p-Cymene
- CAS No.
- 99-87-6
- Chemical Name:
- p-Cymene
- Synonyms
- Cymene;Cymol;4-ISOPROPYLTOLUENE;PARA CYMENE;P-ISOPROPYLTOLUENE;1-METHYL-4-ISOPROPYLBENZENE;P-CYMOL;lsopropyltoluene;1-Methyl-4-(1-methylethyl)-benzene;4-CYMENE
- CBNumber:
- CB9262508
- Molecular Formula:
- C10H14
- Molecular Weight:
- 134.22
- MOL File:
- 99-87-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | -68 °C |
|---|---|
| Boiling point | 176-178 °C(lit.) |
| Density | 0.86 g/mL at 25 °C(lit.) |
| vapor density | 4.62 (vs air) |
| vapor pressure | 1.5 mm Hg ( 20 °C) |
| FEMA | 2356 | P-CYMENE |
| refractive index |
n |
| Flash point | 117 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear |
| Odor | Mild, pleasant; aromatic, solvent-type. |
| Odor Threshold | 0.057ppm |
| explosive limit | 5.6% |
| Odor Type | terpenic |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 14,2763 |
| JECFA Number | 1325 |
| BRN | 1903377 |
| Dielectric constant | 2.3（17℃） |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| InChIKey | HFPZCAJZSCWRBC-UHFFFAOYSA-N |
| LogP | 4.1-4.8 at 20℃ |
| CAS DataBase Reference | 99-87-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-methyl-4-(1-methylethyl)-(99-87-6) |
| EPA Substance Registry System | p-Cymene (99-87-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H304-H361f-H411 | |||||||||
| Precautionary statements | P201-P202-P210-P273-P301+P310-P331 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2046 3/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GZ5950000 | |||||||||
| Autoignition Temperature | 817 °F | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29029090 | |||||||||
| Toxicity | LD50 orally in rats: 4750 mg/kg (Jenner) | |||||||||
| NFPA 704 |
|
p-Cymene price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W235601 | p-Cymene ≥97%, FG | 99-87-6 | 1SAMPLE-K | ₹4880.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W235601 | p-Cymene ≥97%, FG | 99-87-6 | 1KG | ₹7315.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W235601 | p-Cymene ≥97%, FG | 99-87-6 | 20KG | ₹46247.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C121452 | p-Cymene 99% | 99-87-6 | 25ML | ₹2620.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C121452 | p-Cymene 99% | 99-87-6 | 1L | ₹3760.65 | 2022-06-14 | Buy |
p-Cymene Chemical Properties,Uses,Production
Chemical Properties
p-Cymene is a monoterpene that is found in a variety of plants, including C. sativa, and has diverse biological activities, including antimicrobial, anticancer, antioxidant, anti-inflammatory, antinociceptive, and anxiolytic properties.p-Cymene inhibits the growth of S. typhimurium, E. coli, L. monocytogenes, S. epidermidis, and S. aureus with MIC values ranging from 0.266 to 0.608% v/v.It decreases the invasive activity of HT-1080 human fibrosarcoma cells in vitro by 87% when used at a concentration of 600 μM.In mouse hippocampus, p-Cymene (50 mg/kg, i.p.) reduces lipid peroxidation and nitrite content by 65.5 and 71.2%, respectively, and increases superoxide dismutase (SOD) and catalase activities by 22.7 and 119.3%, respectively, compared to vehicle control animals.Formulations containing p-cymene have been used as flavoring agents.
Occurrence
Widespread in nature; reported in the oils of cypress, Artemisia cina Bg., Ceylon cinnamon, boldo leaf, cascarilla, Cuminum cyminum L. and lemon; in the oils for seeds of coriander and Cicuta virosa; in the ether-extracted oils of Monarda fisulosa and Monarda puncata; in the star anise and nutmeg essential oils. Note that p-cymene reported in essential oil may be formed from the conversion of a cyclic terpene; its presence is indicative of aging in lemon essential oil. Reported found in citrus juices and peel oils, guava, papaya, black currant, pineapple, blueberry, blackberry, carrot, tomato, celery seed, cumin seed, mace, ginger, coriander seed, anise, nutmeg, mace, parsley, cardamom, cinnamon root and bark, pepper, peppermint oil, spearmint oil, cassia leaf and Thymus vulgaris.
Uses
As a diluent for lacquers, varnishes, and dyes; in the production of resins; as a component of fragrances; also found as a byproduct in the manufacture of sulfite paper pulp
Preparation
Obtained chiefly from the wash water of sulfite paper.
Definition
ChEBI: A monoterpene that is toluene substituted by an isopropyl group at position 4.
General Description
Colorless liquid with a mild pleasant odor. Floats on water.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic hydrocarbons, such as CYMENE, and strong oxidizing agents. They can react exothermically with bases and with diazo compounds. Substitution at the benzene nucleus occurs by halogenation (acid catalyst), nitration, sulfonation, and the Friedel-Crafts reaction.
Health Hazard
Inhalation causes impairment of coordination, headache. Contact with liquid causes mild irritation of eyes and skin. Ingestion causes irritation of mouth and stomach.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Chemical Reactivity
Reactivity with Water: No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Safety Profile
Mildly toxic by ingestion. Humans sustain central nervous system effects at low doses. A skin irritant. Flammable liquid. Explosion Hazard: Slight in the form of vapor. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Metabolism
In this compound both an isopropyl and a methyl group occur together and the available evidence shows that only the methyl group is oxidized, cumic acid (pisopropylbenzoic acid) and its conjugate (cuminuric acid) being the main metabolites in dogs and in sheep (Williams, 1959). Following inhalation, only a small part is excreted unchanged, the remainder being oxidized to water-soluble metabolites. As early as 1873, Ziegler suggested that the readily oxidized propyl side-chain formed a -COO H group (Browning, 1965): The ultimate product in the case of dogs and sheep is cumic acid, which is probably excreted as a conjugate with glycine (Gerarde, 1960).
Purification Methods
Wash p-cymene with cold, conc H2SO4 until there is no further colour change, then repeatedly with H2O, 10% aqueous Na2CO3 and H2O again. Dry it over Na2SO4, CaCl2 or MgSO4, and distil it. Further purification steps include steam distillation from 3% NaOH, percolation through silica gel or activated alumina, and a preliminary reflux for several days over powdered sulfur. Store it over CaH2. [Beilstein 5 IV 1060.]
p-Cymene Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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| HJ AROCHEM | +91-8690768060 +91-9724420086 | Ahmedabad, India | 171 | 58 | Inquiry |
| Swati Menthol and Allied Chemicals Ltd | +91-9837848873 +91-9837848871 | Uttar Pradesh, India | 49 | 58 | Inquiry |
| Desicca Chemicals | +91-7777090620 +91-9821128366 | Maharashtra, India | 20 | 58 | Inquiry |
| VDH Organics Pvt Ltd | +91-9821490096 +91-9818427779 | Uttar Pradesh, India | 24 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| VDH Organics Private Limited | 08048968674 | Uttar Pradesh, India | 32 | 58 | Inquiry |
| Swati Menthol And Allied Chemicals Limited | 09837848871 | Uttar Pradesh, India | 15 | 58 | Inquiry |
| Natural Aroma Products Private Limited | 08048612429 | Delhi, India | 47 | 58 | Inquiry |
| Camphor & Allied Products Limited | 09458586796 | Uttar Pradesh, India | 6 | 58 | Inquiry |
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