Benzophenone
- CAS No.
- 119-61-9
- Chemical Name:
- Benzophenone
- Synonyms
- BPN;DIPHENYL KETONE;Benzophenon;DIPHENYLMETHANONE;Methanone, diphenyl-;Phenyl ketone;dipheny ketone;IHT-PI BP;Benzophenone 0;BENZOPHENONE FLAKE
- CBNumber:
- CB5744679
- Molecular Formula:
- C13H10O
- Molecular Weight:
- 182.22
- MOL File:
- 119-61-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/12 15:32:57
| Melting point | 47-51 °C (lit.) |
|---|---|
| Boiling point | 305 °C (lit.) |
| Density | 1.11 |
| vapor density | 4.21 (vs air) |
| vapor pressure | 1 mm Hg ( 108 °C) |
| FEMA | 2134 | BENZOPHENONE |
| refractive index | 1.5893 |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | ethanol: soluble100mg/mL, clear, colorless (80% ethanol) |
| form | Crystalline Powder or Flakes |
| color | White to off-white |
| Odor | Characteristic. |
| Odor Type | balsamic |
| Water Solubility | insoluble (<0.1 g/100 mL at 25 ºC) |
| JECFA Number | 831 |
| Merck | 14,1098 |
| BRN | 1238185 |
| Dielectric constant | 13.0（20℃） |
| Stability | Stable. Incompatible with strong oxidizing agents, strong reducing agents. Combustible. |
| InChIKey | RWCCWEUUXYIKHB-UHFFFAOYSA-N |
| LogP | 3.18 at 25℃ |
| CAS DataBase Reference | 119-61-9(CAS DataBase Reference) |
| IARC | 2B (Vol. 101) 2013 |
| NIST Chemistry Reference | Benzophenone(119-61-9) |
| EPA Substance Registry System | Benzophenone (119-61-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H373-H412 | |||||||||
| Precautionary statements | P260-P273-P314-P501 | |||||||||
| Hazard Codes | Xi,N,Xn,F | |||||||||
| Risk Statements | 36/37/38-52/53-50/53-67-65-62-51/53-48/20-11-40 | |||||||||
| Safety Statements | 26-61-37/39-29-60-36-62-36/37-33-16-9 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DI9950000 | |||||||||
| F | 10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29143900 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit 3535 mg/kg | |||||||||
| NFPA 704 |
|
Benzophenone price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W213403 | Benzophenone FCC, FG | 119-61-9 | 1SAMPLE-K | ₹4990.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9300 | Benzophenone ReagentPlus?, 99% | 119-61-9 | 25G | ₹1970.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W213403 | Benzophenone FCC, FG | 119-61-9 | 1KG | ₹7361 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9300 | Benzophenone ReagentPlus?, 99% | 119-61-9 | 500G | ₹2413.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9300 | Benzophenone ReagentPlus?, 99% | 119-61-9 | 1KG | ₹3215.03 | 2022-06-14 | Buy |
Benzophenone Chemical Properties,Uses,Production
Chemical Properties
Benzophenone is a combustible, white, crystalline solid with a rose-like odor. soluble in ethanol, ether, chloroform and other organic solvents and monomers, insoluble in water. It is a free radical photoinitiator, mainly used in free radical UV curing systems, such as coatings, inks, adhesives, etc. It can be prepared in several ways, for example, by Friedel–Crafts reaction of benzene and benzoyl chloride with aluminum chloride, or of benzene and carbon tetrachloride, and oxidation of diphenylmethane.
Occurrence
Benzophenone has been found in various fruits, including Vitis vinifera L., black tea, cherimoya (Annona cherimola), mountain papaya (Carica pubescens), and soursop (Annona muricata L.).
Uses
Benzophenone is used as a synthetic intermediate for manufacture of pharmaceuticals and agricultural chemicals. It is also used as a photoinitiator in UV-curable printing inks, as a fragrance in perfumes, as a flavor enhancer in foods. Benzophenone can be added as a UV-absorbing agent to plastics, lacquers, and coatings at concentrations of 2–8%.
Production Methods
Benzophenone is commercially synthesized by the atmospheric oxidation of diphenylmethane using a catalyst of copper naphthenate. Alternatively, it can be produced by a Friedel–Crafts acylation of benzene using either benzoyl chloride or phosgene in the presence of aluminum chloride .
Definition
ChEBI: Benzophenone is the simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups. It has a role as a photosensitizing agent and a plant metabolite.
General Description
Benzophenone(119-61-9) appears as white solid with a flowery odor. May float or sink in water. It is a widely used building block in organic chemistry, being the parent diarylketone.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Ketones, such as Benzophenone, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. Benzophenone can react with oxidizing materials.
