3-Amino-4-methoxybenzanilide
- CAS No.
- 120-35-4
- Chemical Name:
- 3-Amino-4-methoxybenzanilide
- Synonyms
- AMBA;AMAN;Red KD Base;Red based KD;FAST RED KD BASE;3-AMINO-P-ANISANILIDE;LABOTEST-BB LT01138545;4-Methoxy-3-aminobenzanilide;3-AMINO-4-METHOXYBENZANILIDE;3-amino-4-methoxy-benzanilid
- CBNumber:
- CB7251074
- Molecular Formula:
- C14H14N2O2
- Molecular Weight:
- 242.27
- MOL File:
- 120-35-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 154-156°C |
|---|---|
| Boiling point | 385.1°C (rough estimate) |
| Density | 1.1338 (rough estimate) |
| vapor pressure | 0-0Pa at 25℃ |
| refractive index | 1.6419 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 13.44±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| LogP | 2.08 at 23℃ and pH7 |
| CAS DataBase Reference | 120-35-4(CAS DataBase Reference) |
| EPA Substance Registry System | Benzamide, 3-amino-4-methoxy-N-phenyl- (120-35-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RTECS | CV7400000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2924297099 | |||||||||
| Toxicity | mouse,LD50,intravenous,320mg/kg (320mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01183, | |||||||||
| NFPA 704 |
|
3-Amino-4-methoxybenzanilide Chemical Properties,Uses,Production
Chemical Properties
Gray powder.
Uses
Dyes, pharmaceuticals, and other organic chemicals.
Synthesis
3-Amino-4-methoxybenzanilide is prepared by the reaction of 3-amino-4-methoxybenzoic acid and aniline. The steps are as follows:
A total of 0.17 mL (0.18 mmol) of DIC and 0.24 g (0.18 mmol) of HOBt were added to a dichloromethane solution of 0.20 g (0.12 mmol) of 1 at room temperature, and the reaction mixture was stirred for 0.5 h.
Then, 0.13 mL (0.14 mmol) of aniline was added to the mixture.
After approximately 3 h, 0.5 N NaOH was added to the solution.
The lower layer was isolated, and 0.5 N HCl was added until the aqueous solution was neutral.
The dichloromethane layer was washed three times with 10 mL of water, and then MgSO4 was added.
After 2 h, the solution was filtered, and the solvent was removed.
The residue was purified by column chromatography on silica gel (eluent: petroleum ether:ethyl acetate = 3:1) to yield the desired 3-Amino-4-methoxybenzanilide as a white solid (yield: 76%). Mp: 197-198 °C. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 9.92 (1H, s, NH), 7.74 (2H, d, J = 9.0 Hz, PhH), 7.32 (2H, m, PhH), 7.21 (2H, d, J = 8.0 Hz, PhH), 7.06 (1H, m, PhH), 6.88 (1H, d, J = 8.0 Hz, PhH), 4.90 (2H, br s, NH2), 3.83 (3H, s, OCH3). ESI-MS (m/z): 243 (M + H)+.
3-Amino-4-methoxybenzanilide Preparation Products And Raw materials
Raw materials
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| Americos Chemicals Pvt. Ltd. | 91-79-26447781 | Gujarat, India | 47 | 58 | Inquiry |
| Emco Dyestuff Pvt. Ltd. | +91 (22) 894 35 21 / 894 49 06 | New Delhi, India | 189 | 54 | Inquiry |
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