Drometrizole
- CAS No.
- 2440-22-4
- Chemical Name:
- Drometrizole
- Synonyms
- UV-P;TINUVIN P;2-(2-HYDROXY-5-METHYLPHENYL)BENZOTRIAZOLE;2-(2H-BENZOTRIAZOL-2-YL)-P-CRESOL;UV-71;Benazol II;RIASORB UV-P;Absorber UV-P;UV ABSORBER UV-P;2-(2H-Benzotriazol-2-yl)-p-kresol
- CBNumber:
- CB6426334
- Molecular Formula:
- C13H11N3O
- Molecular Weight:
- 225.25
- MOL File:
- 2440-22-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/2 21:09:47
| Melting point | 125.5-129.5 °C(lit.) |
|---|---|
| Boiling point | bp10 225° |
| Density | 1.38 |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5600 (estimate) |
| Flash point | 54°C |
| storage temp. | 15-25°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.15±0.43(Predicted) |
| color | Off-White to Pale Yellow |
| Water Solubility | 173μg/L at 20℃ |
| Merck | 14,3447 |
| Stability | Hygroscopic |
| InChIKey | MCPKSFINULVDNX-UHFFFAOYSA-N |
| LogP | 4.2 at 25℃ |
| CAS DataBase Reference | 2440-22-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-(2440-22-4) |
| EPA Substance Registry System | 2-(2H-Benzotriazol-2-yl)-p-cresol (2440-22-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H410 | |||||||||
| Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-53-43 | |||||||||
| Safety Statements | 22-24/25-36/37 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | GO6860000 | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 oral in mouse: 6500mg/kg | |||||||||
| NFPA 704 |
|
Drometrizole price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | CRM96697 | 2-(2-Hydroxy-5-methylphenyl)benzotriazole certified reference material, TraceCERT? | 2440-22-4 | 100MG | ₹14310.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 533203 | 2-(2-Hydroxy-5-methylphenyl)benzotriazole 97% | 2440-22-4 | 25G | ₹7869.78 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H0560 | 2-(2-Hydroxy-5-methylphenyl)benzotriazole | 2440-22-4 | 25G | ₹5400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0560 | 2-(2-Hydroxy-5-methylphenyl)benzotriazole | 2440-22-4 | 500G | ₹10600 | 2022-05-26 | Buy |
Drometrizole Chemical Properties,Uses,Production
Chemical Properties
Light yellow powder
Uses
Drometrizole is an intermediate reactant in the synthesis of UV light absorbers for polyester fibers.
Application
Intermediate reactant in the synthesis of UV light absorbers for polyester fibers
Reactant for synthesis of:
Benzotriazole UV absorbers with a blocked hydroxy group for us in UV curable paint
Maleimide-bound benzotriazole monomer to use for emulsion polymerization
Used in:
Microstereophotolithography and shape memory alloy for fabrication of miniaturized actuators
PVS and wood / PVC composites as a stabilizer
Acrylonitrile-butadiene-styrene as a UV absorber.
Definition
Drometrizole is a member of triazoles.
Toxicity evaluation
The mutagenicity study of drometrizole was performed using Salmonella typhimurium strains TA1538 and TA98 with metabolic activation in the Ames’ test. Spot test (10 and 100 mg drometrizole/plate) and top agar method (50 and 100 mg drometrizole/plate) were conducted. The results showed that drometrizole was not mutagenic.Mice and rats were administered 5.0 or 10.0 g/kg of drometrizole in sunflower oil by stomach tube intubation. After body weight and behaviour were monitored for 3 weeks, acute toxicity of drometrizole was evaluated to be low. The oral lethal dose (LD50) of drometrizole in mice was reported to be 6.5 g/kg and > 5.0g/kg. Oral toxicity was evaluated in rats for nail care cosmetics containing 1%, 0.3% and 0.03% of drometrizole. The LD50 of products containing 1% of drometrizole was > 15.0 g/kg. The LD50 of products containing 0.3% and 0.03% drometrizole was > 5.0 g/kg. No acute toxicity was observed in these treatments.
Drometrizole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4535 | 58 | Inquiry |
| High Grade Industries Pvt Ltd | +91-02240775076 +91-02240775076 | Maharashtra, India | 10 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Agron India Limited | 08048372456Ext 350 | Gujarat, India | 4 | 58 | Inquiry |
| High Grade Industries (I) Pvt. Ltd | 91-022-40775076 | Maharashtra, India | 7 | 58 | Inquiry |
| Globela Pharma Private Limited | 08048372576Ext 968 | Gujarat, India | 5 | 58 | Inquiry |
| Flexilis Pvt.Ltd. | 91-22-61323400 | Maharashtra, India | 7 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
Related articles
- Uses and safety of Drometrizole
- Drometrizole is a benzotriazole derivative used as an ultraviolet (UV) light absorber and stabilizer in cosmetics.
- Jul 19，2022
Related Qustion
- Q:What is Drometrizole used in cosmetic
- A:In cosmetics, drometrizole is categorized as a sunscreen ingredient and used as a UV light absorber and stabilizer.
- Sep 25，2024
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