Doxepin hydrochloride
- CAS No.
- 1229-29-4
- Chemical Name:
- Doxepin hydrochloride
- Synonyms
- DOXEPIN HCL;Sinequan;p-4599;adapin;Toruan;Novoxapin;TIMTEC-BB SBB005916;Doxepin Hydrochlorid;Doxopin hydrochloride;DOXEPIN HYDROCHLORIDE
- CBNumber:
- CB0334620
- Molecular Formula:
- C19H22ClNO
- Molecular Weight:
- 315.84
- MOL File:
- 1229-29-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/21 14:17:16
| Melting point | 187-189°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | 1 M HCl: 50 mg/mL |
| form | powder |
| color | white to off-white |
| Water Solubility | Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO. |
| λmax | 298nm(lit.) |
| Merck | 14,3435 |
| Stability | Store in Freezer at -20°C |
| InChIKey | MHNSPTUQQIYJOT-SJDTYFKWSA-N |
| CAS DataBase Reference | 1229-29-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 25-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 36/37/39-45-36/37-16 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HQ4375000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29329990 | |||||||||
| Toxicity | LD50 oral in rat: 147mg/kg | |||||||||
| NFPA 704 |
|
Doxepin hydrochloride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D-927 | Doxepin hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 1229-29-4 | 1ML | ₹2407.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D4526 | Doxepin hydrochloride ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder | 1229-29-4 | 1G | ₹6873.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D4526 | Doxepin hydrochloride ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder | 1229-29-4 | 5G | ₹22635.08 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4626 | Doxepin Hydrochloride (mixture of isomers) | 1229-29-4 | 1G | ₹3400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4626 | Doxepin Hydrochloride (mixture of isomers) | 1229-29-4 | 5G | ₹9400 | 2022-05-26 | Buy |
Doxepin hydrochloride Chemical Properties,Uses,Production
Description
Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; Kds = 68 and 29.5 nM, respectively). It is a histamine H1 receptor antagonist (Ki = 1.23 nM). Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively). It also binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-adrenergic receptors (α1-ARs; Kds = 27, 23, and 23.5 nM, respectively). Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain. It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg. Formulations containing doxepin have been used in the treatment of depression and insomnia.
Chemical Properties
White Solid
Uses
Doxepin hydrochloride is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.It is a antidepressant used clinically to treat anxiety and depression.
Indications
Doxepin (Sinequan, Adapin) is a tricyclic antidepressant with potent H1 and H2 antagonistic effects. It also has antimuscarinic, antiserotonic, and anti-α-adrenergic activity. Use of 10 to 50 mg PO t.i.d. to q.i.d. has been shown to be effective in the treatment of primary acquired, chronic idiopathic urticaria, idiopathic cold urticaria, and for patients with anxiety or depression associated with their urticaria. Sedation and dry mouth are the most common side effects. Doxepin may interact with other drugs that are metabolized by the cytochrome P-450 system (ketoconazole, itraconazole, erythromycin, clarithromycin, etc.).
General Description
Doxepin, 3-dibenz[b,e]-oxepin-11(6H)ylidine-N,N-dimethyl-1-propanamine hydrochloride, N,N-dimethyl-3-(dibenz[b,e]oxepin-11(6H)-ylidene)propylamine (Sinequan, Adapin), isan oxa congener of amitriptyline, as can be seen from itsstructure.
The oxygen is interestingly placed and should influenceoxidative metabolism as well as postsynaptic and presynapticbinding affinities. The (Z)-isomer is the more active, althoughthe drug is marketed as the mixture of isomers. Thedrug overall is a NE and 5-HT reuptake blocker with significantanticholinergic and sedative properties. It can be anticipatedthat the nor- or des- metabolite will contribute to theoverall activity pattern.
Doxepin hydrochloride Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| R L Fine Chem Pvt. Ltd | +91-8042488999 +91-8042488999 | Karnataka, India | 74 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| R.L. Fine Chem | +91 80 28561041 | Karnataka, India | 10 | 58 | Inquiry |
| Raks Pharma Pvt Ltd | 08066085813Ext 651 | Andhra Pradesh, India | 19 | 58 | Inquiry |
| Metro Exporters Pvt. Ltd. | 91-22-24916500 | Maharashtra, India | 204 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Thykn (India) International | 91-22-67033666 | Maharashtra, India | 89 | 58 | Inquiry |
| Titan Pharma India Private Limited | -67856931 | Mumbai, India | 84 | 58 | Inquiry |
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