3-Indolepropionic acid
- CAS No.
- 830-96-6
- Chemical Name:
- 3-Indolepropionic acid
- Synonyms
- PROPAN-2-OL;INDOLE-3-PROPIONIC ACID;3-(1H-INDOL-3-YL)PROPANOIC ACID;ISOPROPANE;ISOPROPYL ALCOHO;ISOPROPANOL ALCOHOL;INDOLEPROPIONIC ACID;2-PPROPANOL;FEMA 2929;ISOPROPANO
- CBNumber:
- CB1183728
- Molecular Formula:
- C11H11NO2
- Molecular Weight:
- 189.21
- MOL File:
- 830-96-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/6 17:45:48
| Melting point | ~133 °C |
|---|---|
| Boiling point | 82 °C(lit.) |
| Density | 0.960 g/mL at 20 °C |
| vapor density | 2.1 (vs air) |
| vapor pressure | 33 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 53 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: soluble50mg/mL, clear, yellow to orange |
| pka | 4.77±0.10(Predicted) |
| form | crystalline |
| color | light yellow |
| Water Solubility | slightly soluble |
| BRN | 147733 |
| CAS DataBase Reference | 830-96-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Indole-3-propionic acid(830-96-6) |
| EPA Substance Registry System | 1H-Indole-3-propanoic acid (830-96-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NM1329000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339990 | |||||||||
| Toxicity | LDLo intraperitoneal in mouse: 100mg/kg | |||||||||
| NFPA 704 |
|
3-Indolepropionic acid price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 57410 | Indole-3-propionic acid ≥97.0% (T) | 830-96-6 | 100G | ₹5044.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 57410 | Indole-3-propionic acid ≥97.0% (T) | 830-96-6 | 25G | ₹8822.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 57400 | Indole-3-propionic acid ≥99.0% (T) | 830-96-6 | 5G | ₹5466.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 220027 | 3-Indolepropionic acid ReagentPlus?, 99% | 830-96-6 | 1G | ₹1851.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 220027 | 3-Indolepropionic acid ReagentPlus?, 99% | 830-96-6 | 10G | ₹3972.78 | 2022-06-14 | Buy |
3-Indolepropionic acid Chemical Properties,Uses,Production
Description
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.
Chemical Properties
pale yellow to yellow crystalline powder
Uses
3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.
Definition
ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.
General Description
3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.
Purification Methods
Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.]
3-Indolepropionic acid Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Soham Chemical Industries | +91-7016081644 +91-7016081644 | Mumbai, India | 83 | 58 | Inquiry |
| SHIVAM INDUSTRIES | +91-9820823043 +91-9820823043 | Mumbai, India | 30 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Nyne Organics Pvt Ltd | +91-9920180386 +91-9920180386 | Mumbai, India | 53 | 58 | Inquiry |
| DeFINE CHEMICALS | +91-8010769889 +91-9320057099 | Maharashtra, India | 120 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| K. Patel Chemopharma Private Limited | 91-22-48822900 | Maharashtra, India | 41 | 58 | Inquiry |
| Heni Chemical Industries | 08048372737Ext 240 | Mumbai, India | 27 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Soham Chemical Industries | 58 |
| SHIVAM INDUSTRIES | 58 |
| AARTIA KEM SCIENCE | 58 |
| Nyne Organics Pvt Ltd | 58 |
| DeFINE CHEMICALS | 58 |
| AKASH PHARMA EXPORTS | 58 |
| K. Patel Chemopharma Private Limited | 58 |
| Heni Chemical Industries | 58 |
| HiMedia Laboratories | 58 |
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