4'-Methoxyacetophenone
- CAS No.
- 100-06-1
- Chemical Name:
- 4'-Methoxyacetophenone
- Synonyms
- 4-METHOXYACETOPHENONE;ACETANISOLE;1-(4-METHOXYPHENYL)ETHANONE;4-ACETYLANISOLE;P-ACETYLANISOLE;Acetanisol;P-METHOXYACETOPHENONE;Ethanone, 1-(4-methoxyphenyl)-;Vananote;p-Acetoanisole
- CBNumber:
- CB1132155
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.17
- MOL File:
- 100-06-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/10 17:45:06
| Melting point | 36-38 °C (lit.) |
|---|---|
| Boiling point | 152-154 °C/26 mmHg (lit.) |
| Density | 1.08 |
| vapor pressure | 0.42Pa at 20℃ |
| refractive index | 1.5470 (estimate) |
| FEMA | 2005 | ACETANISOLE |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | H2O: soluble2.474g/L at 20°C |
| form | Crystals or Crystalline Powder |
| color | White |
| Odor | at 100.00 %. sweet hawthorn anisic powdery balsamic acacia |
| Odor Type | anisic |
| Water Solubility | insoluble |
| Sensitive | Light Sensitive |
| JECFA Number | 810 |
| BRN | 742313 |
| InChIKey | NTPLXRHDUXRPNE-UHFFFAOYSA-N |
| LogP | 1.79 at 20℃ |
| CAS DataBase Reference | 100-06-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetophenone, 4'-methoxy-(100-06-1) |
| EPA Substance Registry System | 4'-Methoxyacetophenone (100-06-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-38-36/38-20/21/22 | |||||||||
| Safety Statements | 37-37/39-26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AM9240000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145000 | |||||||||
| Toxicity | The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973). | |||||||||
| NFPA 704 |
|
4'-Methoxyacetophenone price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W200506 | Acetanisole ≥98%, FCC, FG | 100-06-1 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W200506 | Acetanisole ≥98%, FCC, FG | 100-06-1 | 1KG | ₹13195.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W200506 | Acetanisole ≥98%, FCC, FG | 100-06-1 | 5KG | ₹45724.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W200506 | Acetanisole ≥98%, FCC, FG | 100-06-1 | 25KG | ₹165849.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 117374 | 4′-Methoxyacetophenone 99% | 100-06-1 | 5G | ₹3110 | 2022-06-14 | Buy |
4'-Methoxyacetophenone Chemical Properties,Uses,Production
Chemical Properties
WHITE CRYSTALS OR CRYSTALLINE POWDER
Chemical Properties
Colorless crystals or fused crystalline/Yellowish-white crystals mass. with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors. Heavier than water, practically insoluble in water. Miscible with oils, soluble in alcohol, Relatively stable in soap and under similar, mild-alkaline conditions.
Occurrence
Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).
Uses
4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone.
Preparation
From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid in the presence of boron trifluoride.
Definition
ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4.
General Description
4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system.
Safety Profile
Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
Purification Methods
Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]
4'-Methoxyacetophenone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| chromsynth pvt ltd | +919704220374 | Hyderabad, India | 244 | 58 | Inquiry |
| Freesia Chemicals | +9102225689889 | Mumbai, India | 45 | 58 | Inquiry |
| SANIKA CHEMICALS PVT.LTD. | +91-8422919852 +91-8422919852 | Mumbai, India | 38 | 58 | Inquiry |
| NOVOCHEM INDUSTRIES PVT LTD | +91-9823022540 +91-9823022540 | New Delhi, India | 12 | 58 | Inquiry |
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Cefa-Cilinas Biotics Pvt Ltd | +91-7875033155 +91-8080701561 | Maharashtra, India | 121 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| chromsynth pvt ltd | 58 |
| Freesia Chemicals | 58 |
| SANIKA CHEMICALS PVT.LTD. | 58 |
| NOVOCHEM INDUSTRIES PVT LTD | 58 |
| Vardhaman P Golechha | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| AVD pharmaceuticals Pvt Ltd | 58 |
| JSK Chemicals | 58 |
| Cefa-Cilinas Biotics Pvt Ltd | 58 |