Cresol
- CAS No.
- 1319-77-3
- Chemical Name:
- Cresol
- Synonyms
- CRESYLIC ACID;TRICRESOL;Cresols;HYDROXYTOLUENE;Mixed cresol;MIXED CRESOLS;CRESOL MIXTURE OF ISOMERS, CRUDE;krezol;Cresol;cresoli
- CBNumber:
- CB5853043
- Molecular Formula:
- C7H8O
- Molecular Weight:
- 108.14
- MOL File:
- 1319-77-3.mol
- Modify Date:
- 2024/3/14 15:18:27
| Melting point | -1--2°C |
|---|---|
| Boiling point | 88-94°C |
| Density | 1.04 |
| refractive index | 1.5410 to 1.5440 |
| Flash point | 82°C |
| storage temp. | Store at R.T. |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Odor | Sweet, tarry. |
| Water Solubility | 1.932 g/100 mL |
| Merck | 14,2579 |
| Exposure limits | TLV-TWA (skin) for all isomers, 5 ppm (～22 mg/m3 ) (ACGIH, MSHA, and OSHA), 10-hour TWA 2.3 ppm (～10 mg/m3 ) (NIOSH), IDLH 250 ppm (NIOSH). |
| Dielectric constant | 9.0（Ambient） |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | QTWJRLJHJPIABL-UHFFFAOYSA-N |
| LogP | 1.950 |
| CAS DataBase Reference | 1319-77-3(CAS DataBase Reference) |
| EPA Substance Registry System | Cresol (1319-77-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311-H314-H341-H412 | |||||||||
| Precautionary statements | P202-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 20-24/25-34-52/53-68 | |||||||||
| Safety Statements | 26-36/37/39-45-61-24/25 | |||||||||
| RIDADR | UN 2076 6.1/PG 2 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 2.3 ppm; 10.0 mg/m3 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | GO5950000 | |||||||||
| F | 8-23 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29071219 | |||||||||
| NFPA 704 |
|
Cresol price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 03869 | Cresol mixture of isomers technical, crude, ~85% (sum of isomers, GC) | 1319-77-3 | 1L | ₹5178.6 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C0698 | Cresol (mixture of isomers) min. 99.0 %(Equivalent mixture of o, m, p) | 1319-77-3 | 25ML | ₹2100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0698 | Cresol (mixture of isomers) min. 99.0 %(Equivalent mixture of o, m, p) | 1319-77-3 | 500ML | ₹9500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0412 | Cresol | 1319-77-3 | 25G | ₹1800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0412 | Cresol | 1319-77-3 | 500G | ₹2600 | 2022-05-26 | Buy |
Cresol Chemical Properties,Uses,Production
Description
Professions that involve dealing with the combustion of coal or wood may be exposed to higher levels of cresols than the general population. Environmental tobacco smoke is also a source of cresol exposure. Average cresol concentration may vary between the brand and type of cigarette in a 45-cubic meter chamber after six cigarettes had been smoked (ranged from 0.17 to 3.9 mg m3), although low levels of cresol can be detected in certain foods and tap water, and these do not constitute major sources of exposure for most population. Detectable levels of cresols have been reported in several consumer products including tealeaves, tomatoes, and ketchup as well as butter, oil, and various cheeses. Exposure to children occurs by the same routes that affect adults. Children are likely to be exposed to cresols through inhalation of contaminated air from automobile exhaust, waste incineration, and secondhand smoke.
Chemical Properties
Cresol,a clear amber to red liquid, also known as cresylic acid, methylphenol, and tricresol,is a mixture of three isomers of cresol derived from coaltar and is used in making plastics, ore flotation, refining petroleum, and as a strong antiseptic. Orthocresol is a color less solid with a melting point of 30 °C(86 OF) that is soluble in alcohol,but only slightly soluble in water. It is used in making disinfectants and as a plasticizer. Metacresol is a colorless liquid used in the manufacture of photographic developers,printing inks, and paint removers.It is also used as a leather preservative.The least soluble isomer, paracresol, is a colorless solid and is used in the production of dyes and pharmaceuticals.
Uses
Cresol is used in disinfectants and fumigants,in the manufacture of synthetic resins, inphotographic developers and explosives.
Production Methods
Cresol may be obtained from coal tar or prepared synthetically by either sulfonation or oxidation of toluene.
