2,4-Dihydroxybenzophenone
- CAS No.
- 131-56-6
- Chemical Name:
- 2,4-Dihydroxybenzophenone
- Synonyms
- BP-1;UV-0;BENZOPHENONE-1;Uv 12;BENZORESORCINOL;uv12;4-BENZORESORCINOL;hhb;uf1;Uf 1
- CBNumber:
- CB5475441
- Molecular Formula:
- C13H10O3
- Molecular Weight:
- 214.22
- MOL File:
- 131-56-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/21 19:06:49
| Melting point | 144.5-147 °C(lit.) |
|---|---|
| Boiling point | 194 °C (1 mmHg) |
| Density | 1,32 g/cm3 |
| bulk density | 750kg/m3 |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5090 (estimate) |
| Flash point | 125 °C |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly, Heated), Ethanol (Slightly, Heated) |
| pka | 7.72±0.35(Predicted) |
| form | Crystalline Powder |
| color | Yellow |
| PH | 5 (10g/l, H2O, 20℃)(slurry) |
| biological source | human |
| Water Solubility | insoluble |
| Merck | 14,1106 |
| BRN | 1311566 |
| InChIKey | ZXDDPOHVAMWLBH-UHFFFAOYSA-N |
| LogP | 2.964 at 25℃ |
| CAS DataBase Reference | 131-56-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanone, (2,4-dihydroxyphenyl)phenyl-(131-56-6) |
| EPA Substance Registry System | Methanone, (2,4-dihydroxyphenyl)phenyl- (131-56-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H361fd-H411 | |||||||||
| Precautionary statements | P202-P264-P273-P280-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36-36/37/38-61 | |||||||||
| Safety Statements | 26-37/39-45-53 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DJ0700000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29145000 | |||||||||
| Hazardous Substances Data | 131-56-6(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg | |||||||||
| NFPA 704 |
|
2,4-Dihydroxybenzophenone price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SRP5162 | 4EBP1, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 185703-54-2 | 50μG | ₹36502.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.18652 | 2,4-Dihydroxybenzophenone for synthesis | 131-56-6 | 250G | ₹8060 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 126217 | 2,4-Dihydroxybenzophenone 99% | 131-56-6 | 100G | ₹3279.98 | 2022-06-14 | Buy |
| ALFA India | ALF-A13749-36 | 2,4-Dihydroxybenzophenone, 99% | 131-56-6 | 500g | ₹6879 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D0573 | 2,4-Dihydroxybenzophenone min. 98.0 % | 131-56-6 | 25G | ₹1800 | 2022-05-26 | Buy |
2,4-Dihydroxybenzophenone Chemical Properties,Uses,Production
Description
2,4-Dihydroxybenzophenone (DHP) is an organic compound derived from Garcinia xanthochymus, but there have been no reports on its biochemical functions and bioavailability. 2,4-dihydroxybenzophenone has been prepared by reacting resorcinol with benzoyl chloride or benzoic acid under anhydrous conditions in the presence of Friedel-Crafts catalysts such as AlCl3 or ZnCl2[1].
Chemical Properties
yellow crystalline powder
Uses
2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.
Preparation
Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).
Biological Activity
2,4-Dihydroxybenzophenone has potential effects on the stimulation of osteoblast differentiation and mitigate PDS-induced osteoporosisthrough the activation of the β-catenin pathway. Moreover, 2,4-Dihydroxybenzophenone demonstrated a capacity to enhance the expression of crucial osteogenic markers, including RUNX2, OSX, and ALP[2].
Contact allergens
BZP-1 is used, for example, in paints, plastics, and nail varnishes.
Safety Profile
Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Toxicology
As a persistent and bioaccumulative compound, 2,4-Dihydroxybenzophenone (BP-1) exhibits estrogenic activity or anti-androgenic activity in vitro, which could pose potential risks to the ecological environment and human health. At present, there are a large amount of reports that concentrated on the biotoxicity of BP-1, mainly focusing on its endocrine disrupting effects and genetic toxicity. Endocrine-toxicological studies have shown that the toxicity of BP-1 is five times that of bisphenol A (BPA)[2].
Purification Methods
Recrystallise it from MeOH. [Beilstein 8 IV 2442.]
References
[1] Mengting Zou . “Effective degradation of 2,4-dihydroxybenzophenone by zero–valent iron powder (Fe0)-activated persulfate in aqueous solution: Kinetic study, product identification and theoretical calculations.” Science of the Total Environment 771 (2021): Article 144743.
[2] Mirissa Hewage Dumindu Kavinda and & Gi-Young Kim*. “2,4′-Dihydroxybenzophenone Exerts Bone Formation and Antiosteoporotic Activity by Stimulating the β-Catenin Signaling Pathway.” ACS Pharmacology and Translational Science 7 2 (2024): 395–405.
2,4-Dihydroxybenzophenone Preparation Products And Raw materials
Raw materials
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