Diisopropylamine
- CAS No.
- 108-18-9
- Chemical Name:
- Diisopropylamine
- Synonyms
- DIPA;N,N-Diisopropylamine;Diisopropylamin;Diisoproplamine;Pyridine, 2-methoxy-;(iso-C3H7)2NH;AURORA KA-7634;DIISOPROPYLAMINE;Isodipropylamine;Torsemide SM3-Z2
- CBNumber:
- CB5852738
- Molecular Formula:
- C6H15N
- Molecular Weight:
- 101.19
- MOL File:
- 108-18-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:27
| Melting point | -61 °C (lit.) |
|---|---|
| Boiling point | 84 °C (lit.) |
| Density | 0.722 g/mL at 25 °C (lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 50 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 1.4 °F |
| storage temp. | Store below +30°C. |
| solubility | 100 g/L (20°C) |
| pka | 11.05(at 25℃) |
| form | Liquid |
| color | Clear colorless |
| Odor | Amine. |
| PH | 11.8 (6g/l, H2O, 20℃) |
| explosive limit | 1.1-7.1%(V) |
| Water Solubility | 100 g/L (20 ºC) |
| Merck | 14,3196 |
| BRN | 605284 |
| Exposure limits | NIOSH REL: TWA 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 5 ppm; ACGIH TLV: TWA 5 ppm (adopted). |
| Dielectric constant | 3.04 |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents. May react violently with strong acids or oxidizers. Air sensitive. |
| InChIKey | UAOMVDZJSHZZME-UHFFFAOYSA-N |
| LogP | 0.4 at 20℃ |
| CAS DataBase Reference | 108-18-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Propanamine, N-(1-methylethyl)-(108-18-9) |
| EPA Substance Registry System | Diisopropylamine (108-18-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302-H314-H331-H335-H412 | |||||||||
| Precautionary statements | P210-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | F,C | |||||||||
| Risk Statements | 11-20/22-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| OEB | A | |||||||||
| OEL | TWA: 5 ppm (20 mg/m3) [skin] | |||||||||
| RIDADR | UN 1158 3/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | IM4025000 | |||||||||
| Autoignition Temperature | 599 °F | |||||||||
| Hazard Note | Highly Flammable/Corrosive/Harmful | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2921 19 99 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 orally in rats: 0.77 g/kg (Smyth) | |||||||||
| IDLA | 200 ppm | |||||||||
| NFPA 704 |
|
Diisopropylamine price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.03646 | Diisopropylamine for synthesis | 108-18-9 | 10ML | ₹1389.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03646 | Diisopropylamine for synthesis | 108-18-9 | 8036460521 | ₹1760 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03646 | Diisopropylamine for synthesis | 108-18-9 | 100ML | ₹3160 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03646 | Diisopropylamine for synthesis | 108-18-9 | 1L | ₹3690.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03646 | Diisopropylamine for synthesis | 108-18-9 | 8036462521 | ₹7229.99 | 2022-06-14 | Buy |
Diisopropylamine Chemical Properties,Uses,Production
Description
Diisopropylamine is a secondary amine and is a colorless liquid at room temperature with a fishy, ammonia-like odor. It is used as a chemical intermediate, and catalyst for the synthesis of pesticides and pharmaceuticals. Diisopropylamine is associated with tobacco either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Synonyms for diisopropylamine include DIPA, and N-(1-methylethyl)-2- propanamine.
Chemical Properties
Diisopropylamine is a flammable, strongly alkaline Colorless liquid. Diisopropylamine is soluble in water and alcohol. The odor threshold ranges from 0.017 to 4.2 ppm; the fishlike odor becomes irritating at 100 mg/m3.
Physical properties
Colorless liquid with an ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 50 μg/m3 (130 ppbv) and 190 μg/m3 (380 ppbv), respectively (Hellman and Small, 1974).
Application
Diisopropylamine is used as a solvent and in the chemical synthesis of dyes, pharmaceuticals, and other organic syntheses. It used to synthesize diisopropylamine methyl urea (DMU), N,N-diisopropyl quinoline-2-carboxamide, 3-N-sulfonylamidine coumarins and N-chloroamine, an intermediate to generate amides.
Preparation
Diisopropylamine is produced by the reaction of diisopropyl alcohol with ammonia. Diisopropylamine is also may be prepared by the reductive amination of acetone with ammonia using a modified copper oxide, generally copper chromite, as a catalyst:
NH3+2(CH3)2CO+2H2 → C6H15N+2H2O
General Description
Diisopropylamine appears as a clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Soluble in water. Sensitive to heat and air.
Reactivity Profile
Diisopropylamine can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
Permitted levels of diisopropylamine should not cause adverse health and welfare effects. Acute inhalation exposure to diisopropylamine can cause sore throat, cough, burning sensation and shortness of breath. Adverse effects occur mainly in the upper respiratory tract, although after chronic exposure. There is no definitive evidence that diisopropylamine causes cancer so a chronic cancer value was not developed. Diisopropylamine has not been classified as causing cancer by the International Agency for Research on Cancer, the United States Environmental Protection Agency, the American Conference of Industrial Hygienists, or the National Toxicology Program.
Chemical Reactivity
Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Industrial uses
Diisopropylamine is used as a catalyst and as a stabilizer for mesityl oxide (HSDB 1989). It is also used as an intermediate in the synthesis of dyes, pharmaceuticals and pesticides (e.g. Diallate, Fenamiphos and Triallate).
Safety Profile
Moderately toxic by ingestion and subcutaneous routes. Mildly toxic by inhalation. Mutation data reported. A skin and severe eye irritant. Inhalation of fumes can cause pulmonary edema. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam,foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx See also AMINES.
Environmental Fate
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Reacts with acids forming water-soluble salts.
Metabolism
Little, if any investigation of the metabolism of short-chain aliphatic amines has been reported and the best that can be done is to suggest some possible metabolic routes. For example the flavin monooxygenase system could produce the hydroxylamine through N-hydroxylation catalyzed by the flavin monooxygenase system (Ziegler 1988). N-hydroxylation can also be induced with the cytochrome P-450 system as can N-dealkylation reactions (Lindeke and Cho 1982). More definitive analysis must await experimental studies.
Purification Methods
Distil the amine from NaOH, or reflux it three minutes over Na wire or NaH, and distil it into a dry receiver under N2. [Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]
Diisopropylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TRUUCHEM TECHNOLOGIES PRIVATE LIMITED | +91-8619349510 +91-8619349510 | Bangalore, India | 82 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3077 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TRUUCHEM TECHNOLOGIES PRIVATE LIMITED | 58 |
| JSK Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Triveni chemicals | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
| Central Drug House(P) Ltd. | 58 |
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