-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-methoxy-(100-09-4) |
| EPA Substance Registry System | Benzoic acid, 4-methoxy- (100-09-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338-P301+P312+P330 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | BZ4395000 | |||||||||
| Autoignition Temperature | 185 °C | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29189090 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg | |||||||||
| NFPA 704 |
|
4-Methoxybenzoic acid price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W394512 | p-Anisic acid natural, 99%, FG | 100-09-4 | 1SAMPLE-K | ₹5347.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W394512 | p-Anisic acid natural, 99%, FG | 100-09-4 | 100G | ₹8010.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W394512 | p-Anisic acid natural, 99%, FG | 100-09-4 | 1KG | ₹37411.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W394512 | p-Anisic acid natural, 99%, FG | 100-09-4 | 10KG | ₹233170.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W394505 | p-Anisic acid ≥99%, FG | 100-09-4 | 1SAMPLE | ₹4990.33 | 2022-06-14 | Buy |
4-Methoxybenzoic acid Chemical Properties,Uses,Production
Description
P-Anisic acid, also known as 4-Methoxybenzoic acid or draconic acid, is an organic acid that has a sweet flavor. It is one of the isomers of anisic acid, including m-anisic acid and o-anisic acid. The term "anisic acid" often refers to this form specifically. P-anisic acid is produced through the oxidation of p-cresyl-methyl ether.
Chemical Properties
It appears as a colorless needle crystal at room temperature. It is soluble in ethanol, ether, and chloroform, and only slightly soluble in hot water. It remains insoluble in cold water. It is used as an intermediate for aniracetam, as well as a preservative and fragrance.
Uses
4-Methoxybenzoic acid (p-Anisic acid) is used in oxidation and reduction of cytochrome c in solution through different self-assembled monolayers on gold electrodes using cyclic voltammetry. p-Anisic acid has antiseptic properties. It is also used as an intermediate in the preparation of more complex organic compounds.
Definition
ChEBI: 4-methoxybenzoic acid is a methoxybenzoic acid substituted with a methoxy group at position C-4. It has a role as a plant metabolite. It is functionally related to a benzoic acid. It is a conjugate acid of a 4-methoxybenzoate.
Preparation
To obtain 4-Methoxybenzoic acid, the mole ratio of cobalt and manganese is modified and p-methoxy toluene is reacted with oxygen or an oxygen-containing gas in the presence of acetic acid. The following is the experimental procedure:1. Using n-hexyl bromide, tri (n-hexyl) amine, para-methoxy toluene with cobalt chloride hexahydrate in about 9h;
2. By a catalytic oxidation process using p-methoxy toluene and propionic acid over a catalyst comprising of CoBr2.6H2O and MnBr2.4H2O with a reaction time of 20h;
3. Through changing the mole ratio of cobalt and manganese, using p-methoxy toluene with oxygen or oxygen containing gas in the presence of acetic acid to obtain the product.
General Description
4-Methoxybenzoic acid is the sole source of carbon and energy for growth in the cultures of Nocardia sp. DSM 1069. It is effective in clearing congestion in the lungs and the respiratory tracts in conditions like asthma or bronchitis.
Reactivity Profile
4-Methoxybenzoic acid belongs to Aromatic acid hydrazides (Others include isonicotinic, benzoic, and salicylic). The reaction of thiosemicarbazide and aromatic acid hydrazides with 4H-chromen-4-imines could prepare o-hydroxyphenyl derivatives of 1H-pyrazolethioamides and 1H-pyrazol-5-ylphenols derivatives[4].
Hazard
Thermal decomposition can lead to release of irritating gases and vapors, Carbon monoxide (CO), Carbon dioxide (CO2).
Biochem/physiol Actions
The cytochrome P450 enzyme CYP199A4, a heme-dependent cytochrome P450 (CYP) monooxygenase enzyme, can efficiently demethylate 4-methoxybenzoic acid. Mechanistically, O-demethylation of 4-methoxybenzoic acid occurs via hydrogen abstraction by Compound I, followed by oxygen rebound to give the hydroxylated hemiacetal which spontaneously decomposes to yield 4-hydroxybenzoic acid and formaldehyde[5].
Safety Profile
Poison by subcutaneous route.When heated to decomposition it emits acrid smoke andirritating vapors.
Solubility in organics
Soluble in alcohol and oils.
Purification Methods
Crystallise p-anisic acid from EtOH, water, EtOH/water or toluene. The S-benzylisothiuronium salt has m 189o (from EtOH). [Beilstein 10 II 91, 10 III 280, 10 IV 346.]
References
[1] Michael Ash (2004) Handbook of Preservatives
[2] Asim Kumar Mukhopadhyay (2004) Industrial Chemical Cresols and Downstream Derivatives
[3] https://en.wikipedia.org/wiki/P-Anisic_acid
[4] Zahorulko S, et al. Recyclization of 4 H -chromen-4-imine derivatives under the influence of dinucleophiles with the formation of functionally substituted pyrazoles. Monatshefte für Chemie - Chemical Monthly, 2019; 150: 1487–1493.
[5] Coleman T, et al. The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2016; 1864: 667-675.
4-Methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
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| chromsynth pvt ltd | 58 |
| SRI NICHOLAS FINECHEM LABORATORIES | 58 |
| ANJI BIOSCIENCES | 58 |
| sheetalchemicals | 58 |
| SREE SYNERIC LAB | 58 |
| JSK Chemicals | 58 |
| CNS CHEMICALS | 58 |
| Sintilla Medcoms Pvt Ltd | 58 |
| Riddhesh Pharmachem | 58 |
| Prash Intermediates | 58 |
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