Diphenhydramine
- CAS No.
- 58-73-1
- Chemical Name:
- Diphenhydramine
- Synonyms
- Benadryl;Benzhydryl;Dimedrol;DIPHENHYDRAMINE BASE;Benzhydril;Etanautine;Benzhydramine;Difenidramina;DiMenhydraMine;2-(Diphenylmethoxy)-N,N-dimethylethylamine
- CBNumber:
- CB6196202
- Molecular Formula:
- C17H21NO
- Molecular Weight:
- 255.35
- MOL File:
- 58-73-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/3 17:07:09
| Melting point | 167-172°C |
|---|---|
| Boiling point | bp2.0 150-165° |
| Density | 0.9889 (rough estimate) |
| refractive index | 1.5450 to 1.5490 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | pKa 9.1 (Uncertain) |
| color | Oil |
| Merck | 14,3309 |
| BCS Class | 1 |
| CAS DataBase Reference | 58-73-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethylamine, 2-diphenylmethoxy-n,n-dimethyl-(58-73-1) |
| EPA Substance Registry System | Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl- (58-73-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H302 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 | |||||||||
| RTECS | KR6825000 | |||||||||
| HS Code | 2922.19.7000 | |||||||||
| Toxicity | LD50 oral in rat: 390mg/kg | |||||||||
| NFPA 704 |
|
Diphenhydramine price More Price(2)
Diphenhydramine Chemical Properties,Uses,Production
Description
Diphenhydramine is one of the main representatives of antihistamine drugs that block H1 receptors. Besides antihistamine activity, diphenhydramine exhibits a local anesthetic effect, relaxes smooth muscle, and has sedative and soporific action.
Uses
Diphenhydramine also reduces muscle rigidity and general stiffness, and has a relatively minor effect on tremors.
Trade name
Benadryl (Parke-Davis)
Contact allergens
This antihistaminic drug with sedative properties is mainly sold over the counter. It can be used both topically (treatment of pruritis) and orally for its antiallergic, antiemetic, sedative, and anticough properties. Allergic or photoallergic contact dermatitis and fixeddrug eruption seem to be rare.
Safety Profile
Deadly human poison by an unspecified route. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. Human systemic effects by ingestion: somnolence, alteration of operant conditioning, changes in psychophysiological tests. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also ETHERS.
Environmental Fate
Diphenhydramine is fairly stable in the environment
although it does undergo photodegradation. Conjugates of
diphenhydramine such as diphenhydramine-N-glucuronide
may be converted back to the parent compound, diphenhydramine,
through enzymatic cleavage during sewage treatment
process. Diphenhydramine is removed poorly through wastewater
treatment processes and is found in significant concentrations
in aquatic organisms downstream from such plants.
Diphenhydramine has significant risk for bioaccumulation,
particularly in water downstream from wastewater and sewage
treatment facilities.
Solubility in water
One gram of diphenhydramine is soluble in 1 mL of water, 2 mL of ethanol, 2 mL of chloroform, or 50 mL of acetone; the compound is very slightly soluble in benzene or ether.
Diphenhydramine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 141 | 58 | Inquiry |
| Envee Drugs Pvt Ltd | +91-02682559595 +91-8866665858 | Gujarat, India | 36 | 58 | Inquiry |
| Wanbury Limited | +91-2271963222 +91-2267942222 | Maharashtra, India | 17 | 58 | Inquiry |
| Pratap Organics Pvt Ltd | +91 9920018682 +91 9152015164 | Maharashtra, India | 122 | 58 | Inquiry |
| S S Pharmachem | +91-9324209894 +91-9702111022 | Maharashtra, India | 20 | 58 | Inquiry |
| Heer Pharma Pvt Ltd | +91-9820051881 +91-9820051881 | Maharashtra, India | 102 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Pratap Organics Pvt. Ltd. | +91 (22) 2767-0445 | New Delhi, India | 80 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Frolic Pharmachem | 58 |
| Humble Healthcare Limited | 58 |
| Envee Drugs Pvt Ltd | 58 |
| Wanbury Limited | 58 |
| Pratap Organics Pvt Ltd | 58 |
| S S Pharmachem | 58 |
| Heer Pharma Pvt Ltd | 58 |
| OCEAN TRADING CORPORATION | 58 |
| Pratap Organics Pvt. Ltd. | 50 |
| A.J Chemicals | 58 |
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