ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Aromatic ketones >4-Hydroxybenzophenone
4-Hydroxybenzophenone
- CAS No.
- 1137-42-4
- Chemical Name:
- 4-Hydroxybenzophenone
- Synonyms
- POB;P-HYDROXYBENZOPHENONE;4-Hydroxydiphenylketone;NSC 1887;ENCL-001;benzoylphenol;Ospemifene INT;4-BENZOYLPHENOL;P-BENZOYLPHENOL;PARA-BENZOYLPHENOL
- CBNumber:
- CB9237221
- Molecular Formula:
- C13H10O2
- Molecular Weight:
- 198.22
- MOL File:
- 1137-42-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 132-135 °C(lit.) |
|---|---|
| Boiling point | 260-262°C 42mm |
| Density | 1.1184 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5954 (estimate) |
| Flash point | 260-262°C/24mm |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 8.14±0.13(Predicted) |
| form | Powder |
| color | White to beige to brown |
| Water Solubility | Insoluble in water. |
| BRN | 777776 |
| LogP | 1.6 at 35℃ |
| CAS DataBase Reference | 1137-42-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4) |
| EPA Substance Registry System | Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H373-H412 | |||||||||
| Precautionary statements | P260-P273-P314-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37-24/25-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | PC4959775 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145000 | |||||||||
| NFPA 704 |
|
4-Hydroxybenzophenone price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H20202 | 4-Hydroxybenzophenone 98% | 1137-42-4 | 25G | ₹6181.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H20202 | 4-Hydroxybenzophenone 98% | 1137-42-4 | 100G | ₹14667.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20661 | 4-Hydroxybenzophenone for synthesis | 1137-42-4 | 25G | ₹3090 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20661 | 4-Hydroxybenzophenone for synthesis | 1137-42-4 | 100G | ₹7560 | 2022-06-14 | Buy |
| ALFA India | ALF-A15096-30 | 4-Hydroxybenzophenone, 98% | 1137-42-4 | 250g | ₹13284 | 2022-05-26 | Buy |
4-Hydroxybenzophenone Chemical Properties,Uses,Production
Chemical Properties
white to beige fine crystalline powder
Uses
4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.
Preparation
Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.
Purification Methods
Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]
4-Hydroxybenzophenone Preparation Products And Raw materials
Raw materials
Aluminum chloride
Phenyl benzoate
Imidodicarbonic acid, 2-benzoyl-, 1,3-bis(1,1-dimethylethyl) ester
4-BENZYLOXYBENZOPHENONE
4-Methoxybenzophenone
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Global( 582)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Danopharm Chemicals Pvt.Ltd. | +91 9821080785 | Mumbai, India | 37 | 58 | Inquiry |
| NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
| SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
| BENZO CHEM INDUSTRIES PVT LTD | +91-2243555888 +91-2243555888 | Mumbai, India | 68 | 58 | Inquiry |
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Pratap Organics Pvt Ltd | +91 9920018682 +91 9152015164 | Maharashtra, India | 122 | 58 | Inquiry |
| Urmila Chemopharma | +91-9819537618 +91-8928751722 | Maharashtra, India | 25 | 58 | Inquiry |
| BASR Fine Chemicals Pvt. Ltd. | +91-9848230391 +91-9848230391 | Telangana, India | 908 | 58 | Inquiry |
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bc0001
1137-42-4