4-Methoxybenzoyl chloride
- CAS No.
- 100-07-2
- Chemical Name:
- 4-Methoxybenzoyl chloride
- Synonyms
- P-ANISOYL CHLORIDE;ANISOYL CHLORIDE;4-methoxybenzoyl;P-METHOXYBENZOYL CHLORIDE;Anisoylchlorid;P-ANSIOYHLORIDE;P-anisoylcloride;AKOS BBS-00003907;4-ANISOYL CHLORIDE;4-Anisoylchloride99%
- CBNumber:
- CB8726991
- Molecular Formula:
- C8H7ClO2
- Molecular Weight:
- 170.59
- MOL File:
- 100-07-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/25 17:47:29
| Melting point | 22 °C(lit.) |
|---|---|
| Boiling point | 262-263 °C(lit.) |
| Density | 1.260 g/mL at 20 °C(lit.) |
| vapor pressure | 1.853Pa at 25℃ |
| refractive index |
n |
| Flash point | 190 °F |
| storage temp. | 2-8°C |
| form | Liquid After Melting |
| color | Clear colorless to brown |
| Odor | Sharp, penetrating. |
| Water Solubility | It reacts in water. |
| Sensitive | Moisture Sensitive |
| Merck | 14,673 |
| BRN | 471918 |
| Stability | Stable, but reacts violently with water. Ensure no moisture enters the container in which this material is stored, to prevent pressure build-up. Incompatible with water, moisture, strong bases, strong oxidizing agents. |
| InChIKey | MXMOTZIXVICDSD-UHFFFAOYSA-N |
| LogP | 1.52 |
| CAS DataBase Reference | 100-07-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Methoxybenzoic acid chloride(100-07-2) |
| EPA Substance Registry System | Benzoyl chloride, 4-methoxy- (100-07-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C,F | |||||||||
| Risk Statements | 14-34-67-65-63-48/20-11 | |||||||||
| Safety Statements | 26-36/37/39-45-62-16 | |||||||||
| RIDADR | UN 1729 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CA0270000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
4-Methoxybenzoyl chloride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A88476 | 4-Methoxybenzoyl chloride 99% | 100-07-2 | 5G | ₹2478.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A88476 | 4-Methoxybenzoyl chloride 99% | 100-07-2 | 25G | ₹2910 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A88476 | 4-Methoxybenzoyl chloride 99% | 100-07-2 | 100G | ₹21422.68 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M0721 | 4-Methoxybenzoyl Chloride min. 99.0 % | 100-07-2 | 25G | ₹3200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0721 | 4-Methoxybenzoyl Chloride min. 99.0 % | 100-07-2 | 100G | ₹11000 | 2022-05-26 | Buy |
4-Methoxybenzoyl chloride Chemical Properties,Uses,Production
Chemical Properties
4-methoxybenzoyl chloride appears as an amber-colored crystalline solid. Melting point 72 °F. Corrosive to metals and skin. Vapors may cause serious burns to the eyes. Decompose with water or alcohol, soluble in acetone and benzene.
Definition
The hydrolysis of 4-Methoxybenzoyl chloride (OMe) generally occurs through a dissociative mechanism (SN1). The reaction rate is strongly affected by the polarity of the medium and the ability to stabilize the leaving group. Water encapsulated within a reverse micellar system is less polar and less available compared to a continuous aqueous phase; Consequently, the hydrolysis of OMe in the micellar medium is slower than in pure water.
Application
4-Methoxybenzoyl chloride is one of the reactive acylating agents that can react with carboxylic acids, alcohols and amines to yield respective carboxylic anhydrides, esters and amides.
4-Methoxybenzoyl chloride can be used as radical precursor in visible-light photocatalysis to synthesize various heterocyclic compounds.
It can be used to synthesize acylphosphine ligands for the rhodium-catalyzed hydrosilylation of alkenes.
Incorporation of 4-methoxybenzoyl chloride modified indium tin oxide (ITO) as cathode for the fabrication of organic light-emitting diodes (OLEDs) has been reported.
1,3 diketones synthesized from 4-methoxybenzoyl chloride can be used in one pot synthesis of various pyrazole derivatives.
It can also be used in the total synthesis of bioactive compounds like echinoside A and salinosporamide A.
Synthesis
4-Methoxybenzoyl chloride is synthesized from the direct chlorination of 4-methoxybenzoic acid by thionyl chloride.
General Description
4-methoxybenzoyl chloride appears as an amber-colored crystalline solid. Melting point 72°F. Corrosive to metals and skin. Vapors may cause serious burns to the eyes.
Air & Water Reactions
Fumes in air. Reacts exothermically with water (including moisture in air or soil) to form hydrochloric acid and insoluble anisic acid [Merck 11th ed. 1989].
Reactivity Profile
ANISOYL CHLORIDE reacts exothermically with bases, including amines. Incompatible with water, strong oxidizing agents, alcohols. Sealed containers held at room temperature may explode, due to slow decomposition that builds up pressure. This situation is more dangerous with heat. May react vigorously or explosively with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Hazard
Solutions corrosive to tissue. Explosion risk when in closed containers due to pressure caused by decomposition at room temperature.
Health Hazard
Vapor irritates mucous membranes. Contact of liquid with eyes or skin causes severe irritation. Ingestion causes severe irritation of mouth and stomach.
Fire Hazard
Special Hazards of Combustion Products: Irritating hydrogen chloride fumes may be formed.
Chemical Reactivity
Reactivity with Water Reacts slowly to generate hydrogen chloride (hydrochloric acid). The reaction is not hazardous; Reactivity with Common Materials: Corrodes metal slowly; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Safety Profile
Corrosive to skin, eyes, mucous membranes, and other tissue.Evolves HCl by hydrolysis. A storage hazard; can explode spontaneously at room temperature. When heated to decomposition it emits toxic fumes of Cland may explode.
storage
Stored in a closed container can cause an explosion due to the pressure caused by decomposition, should be stored at low temperature (5°C).
Structure and conformation
Anisoyl chloride, also known as methoxybenzoyl chloride), is an acyl halide, specifically an aromatic acyl chloride, and may be formed from anisic acid by replacing a hydroxyl group of the carboxylic acid with a chloride group. There are three isomers: the ortho-, meta-, and para- forms. 4-Methoxybenzoyl chloride is para- forms. Their structures differ in the arene substitution pattern—the location of the methoxy group on the ring as compared to the acyl halide.
4-Methoxybenzoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| SURVIVAL TECHNOLOGIES LIMITED | 58 |
| JSK Chemicals | 58 |
| AVIGYABIOSCIENCES PRIVATE LIMITED | 58 |
| Shree Sulphurics Pvt Ltd (SSPL) | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| S D Fine Chem Limited | 58 |
| Ascent Finechem (P) Limited | 58 |
| Ethachem | 58 |
| P C Chem | 58 |
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