Dimethylamine
- CAS No.
- 124-40-3
- Chemical Name:
- Dimethylamine
- Synonyms
- (CH3)2NH;Dimethylamin;Metformin EP Impurity F;DiMethylaMine (~2.0 M in THF);Dimethylamine methanol solution;DiMethylaMine, 2.0 M solution in THF, SpcSeal;Dimethylamine (ca. 10% in Tetrahydrofuran, ca. 2mol/L);DMA-40;DMA-60;DMA-65
- CBNumber:
- CB8852986
- Molecular Formula:
- C2H7N
- Molecular Weight:
- 45.08
- MOL File:
- 124-40-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/29 14:28:21
| Melting point | −93 °C(lit.) |
|---|---|
| Boiling point | 7 °C(lit.) |
| Density | 0.89 g/mL at 25 °C |
| vapor density | 1.55 (vs air) |
| vapor pressure | 16.97 psi ( 55 °C) |
| refractive index |
n |
| Flash point | 60 °F |
| storage temp. | Flammables area |
| solubility | very soluble in water (163 g/100 g water at 40°C); soluble in ethanol, ethyl ether, and many organic solvents |
| form | Solution |
| pka | 10.68(at 25℃) |
| color | Clear slightly yellow |
| Odor | Ammonical odour |
| Odor Threshold | 0.033ppm |
| explosive limit | 14.4% |
| Water Solubility | Miscible with water and most organic solvents. |
| Sensitive | Hygroscopic |
| Merck | 14,3228 |
| BRN | 605257 |
| Henry's Law Constant | 1.75(x 10-5 atm?m3/mol) at 25 °C (Christie and Crisp, 1967) |
| Exposure limits | TLV-TWA 10 ppm (～18 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 2000 ppm (NIOSH). |
| Dielectric constant | 6.3（0℃） |
| Stability | Stable. Generally used as a solution in water at concentrations up to around 40%. Extremely flammable in the pure form. Incompatible with strong oxidizing agents. |
| LogP | -0.274 at 25℃ |
| CAS DataBase Reference | 124-40-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanamine, N-methyl-(124-40-3) |
| EPA Substance Registry System | Dimethylamine (124-40-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H314-H335-H412 | |||||||||
| Precautionary statements | P210-P233-P273-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | F+,Xn,C,F,T | |||||||||
| Risk Statements | 12-20-37/38-41-34-20/22-11-39/23/24/25-23/24/25-52/53-40-19 | |||||||||
| Safety Statements | 3-16-26-29-36/37/39-45-39-61 | |||||||||
| RIDADR | UN 2924 3/PG 2 | |||||||||
| OEB | A | |||||||||
| OEL | TWA: 10 ppm (18 mg/m3) | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | IP8750000 | |||||||||
| F | 3 | |||||||||
| Autoignition Temperature | 753 °F | |||||||||
| TSCA | Yes | |||||||||
| DOT Classification | 2.1 (Flammable gas) | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29211100 | |||||||||
| Toxicity | Acute oral LD50 for guinea pigs 340 mg/kg, mice 316 mg/kg, rats 698 mg/kg, rabbits 240 mg/kg (quoted, RTECS, 1985). | |||||||||
| IDLA | 500 ppm | |||||||||
| NFPA 704 |
|
Dimethylamine price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.22033 | Dimethylamine (40% aqueous solution) for synthesis | 124-40-3 | 2.5L | ₹5859.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.22033 | Dimethylamine (40% aqueous solution) for synthesis | 124-40-3 | 1L | ₹6120 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 426458 | Dimethylamine solution 40?wt. % in H2O | 124-40-3 | 100ML | ₹2987.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 426458 | Dimethylamine solution 40?wt. % in H2O | 124-40-3 | 1L | ₹4979.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 426458 | Dimethylamine solution 40?wt. % in H2O | 124-40-3 | 2L | ₹6267.68 | 2022-06-14 | Buy |
Dimethylamine Chemical Properties,Uses,Production
Description
Dimethylamine is a colourless flammable gas at room temperature. It has a pungent, fishy, or ammonia-like odour at room temperature and is shipped and marketed in compressed liquid form. It is very soluble in water and soluble in alcohol and ether. It is incompatible with oxidising materials, acrylaldehyde, fluorine, maleic anhydride, chlorine, or mercury. Dimethylamine is a precursor to several industrially important compounds. For instance, it used in the manufacture of several products, for example, for the vulcanisation process of rubber, as detergent soaps, in leather tanning, in the manufacture of pharmaceuticals, and also for cellulose acetate rayon treatment.