Definition
A mixture of isomers obtained from coal tar or petroleum.
General Description
Colorless to yellow liquids with a tarry odor. Flash point 178°F. Insoluble in water. Density 8.7 lb / gal. Poisonous by ingestion and skin absorption and corrosive to skin.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Mixing CRESOL in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid, oleum, [NFPA 1991].
Hazard
Irritant, corrosive to skin and mucous membranes, absorbed via skin. Questionable carcinogen.
Health Hazard
The toxic actions of cresol are similar tothose of phenol. The para-isomer is somewhat more toxic than the other two isomers.The toxic symptoms are weakness, confu-sion, depression of the central nervous system, dyspnea, and respiratory failure. It isan irritant to the eyes and skin. Skin con-tact can cause burn and dermatitis. Chroniceffects are gastrointestinal disorders, nervousdisorders, tremor, confusion, skin eruptions,oliguria, jaundice, and liver damage. SkinLD50 values in rats for o-, m-, and p-phenolsare 620, 1100, and 750 mg/kg, respectively.
Dietz and Mulligan (1988a,b) have investigated the subchronic toxicity of meta- andpara-cresols in Sprague-Dawley rats after13 weeks of oral gavage. There was noadverse effects from a dose of 50 mg/kg/day.High dose levels of 150 mg/kg/day producedcentral nervous system depression and reduction of body weight gain. p-Cresol was foundto be hepatotoxic and nephrotoxic, inducinga mild anemic effect. The acute toxicity ofmethyl phenols did not show any relationshipto the number or position of methyl groupson the phenol nucleus. In an acute toxicitystudy on Daphnia magna, Devillers (1988)found cresols to be more toxic than phenol,xylenols, and trimethylphenols.
Fire Hazard
Combustible. POISONOUS GASES MAY BE PRODUCED IN FIRE. Flammable toxic vapors given off in a fire. Sealed closed containers can build up pressure if exposed to heat.
Chemical Reactivity
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Pharmaceutical Applications
Cresol is used at 0.15-0.3% concentration as an antimicrobial preservative in intramuscular, intradermal, and subcutaneous injectable pharmaceutical formulations. It is also used as a preservative in some topical formulations and as a disinfectant. Cresol is not suitable as a preservative for preparations that are to be freeze-dried.
Safety
Reports of adverse reactions to cresol are generally associated with the use of either the bulk material or cresol-based disinfectants, which may contain up to 50% cresol, rather than for its use as a preservative. However, a recent case of cutaneous hypersensitivity reaction to the m-cresol component of an insulin formulation detected via intradermal and patch testing has been reported.
Cresol is similar to phenol although it is less caustic and toxic. However, cresol is sufficiently caustic to be unsuitable for skin and wound disinfection. In studies in rabbits, cresol was found to be metabolized and excreted primarily as the glucuronide.
A patient has survived ingestion of 12g of cresol though with severe adverse effects.
LD50 (mouse, oral): 0.76g/kg
LD50 (rabbit, skin): 2g/kg
LD50 (rat, oral): 1.45g/kg
Potential Exposure
Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.
Environmental Fate
It acts by disruption of the cell membrane by denaturation of proteins and enzymes of the cell.
storage
Cresol and aqueous cresol solutions darken in color with age and on exposure to air and light. Cresol should be stored in a well-closed container, protected from light, in a cool, dry place.
Shipping
UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.
Incompatibilities
Cresol has been reported to be incompatible with chlorpromazine. Antimicrobial activity is reduced in the presence of nonionic surfactants.
Waste Disposal
Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IM, IV, intradermal, and SC injections). Included in parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Cresol Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SHAKAMBARI AROMATICS PRIVATE LIMITED | +91 9819024666 | Kolkata, India | 13 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3077 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Lab Line Enterprises | 08046051421 | Haryana, India | 11 | 58 | Inquiry |
| Peekay Agencies Private Limited | 08048971823 | Kolkata, India | 26 | 58 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Supplier | Advantage |
|---|---|
| SHAKAMBARI AROMATICS PRIVATE LIMITED | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Central Drug House(P) Ltd. | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
| Triveni chemicals | 58 |
| Lab Line Enterprises | 58 |
| Peekay Agencies Private Limited | 58 |
| Scientific OEM | 38 |
| ALPHA CHEMIKA | 43 |
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