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Toremifene

Toremifene Structure
CAS No.
89778-26-7
Chemical Name:
Toremifene
Synonyms
Toremifene USP/EP/BP;(2-[4-((Z)-4-CHLORO-1,2-DIPHENYL-BUT-1-ENYL)-PHENOXY]-ETHYL)-DIMETHYL-AMINE;C08166;101083;TOREMIFENE;Z-ToreMifene;Toremifene-d6;ChlortaMoxifen;2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]-n,n-dimethyl-ethanamine;2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-2-(4-(4-chloro-(z)-ethanamin
CBNumber:
CB0287854
Molecular Formula:
C26H28ClNO
Molecular Weight:
405.96
MOL File:
89778-26-7.mol
Modify Date:
2024/7/2 8:54:57

Toremifene Properties

Melting point 108-110°C
Boiling point 535.1±50.0 °C(Predicted)
Density 1.104±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility 25℃: DMSO 120mg/mL ;Water <1mg/mL; Ethanol <1mg/mL
pka 8.69±0.28(Predicted)
form Powder
color White to light yellow
Stability Light sensitive
CAS DataBase Reference 89778-26-7(CAS DataBase Reference)
IARC 3 (Vol. 66) 1996

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H318-H400-H410
Precautionary statements  P264-P280i-P301+P312a-P305+P351+P338-P310a-P501a
HazardClass  9

Toremifene Chemical Properties,Uses,Production

Description

Toremifene is an antiestrogenic anticancer agent effective in the treatment of advanced recurrent breast cancer in postmenopausal patients. It is claimed to be more effective than tamoxifen in several rat mammary tumor models. Side-effects are mild, including hot flushes and sweating.

Chemical Properties

White-to-Off-White Solid

Uses

An antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to tamoxifen

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TOREMIFENE 2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]-n,n-dimethyl-ethanamine (z)-2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine 2-(para-((z)-4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylamine 2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-2-(4-(4-chloro-(z)-ethanamin (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxyl]-N,N-dimethylethylamine C08166 ChlortaMoxifen Z-ToreMifene 2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)-N,N-dimethylethanamine Ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl- Toremifene-d6 101083 (Z)-2-(4-(4-chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)-N,N-dimethylethanamine (2-[4-((Z)-4-CHLORO-1,2-DIPHENYL-BUT-1-ENYL)-PHENOXY]-ETHYL)-DIMETHYL-AMINE Toremifene USP/EP/BP 89778-26-7 Anti-cancer & immunity Inhibitors Intermediates & Fine Chemicals Pharmaceuticals