DOXEPIN
- CAS No.
- 1668-19-5
- Chemical Name:
- DOXEPIN
- Synonyms
- Aponal;p3693a;Curatin;Docepin;P-3693A;Quitaxon;Doxepine;NSC-108160;Doxepin-13C D3;DOXEPIN USP/EP/BP
- CBNumber:
- CB5113073
- Molecular Formula:
- C19H21NO
- Molecular Weight:
- 279.38
- MOL File:
- 1668-19-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Melting point | 187-189°C |
|---|---|
| Boiling point | bp0.03 154-157°; bp0.2 260-270° |
| Density | 1.0594 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| pka | 9.40±0.28(Predicted) |
| Water Solubility | 31.57mg/L(25 ºC) |
| EPA Substance Registry System | Doxepin (1668-19-5) |
SAFETY
Risk and Safety Statements
| Hazard Codes | T |
|---|---|
| Risk Statements | 25 |
| Safety Statements | 36/37/39-45 |
| Toxicity | LD50 in mice, rats (mg/kg): 26, 16 i.v.; 79, 182 i.p.; 135, 147 orally (Ribbentrop, Schaumann) |
DOXEPIN Chemical Properties,Uses,Production
Uses
Used clinically to treat anxiety and depression. Antidepressant
Definition
ChEBI: A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
World Health Organization (WHO)
Doxepin, a tricyclic antidepressant was introduced in 1964 for the management of endogenous depression. Much of the adverse effects are caused by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders and risk of suicide. The risk of suicide and dangers related to overdosage led the Norwegian Medicines Control Authority to put the higher strength formulation under prescribing restriction in 1992. The risk of death following overdosage is apparently higher for products containing tricyclic compounds as compared with nontricyclic products.
Biological Activity
Highly potent H 1 histamine receptor antagonist (K d = 310 pM) and tricyclic antidepressant. Also binds to the H 4 histamine receptor (pK i = 6.79).
Contact allergens
This benzoxepin tricylcic drug has antidepressant, anticholinergic, antiitching, and antihistamine properties. After oral use, it has been developed as a topical antiitching agent. Allergic contact dermatitis is not infrequent.
DOXEPIN Preparation Products And Raw materials
Raw materials
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| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | China | 12584 | 58 | Inquiry |
| Pushan Industry (Shaanxi) Co., Ltd | 029-81310890 18165209495 | China | 9997 | 58 | Inquiry |