dimethylamine structure
Chemical Properties
Dimethylamine reacts readily with acids to produce salts due to the presence of the unshared electron pair on the nitrogen atom. Similarly, dimethylamine reacts with acid anhydrides, halides, and esters, with CO2 or CS2, or with isocyanic or isothiocyanic acid derivatives. It can also react with nitrite, especially under acidic conditions, and possibly nitrogen oxides (Iqbel 1986) to form N-nitrosodimethylamine, a potent carcinogen in various animal species and a suspect human carcinogen (ATSDR 1989; Scanlan 1983; Zeisel et al 1988). N-Nitrosodimethylamine also can be formed upon storage of aqueous dimethylamine solutions or formulations of the dimethylamine salts of the herbicides 2,4D and MCPA (Wigfield and McLenaghan 1987a,b). Dimethylamine also can be nitrosated photochemically in aqueous solutions containing nitrite with the reaction occurring most readily at alkaline pH (Ohta et al 1982).
Physical properties
Clear, colorless liquid or gas with a strong, ammonia-like odor. Odor threshold concentrations of 33 ppbv and 47 ppbv were experimentally determined by (Leonardos et al., 1969) and Nagata and Takeuchi (1990), respectively.
Uses
Dimethylamine is used in the manufactureof N-methylformamide, N-methylacetamide,and detergent soaps; in tanning; and as anaccelerator in vulcanizing rubber. It is commercially sold as a compressed liquid intubes or as a 33% aqueous solution..
Definition
ChEBI: A secondary aliphatic amine where both N-substituents are methyl.
Air & Water Reactions
Highly flammable. Water soluble.
Reactivity Profile
DIMETHYLAMINE is a base, neutralizing acids in exothermic reactions, and a reducing agent. Dimethylamine is temperature sensitive. Reacts vigorously with mercury and chlorine . Reacts violently with strong oxidizing agents and attacks copper and copper compounds [Handling Chemicals Safely, 1980 p. 123]. Reacts with hypochlorites to give N-chloroamines, some of which are explosives when isolated [Bretherick, 1979 p. 108].
Hazard
Dimethylamine is an irritant, with a TLV of 10 ppm in air. The four-digit UN identification number is 1032. The NFPA 704 designation is health 3, flammability 4, and reactivity 0. The primary uses are in electroplating and as gasoline stabilizers, pharmaceuticals, missile fuels, pesticides, and rocket propellants.
Health Hazard
Dimethylamine is a strong irritant to the eyes,skin, and mucous membranes. Spill of liquidinto the eyes can cause corneal damage andloss of vision. Skin contact with the liquidcan produce necrosis. At sublethal concentra tions, inhalation of dimethylamine producedrespiratory distress, bronchitis, pneumonitis,and pulmonary edema in test animals. Theacute oral toxicity was moderate, greater thanfor monomethylamine.
LC50 value, inhalation (rats): 4540 ppm/6 hLD50 value, oral (mice): 316 mg/kg
Buckley and coworkers (1985) have investigated the inhalation toxicity of dimethylamine in F-344 rats and B6C3F1 mice.Animals exposed to 175 ppm for 6 h/day,5 days/week for 12 months showed significant lesions in the nasal passages. Rats developed more extensive olfactory lesions thandid mice. The study indicated that olfactory sensory cells were highly sensitive todimethylamine. Even at a concentration of10 ppm, the current threshold limit value,the rodents developed minor lesions fromexposure.
Fire Hazard
FLAMMABLE. Flashback along vapor trail may occur. May explode if ignited in an enclosed area. Vapors are eye, skin and respiratory irritants.
