ドキセピン 化学特性,用途語,生産方法
効能
抗うつ薬, ヒスタミン受容体拮抗薬, セロトニン・ノルアドレナリン再取り込み阻害薬
使用
Used clinically to treat anxiety and depression. Antidepressant
定義
ChEBI: A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
世界保健機関（WHO）
Doxepin, a tricyclic antidepressant was introduced in 1964 for the
management of endogenous depression. Much of the adverse effects are caused
by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias,
central nervous system disturbances, blood disorders and risk of suicide. The risk
of suicide and dangers related to overdosage led the Norwegian Medicines Control
Authority to put the higher strength formulation under prescribing restriction in
1992. The risk of death following overdosage is apparently higher for products
containing tricyclic compounds as compared with nontricyclic products.
生物活性
Highly potent H 1 histamine receptor antagonist (K d = 310 pM) and tricyclic antidepressant. Also binds to the H 4 histamine receptor (pK i = 6.79).
接触アレルゲン
This benzoxepin tricylcic drug has antidepressant, anticholinergic,
antiitching, and antihistamine properties.
After oral use, it has been developed as a topical antiitching
agent. Allergic contact dermatitis is not infrequent.
ドキセピン 上流と下流の製品情報
原材料
準備製品