Health Hazard
Ingestion causes gastrointestinal disturbances. Contact causes eye irritation and, if prolonged, irritation of skin.
Fire Hazard
Flash point data for Benzophenone are not available, but Benzophenone is probably combustible.
Contact allergens
Unsubstituted benzophenone is largely used in chemical applications. It acts as a marker for photoallergy to ketoprofen.
Safety Profile
Moderately toxic by ingestion andintraperitoneal routes. Combustible when heated.Incompatible with oxidizers. When heated todecomposition it emits acrid and irritating fumes.
Potential Exposure
Benzophenone is used in UV curing of inks and coatings; as an intermediate; as an odor fixative in fragrances, flavoring, soaps; in the manufacture of pharmaceuticals and insecticides; in organic syntheses.
Carcinogenicity
Lifetime dermal carcinogenicity studies in mice and rabbits did not show any tumor excess in the treated animals. Female Swiss mice and New Zealand White rabbits of both sexes were treated dermally with 0, 5, 25, or 50% of benzophenone (0.02 mL) twice a week for 120 or 180 weeks. Weekly examination of the rabbits did not reveal any reduction in survival or appearance of tumors. Mice treated with benzophenone did not show any excess in the number of tumor-bearing animals or in total number of tumors compared to untreated control animals. Although three skin tumors were observed in the benzophenone- treated mice (one case of squamous cell carcinoma and two cases of squamous cell papilloma), there were also three tumors (one carcinoma and toe papillomas) observed in the control animals.
Metabolism
Benzophenone's main metabolic pathway in the rabbit is by reduction to benzhydrol, which is excreted conjugated with glucuronic acid(Williams, 1959).
Solubility in organics
Insoluble in water and glycerin, slightly soluble in Propylene glycol, 6% soluble in alcohol, soluble inmost perfume oils.
Shipping
UN1224 Ketones, liquid, n.o.s., Hazard Class: 3; Labels: 3—Flammable liquid, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9—Miscellaneous hazardous material, Technical Name Required.
Purification Methods
Crystallise it from MeOH, EtOH, cyclohexane, *benzene or pet ether, then dry in a current of warm air and store it over BaO or P2O5. It is also purified by zone melting and by sublimation [Itoh J Phys Chem 89 3949 1985, Naguib et al. J Am Chem Soc 108 128 1986, Gorman & Rodgers J Am Chem Soc 108 5074 1986, Ohamoto & Teranishi J Am Chem Soc 108 6378 1986, Naguib et al. J Phys Chem 91 3033 1987]. [Beilstein 7 III 2048, 7 IV 1357.]
Incompatibilities
Oxidizing materials, such as dichromates and permanganates.
Benzophenone Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
1of6
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| sheetalchemicals | +91-9820130159 +91-9820130159 | Maharashtra, India | 77 | 58 | Inquiry |
| Rsum Industries Pvt. Ltd. | +91-91062685255 +91-91062685255 | New Delhi, India | 29 | 58 | Inquiry |
| SYNOVA CHEMICALS | +91-9920741772 +91-9920741772 | Mumbai, India | 428 | 58 | Inquiry |
| Allchem Lifescience Pvt. Ltd | +919867655500 | Gujarat, India | 971 | 58 | Inquiry |
| Cyclo Pharma Chem | +91-9879685500 +91-9879685500 | Gujarat, India | 9 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Clarion Drugs Ltd | +91-7122552671 +91-7122552671 | Maharashtra, India | 49 | 58 | Inquiry |
| Chemikos Laboratories Pvt Ltd | +91-9849431423 +91-9849431423 | Telangana, India | 60 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| sheetalchemicals | 58 |
| Rsum Industries Pvt. Ltd. | 58 |
| SYNOVA CHEMICALS | 58 |
| Allchem Lifescience Pvt. Ltd | 58 |
| Cyclo Pharma Chem | 58 |
| JSK Chemicals | 58 |
| Clarion Drugs Ltd | 58 |
| Chemikos Laboratories Pvt Ltd | 58 |
Related articles
- The safety of Benzophenone
- The liver is the primary target organ of benzophenone toxicity in rats.
- Mar 14，2024
- Is Benzophenone polar or non-polar?
- Benzophenone is frequently used in the chemical industry as a flavoring agent, a fragrance enhancer, a UV-light protectant in ....
- Dec 21，2023
- A cosmetic additive-Benzophenone
- Benzophenone (BP) is an ultraviolet filter (UVF) widely used in personal care products such as sunscreens and cosmetics.
- Dec 7，2023
119-61-9(Benzophenone)Related Search:
1of4
chevron_right