Industrial uses
Dimethylamine is used as an accelerator in vulcanizing rubber, as an antiknock agent for fuels, in photography, as a plasticizer, ion exchange agent, as an acid gas absorbent, a flotation agent, a dehairing agent in the tanning of leather and in electroplating (HSDB 1989; Sax and Lewis 1987; Windholz et al 1983). Dimethylamine also serves as the base for a large number of commercial products including detergent soaps, dyes, pharmaceuticals, textile chemicals, surfactants and in the manufacture of unsymmetrical dimethylhydrazine (used in missile fuels), the solvent dimethylacetanilide and in the synthesis of dimethylformamide, one of the most commonly used organic solvents. Usage of dimethylamine in 1972 was estimated at 50% for production of dimethylformamide and dimethylacetamide (used as spinning solvents for acrylic fibers), 15% as an intermediate in the preparation of the surfactant laurel dimethylamine oxide, 15% as an intermediate for rubber chemicals (including thorium accelerators), and 20% for other applications including the production of unsymmetrical dimethylhydrazine in rocket fuels and the dimethylamine salt of 2,4-dichlorophenoxyacetic acid (HSDB 1989). U.S. production and sales of dimethylamine in 1985 was 65.9 million pounds.
Safety Profile
Poison by ingestion. Moderately toxic by inhalation and intravenous routes. Mutation data reported. An eye irritant. Corrosive to the eyes, skin, and mucous membranes. A flammable gas. When heated to decomposition it emits toxic fumes of Nx,. Incompatible with acrylddehyde, fluorine, and maleic anhydride
Carcinogenicity
In a 2 year inhalation study in male F344 rats exposed to
175 ppm, no evidence of carcinogenicity was observed, and
in addition, despite severe tissue destruction in the anterior
nose following a single 6 h exposure, the nasal lesions
exhibited very little evidence of progression, even at
2 years of exposure. The authors concluded that this
indicated possible regional susceptibility to DMA toxicity or
a degree of adaptation by the rat to continued DMA exposure.
A detailed evaluation of mucociliary apparatus function
and response to alterations of nasal structure was presented
by the authors.
storage
Dimethylamine should be stored in a cool, dry, well-ventilated area in tightly sealed containers that are labeled in accordance with OSHA’s Hazard Communication Standard [29 CFR 1910.1200]. Containers of dimethylamine should be protected from physical damage and ignition sources, and should be stored separately from oxidizing materials, acrylaldehyde, fl uorine, maleic anhydride, chlorine, and mercury. Outside or detached storage is preferred. If stored inside, a standard flammable liquids cabinet or room should be used. Ground and bond metal containers and equipment when transferring liquids. Empty containers of dimethylamine should be handled appropriately.
Purification Methods
Dry dimethylamine by passage through a KOH-filled tower, or by standing with sodium pellets at 0o during 18hours. [Beilstein 4 IV 128.]
Precautions
During handling of dimethylamine, workers should use proper fume hoods, personal protective clothing and equipment, avoid skin contact, and use gloves, sleeves, and encapsulating suits. Dimethylamine is extremely flammable and may be ignited by heat, sparks, or open flames. Liquid dimethylamine will attack some forms of plastic, rubber, and coatings and is flammable. The vapors of dimethylamine are an explosion and poison hazard. Containers of dimethylamine may explode in the heat of a fi re and require proper disposal. Workers should use dimethylamine with adequate ventilation and containers must be kept properly closed.
Dimethylamine Preparation Products And Raw materials
Raw materials
Preparation Products
1of8
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Almas Life Sciences | +919441456585 | Hyderabad, India | 54 | 58 | Inquiry |
| Nikava Pharmaceutical Industries | +91-9653317212 +91-9653317212 | Mumbai, India | 20 | 58 | Inquiry |
| REDDY N REDDY PHARMACEUTICALS | +91-9848096759 +91-9848096759 | Hyderabad, India | 1989 | 58 | Inquiry |
| oswal chemicals | +91-9173644055 +91-9173644055 | Gujarat, India | 66 | 58 | Inquiry |
| Aero Agro Chemicals Industries Ltd | +91-9830051722 +91-9830051722 | Kolkata, India | 19 | 58 | Inquiry |
| Azeocryst Organic Private Limited | +91-8879077780 +91-8879077780 | Maharashtra, India | 32 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Rashtriya Chemicals and Fertilizers Limited | +91-9969062114 +91-9139357099 | Maharashtra, India | 13 | 58 | Inquiry |
124-40-3(Dimethylamine)Related Search:
1of4
chevron_right