5-Hydroxytryptophan
- CAS No.
- 56-69-9
- Chemical Name:
- 5-Hydroxytryptophan
- Synonyms
- HYDROXYTRYPTOPHAN;5-HYDROXY-DL-TRYPTOPHAN;2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID;DL-5-HTP;DL-5-HYDROXYTRYPTOPHAN;NSC-92523;USAF CB-96;nci-c56644;JACS-56-69-9;5-HTP AMino acid
- CBNumber:
- CB0110022
- Molecular Formula:
- C11H12N2O3
- Molecular Weight:
- 220.22
- MOL File:
- 56-69-9.mol
- Modify Date:
- 2024/6/27 18:15:55
| Melting point | 298-300°C |
|---|---|
| Boiling point | 361.16°C (rough estimate) |
| Density | 1.484 |
| refractive index | 1.5200 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | solid |
| pka | 2.22±0.10(Predicted) |
| color | Off-White to Pale Beige |
| Water Solubility | Soluble in water (4 mg/ml at 25°C), methanol. |
| Merck | 14,4847 |
| BRN | 88199 |
| InChIKey | LDCYZAJDBXYCGN-UHFFFAOYSA-N |
| LogP | -0.292 (est) |
| CAS DataBase Reference | 56-69-9(CAS DataBase Reference) |
| EPA Substance Registry System | Tryptophan, 5-hydroxy- (56-69-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YN7100000 | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
5-Hydroxytryptophan price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 797103 | 5-Hydroxy-DL-tryptophan | 56-69-9 | 5MG | ₹9645.08 | 2022-06-14 | Buy |
| ottokemi | H 1716 | 5-Hydroxy-DL-tryptophan 99% | 56-69-9 | 5mg | ₹9009 | 2022-05-26 | Buy |
| ottokemi | H 1716 | 5-Hydroxy-DL-tryptophan 99% | 56-69-9 | 10mg | ₹14031 | 2022-05-26 | Buy |
| ottokemi | H 1716 | 5-Hydroxy-DL-tryptophan 99% | 56-69-9 | 1gm | ₹35019 | 2022-05-26 | Buy |
5-Hydroxytryptophan Chemical Properties,Uses,Production
Description
5-Hydroxytryptophan (5-HTP) is an aromatic amino acid naturally produced by the body from the essential amino acid L-tryptophan (LT). Produced commercially by extraction from the seeds of the African plant, Griffonia simplicifolia, 5-HTP has been used clinically for over 30 years. The clinical efficacy of 5-HTP is due to its ability to increase production of serotonin in the brain.
Chemical Properties
Off-White to Pale Beige Solid, slightly salty in taste, soluble in methanol, ethanol, DMSO and other organic solvents, derived from African Ghana seeds.
Uses
5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. Clinical studies suggest that 5-HTP supports healthy serotonin levels. In the body, 5-HTP converts to serotonin with the enzymatic removal of a carboxyl group (COOH). Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep/wake cycles.
Application
5-hydroxytryptophan is a dietary supplement made from the seeds of the African plant Griffonia simplicifolia.
5-hydroxytryptophan has been used in alternative medicine as a possibly effective aid in treating depression or fibromyalgia.
Other uses not proven with research have included insomnia, alcohol withdrawal, headaches, premenstrual syndrome, binge-eating related to obesity, attention deficit disorder, and muscle spasms in the mouth.
5-hydroxytryptophan is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Definition
ChEBI: 5-hydroxytryptophan is a tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5. It has a role as a human metabolite and a neurotransmitter.
Preparation
The synthesis of 5-hydroxytryptophan (5-HTP) by the condensation of 5-benzyloxygramine with diethyl formaminomalonate, followed by saponification, decarboxylation, and hydrogenolysis was described in 1951 and 1954 and was an application of gramine synthesis, developed by Snyder and Smith ten years before. A few years later, another application of gramine synthesis was reported. In the same year, Frangatos and Chubb reported an application of the convenient tryptophan synthesis developed ten years before by eliminating the difficult and tedious preparation of 5-benzyloxyindole. The p-benzyloxyphenylhydrazone of γ,γ-dicarbethoxy-γ-acetamido-butyraldehyde (I) was prepared and cyclized, without isolation, to form ethyl β-(5-benzyloxyindol-3-)-αcarbethoxy-α-acetamidopropioilate (II). Saponification and partial decarboxylation of II, followed by hydrolysis of the acetamido group, gave 5-benzyloxytryptophan (III). 5-HTP was obtained by hydrogenolysis of III (Figure 1). However, this synthetic method suffers from the difficulty involved in the regioselective hydroxylation of tryptophan.
synthesis of 5-hydroxytryptophan (5-HTP)
Biosynthesis
5-Hydroxytryptophan, an intermediate molecule in the serotonin biosynthesis pathway, is formed by the addition of a hydroxyl (OH) group to the fifth carbon of the indole ring of tryptophan. It is used as an antiepileptic and antidepressant.
5-Hydroxytryptophan Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CR Chemical Resources | 07814122220 | Haryana, India | 6 | 58 | Inquiry |
| Alkaloids Pvt Ltd. | 08048361297Ext 958 | Kolkata, India | 6 | 58 | Inquiry |
| Chemical Technology | 09699402899 | Mumbai, India | 7 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12456 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| CR Chemical Resources | 58 |
| Alkaloids Pvt Ltd. | 58 |
| Chemical Technology | 58 |
| Pharma Affiliates | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Hebei Mojin Biotechnology Co., Ltd | 58 |
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