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ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Amide >N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide Structure
CAS No.
693-13-0
Chemical Name:
N,N'-Diisopropylcarbodiimide
Synonyms
DIC;Diisopropylcarbodiimide;DIPC;DIPCI;DIPCDI;N,N-DIISOPROPYLCARBODIIMIDE;PCI;DICI;1,3-DIISOPROPYLCARBODIIMIDE;Diisopropylcarbodiimide solution
CBNumber:
CB4301572
Molecular Formula:
C7H14N2
Molecular Weight:
126.2
MOL File:
693-13-0.mol
MSDS File:
SDS
Modify Date:
2024/8/17 21:30:02
Request For Quotation

N,N'-Diisopropylcarbodiimide Properties

Melting point 210-2120C (dec)
Boiling point 145-148 °C(lit.)
Density 0.815 g/mL at 20 °C(lit.)
vapor pressure 34.9hPa at 55.46℃
refractive index n20/D 1.433(lit.)
Flash point 93 °F
storage temp. Store below +30°C.
solubility Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
form Liquid
color Clear colorless to yellow
Sensitive Moisture Sensitive
BRN 878281
Stability Volatile
InChIKey BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP 4.11 at 20℃
CAS DataBase Reference 693-13-0(CAS DataBase Reference)
NIST Chemistry Reference 2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA Substance Registry System 2-Propanamine, N,N'-methanetetraylbis- (693-13-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H317-H318-H330-H334
Precautionary statements  P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T+,T,F,Xn
Risk Statements  10-26-36/37/38-41-42/43-37/38
Safety Statements  26-36/37/39-45-38-28A-16-22
RIDADR  UN 2929 6.1/PG 1
WGK Germany  3
RTECS  FF2175000
F  10-21
Hazard Note  Flammable/Highly Toxic/
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29252000
NFPA 704
2
4 1

N,N'-Diisopropylcarbodiimide price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D125407 DIC 99% 693-13-0 5G ₹885.49 2022-06-14 Buy
Sigma-Aldrich(India) D125407 DIC 99% 693-13-0 25G ₹3951.13 2022-06-14 Buy
Sigma-Aldrich(India) D125407 DIC 99% 693-13-0 100G ₹22018.05 2022-06-14 Buy
Sigma-Aldrich(India) D125407 DIC 99% 693-13-0 500G ₹60977.23 2022-06-14 Buy
Sigma-Aldrich(India) 901609 Diisopropylcarbodiimide solution 1?M in dichloromethane 693-13-0 25ML ₹11555.33 2022-06-14 Buy
Product number Packaging Price Buy
D125407 5G ₹885.49 Buy
D125407 25G ₹3951.13 Buy
D125407 100G ₹22018.05 Buy
D125407 500G ₹60977.23 Buy
901609 25ML ₹11555.33 Buy

N,N'-Diisopropylcarbodiimide Chemical Properties,Uses,Production

Description

Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.

Chemical Properties

N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.

Uses

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. In addition to this, it is used in the synthesis of acid anhydride, aldehyde, ketone and isocyanate.

Definition

ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.

General Description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Contact allergens

It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.

Synthesis

Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.
N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide Preparation Products And Raw materials

Raw materials

MOLECULAR SIEVES PACK 4A 1,2-DIETHOXYDISULFANE LEAD CARBONATE Benzene Dichloromethane
N,N'-DIISOPROPYLTHIOUREA
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Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE
4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE 2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA 4,5-Imidazolidinedione, 2,2-dichloro-1,3-bis(1-methylethyl)- BIS(N N'-DIISOPROPYLACETAMIDINATO)NICKE&
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N,N'-Diisopropylcarbodiimide Suppliers

Global( 614)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BTC pharm India +918790379245 AndhraPradesh, India 1269 58 Inquiry
SURVIVAL TECHNOLOGIES LIMITED +91 8108285261 Gujarat, India 294 58 Inquiry
ORGANO FINE CHEMICALS +91-91-22-42128300 +91-2242128300 Mumbai, India 258 58 Inquiry
ADVENT CHEMBIO PRIVATE LIMITED +91-9821524116 +91-9821524116 Mumbai, India 353 58 Inquiry
NSJ Prayog Life Sciences Private Limited +91-6281747900 +91-6281747900 Hyderabad, India 76 58 Inquiry
Radison Labs Private Limited +91-7337551966 +91-7337551966 Hyderabad, India 58 58 Inquiry
Organo Fine Chemicals +91 (22) 2201-6968 / 2206-7521 New Delhi, India 266 60 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5873 58 Inquiry
Supplier Advantage
BTC pharm India 58
SURVIVAL TECHNOLOGIES LIMITED 58
ORGANO FINE CHEMICALS 58
ADVENT CHEMBIO PRIVATE LIMITED 58
NSJ Prayog Life Sciences Private Limited 58
Radison Labs Private Limited 58
Organo Fine Chemicals 60
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Otto Chemie Pvt. Ltd. 58

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N,N'-Diisopropylcarbodiimide Spectrum

N,N'-Diisopropylcarbodiimide(693-13-0)MSN,N'-Diisopropylcarbodiimide(693-13-0)1HNMRN,N'-Diisopropylcarbodiimide(693-13-0)13CNMRN,N'-Diisopropylcarbodiimide(693-13-0)IR1N,N'-Diisopropylcarbodiimide(693-13-0)Raman

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