Benzhydrol
- CAS No.
- 91-01-0
- Chemical Name:
- Benzhydrol
- Synonyms
- DIPHENYLMETHANOL;benzydrol;Benzhydryl alcohol;BENZOHYDROL;DIPHENYLCARBINOL;ALPHA-PHENYLBENZENEMETHANOL;NSC 32150;BENZHYDROL;BNEZHYDROL;Benzhydrol >
- CBNumber:
- CB8417044
- Molecular Formula:
- C13H12O
- Molecular Weight:
- 184.24
- MOL File:
- 91-01-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/11 8:43:22
| Melting point | 65-67 °C (lit.) |
|---|---|
| Boiling point | 297-298 °C (lit.) |
| Density | 1.0120 (rough estimate) |
| vapor pressure | 0.000076 hPa (20 °C) |
| refractive index | 1.5727 (estimate) |
| Flash point | 160 °C |
| storage temp. | Store below +30°C. |
| solubility | 0.52g/l insoluble |
| form | Crystalline Solid |
| pka | 13.55±0.20(Predicted) |
| color | White to beige |
| Odor | at 100.00 %. weedy green rose |
| Odor Type | green |
| Water Solubility | Slightly soluble in water. |
| Merck | 14,1090 |
| BRN | 1424379 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids. |
| LogP | 2.670 |
| CAS DataBase Reference | 91-01-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenemethanol, «alpha»-phenyl-(91-01-0) |
| EPA Substance Registry System | Benzenemethanol, .alpha.-phenyl- (91-01-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H315-H319-H335-H320 | |||||||||
| Precautionary statements | P264-P305+P351+P338+P337+P313-P305+P351+P338-P261-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DC7452000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29062900 | |||||||||
| Toxicity | LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Benzhydrol price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B4856 | Diphenylmethanol 99% | 91-01-0 | 5G | ₹2013.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B4856 | Diphenylmethanol 99% | 91-01-0 | 100G | ₹2413.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2071 | Benzhydrol Pharmaceutical Secondary Standard; Certified Reference Material | 91-01-0 | 100MG | ₹43029.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B4856 | Diphenylmethanol 99% | 91-01-0 | 500G | ₹5401.68 | 2022-06-14 | Buy |
| ALFA India | ALF-A12884-30 | Benzhydrol, 99% | 91-01-0 | 250g | ₹2817 | 2022-05-26 | Buy |
Benzhydrol Chemical Properties,Uses,Production
Chemical Properties
off-white powder or White or colorless crystals. M.P. 69℃. B.p. 281℃. Practically insoluble in water, soluble in alcohol, miscible with oils. The crystals have a very faint musty-rosy odor, somewhat similar to that of Benzophenonc and Trichloromethyl phenyl carbinyl acetate.
Uses
- Benzhydrols are industrially important compounds. On oxidation Benzhydrols yields Benzophenone, which are useful synthones for fullerenes, bioactive oxygen heterocycles, dyes and medicines. Various Cr (VI) and other oxidizing agents are used for oxidizing benzhydrol.
- Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.
- Intermediate in the preparation of Modafinil (M482500).
Preparation
By reduction of Benzophenone, e.g. with zinc in aqueous alkali.
Reactions
Benzhydrol is oxidized to benzophenone, by sodium hypochlorite (commonly known as bleach) in the presence of a phase-transfer catalyst.
Synthesis: In a 20-mL green capped vial, place 1.5 mL of ethyl acetate, 100 mg (0.54 mmol) of benzhydrol and a few drops of methyltricaprylammonium chloride solution (Stark's catalyst or tricaprylmethylammonium chloride). Add a half-inch magnetic stirring bar, and stir until all reagents are dissolved. Cool the solution in an ice bath and add 2 mL of 5% NaOCl (aq) (bleach) dropwise using a 2.5- mL syringe. After the addition of the hypochlorite is complete, allow the reaction to stir for five minutes in the ice-water bath and then stir for a period of one hour at room temperature.
Reduction of benzophenone to benzhydrol.
4MPDC (4-Methyl pyridinium di chromate) is used as oxidizing agent to oxidize benzhydrol. PDC is a mild and selective oxidizing agent and is soluble in water and many organic solvents. Therefore, advantage over inorganic dichromate.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Purification Methods
Crystallise benzhydrol from hot H2O or pet ether (b 60-70o), pet ether containing a little *benzene, from CCl4, or EtOH (1mL/g). An additional purification step includes passage of a *benzene solution through an activated alumina column. It sublimes in a vacuum. Also recrystallise it three times from MeOH/H2O [Naguib J Am Chem Soc 108 128 1986]. [Beilstein 6 IV 4648.]
Benzhydrol Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| TRC FINE CHEMS | +91-7400278327 +91-8097105248 | Mumbai, India | 73 | 58 | Inquiry |
| SURYA LIFE SCIENCES LIMITED | +91-2646226290 +91-9428511112 | Gujarat, India | 62 | 58 | Inquiry |
| CLEANCHEM LABORATORIES LLP | +91-9951015911 +91-9951015911 | Mumbai, India | 281 | 58 | Inquiry |
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| SNA HEALTHCARE PVT LTD | +91-8652842416 +91-8652842416 | Mumbai, India | 88 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Horizon | +91-7517039862 +91-7517039862 | Maharashtra, India | 36 | 58 | Inquiry |
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANJI BIOSCIENCES | 58 |
| TRC FINE CHEMS | 58 |
| SURYA LIFE SCIENCES LIMITED | 58 |
| CLEANCHEM LABORATORIES LLP | 58 |
| PERFECT CHEMICAL | 58 |
| GLP Pharma Standards | 58 |
| SNA HEALTHCARE PVT LTD | 58 |
| JSK Chemicals | 58 |
| Horizon | 58 |
| CNS CHEMICALS | 58 |
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