ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Aromatic ketones >4-Hydroxybenzophenone
4-Hydroxybenzophenone
![4-Hydroxybenzophenone Structure](CAS/GIF/1137-42-4.gif)
- CAS No.
- 1137-42-4
- Chemical Name:
- 4-Hydroxybenzophenone
- Synonyms
- POB;P-HYDROXYBENZOPHENONE;4-Hydroxydiphenylketone;NSC 1887;ENCL-001;benzoylphenol;Ospemifene INT;4-BENZOYLPHENOL;P-BENZOYLPHENOL;PARA-BENZOYLPHENOL
- CBNumber:
- CB9237221
- Molecular Formula:
- C13H10O2
- Molecular Weight:
- 198.22
- MOL File:
- 1137-42-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
Melting point | 132-135 °C(lit.) |
---|---|
Boiling point | 260-262°C 42mm |
Density | 1.1184 (rough estimate) |
vapor pressure | 0Pa at 20℃ |
refractive index | 1.5954 (estimate) |
Flash point | 260-262°C/24mm |
storage temp. | Store below +30°C. |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | 8.14±0.13(Predicted) |
form | Powder |
color | White to beige to brown |
Water Solubility | Insoluble in water. |
BRN | 777776 |
LogP | 1.6 at 35℃ |
CAS DataBase Reference | 1137-42-4(CAS DataBase Reference) |
NIST Chemistry Reference | Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4) |
EPA Substance Registry System | Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS08 |
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Signal word | Warning | |||||||||
Hazard statements | H373-H412 | |||||||||
Precautionary statements | P260-P273-P314-P501 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37-24/25-36 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | PC4959775 | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29145000 | |||||||||
NFPA 704 |
|
4-Hydroxybenzophenone price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | H20202 | 4-Hydroxybenzophenone 98% | 1137-42-4 | 25G | ₹6181.08 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | H20202 | 4-Hydroxybenzophenone 98% | 1137-42-4 | 100G | ₹14667.88 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.20661 | 4-Hydroxybenzophenone for synthesis | 1137-42-4 | 25G | ₹3090 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 8.20661 | 4-Hydroxybenzophenone for synthesis | 1137-42-4 | 100G | ₹7560 | 2022-06-14 | Buy |
ALFA India | ALF-A15096-30 | 4-Hydroxybenzophenone, 98% | 1137-42-4 | 250g | ₹13284 | 2022-05-26 | Buy |
4-Hydroxybenzophenone Chemical Properties,Uses,Production
Chemical Properties
white to beige fine crystalline powder
Uses
4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.
Preparation
Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.
Purification Methods
Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]
4-Hydroxybenzophenone Preparation Products And Raw materials
Raw materials
Aluminum chloride
Phenyl benzoate
Imidodicarbonic acid, 2-benzoyl-, 1,3-bis(1,1-dimethylethyl) ester
4-BENZYLOXYBENZOPHENONE
4-Methoxybenzophenone
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Global( 582)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
Danopharm Chemicals Pvt.Ltd. | +91 9821080785 | Mumbai, India | 37 | 58 | Inquiry |
NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
BENZO CHEM INDUSTRIES PVT LTD | +91-2243555888 +91-2243555888 | Mumbai, India | 68 | 58 | Inquiry |
PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
Pratap Organics Pvt Ltd | +91 9920018682 +91 9152015164 | Maharashtra, India | 122 | 58 | Inquiry |
Urmila Chemopharma | +91-9819537618 +91-8928751722 | Maharashtra, India | 25 | 58 | Inquiry |
BASR Fine Chemicals Pvt. Ltd. | +91-9848230391 +91-9848230391 | Telangana, India | 908 | 58 | Inquiry |
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POB
P-HYDROXYBENZOPHENONE
Ospemifene INT
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C7 to C8
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FINE Chemical & INTERMEDIATES
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Metabolites & Impurities
bc0001
1137-42-4