N,N'-Diisopropylcarbodiimide
![N,N'-Diisopropylcarbodiimide Structure](CAS/GIF/693-13-0.gif)
- CAS No.
- 693-13-0
- Chemical Name:
- N,N'-Diisopropylcarbodiimide
- Synonyms
- DIC;Diisopropylcarbodiimide;DIPC;DIPCI;DIPCDI;N,N-DIISOPROPYLCARBODIIMIDE;PCI;DICI;1,3-DIISOPROPYLCARBODIIMIDE;Diisopropylcarbodiimide solution
- CBNumber:
- CB4301572
- Molecular Formula:
- C7H14N2
- Molecular Weight:
- 126.2
- MOL File:
- 693-13-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/17 21:30:02
Melting point | 210-2120C (dec) |
---|---|
Boiling point | 145-148 °C(lit.) |
Density | 0.815 g/mL at 20 °C(lit.) |
vapor pressure | 34.9hPa at 55.46℃ |
refractive index |
n |
Flash point | 93 °F |
storage temp. | Store below +30°C. |
solubility | Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran. |
form | Liquid |
color | Clear colorless to yellow |
Sensitive | Moisture Sensitive |
BRN | 878281 |
Stability | Volatile |
InChIKey | BDNKZNFMNDZQMI-UHFFFAOYSA-N |
LogP | 4.11 at 20℃ |
CAS DataBase Reference | 693-13-0(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Propanamine, N,N'-methanetetraylbis-(693-13-0) |
EPA Substance Registry System | 2-Propanamine, N,N'-methanetetraylbis- (693-13-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() ![]() GHS02,GHS05,GHS06,GHS08 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H226-H317-H318-H330-H334 | |||||||||
Precautionary statements | P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
Hazard Codes | T+,T,F,Xn | |||||||||
Risk Statements | 10-26-36/37/38-41-42/43-37/38 | |||||||||
Safety Statements | 26-36/37/39-45-38-28A-16-22 | |||||||||
RIDADR | UN 2929 6.1/PG 1 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | FF2175000 | |||||||||
F | 10-21 | |||||||||
Hazard Note | Flammable/Highly Toxic/ | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29252000 | |||||||||
NFPA 704 |
|
N,N'-Diisopropylcarbodiimide price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | D125407 | DIC 99% | 693-13-0 | 5G | ₹885.49 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | D125407 | DIC 99% | 693-13-0 | 25G | ₹3951.13 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | D125407 | DIC 99% | 693-13-0 | 100G | ₹22018.05 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | D125407 | DIC 99% | 693-13-0 | 500G | ₹60977.23 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 901609 | Diisopropylcarbodiimide solution 1?M in dichloromethane | 693-13-0 | 25ML | ₹11555.33 | 2022-06-14 | Buy |
N,N'-Diisopropylcarbodiimide Chemical Properties,Uses,Production
Description
Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.
Chemical Properties
N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.
Uses
N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. In addition to this, it is used in the synthesis of acid anhydride, aldehyde, ketone and isocyanate.
Definition
ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.
General Description
N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.
Contact allergens
It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.
Synthesis
Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.
N,N'-Diisopropylcarbodiimide Preparation Products And Raw materials
Raw materials
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BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
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ADVENT CHEMBIO PRIVATE LIMITED | +91-9821524116 +91-9821524116 | Mumbai, India | 353 | 58 | Inquiry |
NSJ Prayog Life Sciences Private Limited | +91-6281747900 +91-6281747900 | Hyderabad, India | 76 | 58 | Inquiry |
Radison Labs Private Limited | +91-7337551966 +91-7337551966 | Hyderabad, India | 58 | 58 | Inquiry |
Organo Fine Chemicals | +91 (22) 2201-6968 / 2206-7521 | New Delhi, India | 266 | 60 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
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