N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide Properties

Melting point	210-2120C (dec)
Boiling point	145-148 °C(lit.)
Density	0.815 g/mL at 20 °C(lit.)
vapor pressure	34.9hPa at 55.46℃
refractive index	n20/D 1.433(lit.)
Flash point	93 °F
storage temp.	Store below +30°C.
solubility	Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
form	Liquid
color	Clear colorless to yellow
Sensitive	Moisture Sensitive
BRN	878281
Stability	Volatile
InChIKey	BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP	4.11 at 20℃
CAS DataBase Reference	693-13-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	OQO20I6TWH
NIST Chemistry Reference	2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA Substance Registry System	2-Propanamine, N,N'-methanetetraylbis- (693-13-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS06,GHS08

Signal word

Danger

Hazard statements

H226-H317-H318-H330-H334

Precautionary statements

P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

T+,T,F,Xn

Risk Statements

10-26-36/37/38-41-42/43-37/38

Safety Statements

26-36/37/39-45-38-28A-16-22

RIDADR

UN 2929 6.1/PG 1

WGK Germany

3

RTECS

FF2175000

F

10-21

Hazard Note

Flammable/Highly Toxic/

TSCA

Yes

HazardClass

6.1

PackingGroup

II

HS Code

29252000

Hazardous Substances Data

693-13-0(Hazardous Substances Data)

NFPA 704

	2
4		1

N,N'-Diisopropylcarbodiimide price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.03649	N,N′-Diisopropylcarbodiimide for synthesis	693-13-0	10ml	$51.3	2024-03-01	Buy
Sigma-Aldrich	8.03649	N,N′-Diisopropylcarbodiimide for synthesis	693-13-0	25mL	$99.5	2024-03-01	Buy
Sigma-Aldrich	8.03649	N,N′-Diisopropylcarbodiimide for synthesis	693-13-0	100mL	$261	2024-03-01	Buy
Sigma-Aldrich	8.03649	N,N′-Diisopropylcarbodiimide for synthesis	693-13-0	1L	$1170	2024-03-01	Buy
Sigma-Aldrich	38370	DIC purum, ≥98.0% (GC)	693-13-0	25ml	$89.6	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.03649	10ml	$51.3	Buy
8.03649	25mL	$99.5	Buy
8.03649	100mL	$261	Buy
8.03649	1L	$1170	Buy
38370	25ml	$89.6	Buy

N,N'-Diisopropylcarbodiimide Chemical Properties,Uses,Production

Description

Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.

Chemical Properties

N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.

Uses

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. It is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature.

Definition

ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.

General Description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Contact allergens

It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.

Synthesis

Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.
N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide synthesis

Synthesis of N,N'-Diisopropylcarbodiimide from N,N'-DIISOPROPYLTHIOUREA

N,N'-Diisopropylcarbodiimide Preparation Products And Raw materials

Raw materials

MOLECULAR SIEVES PACK 4A 1,2-DIETHOXYDISULFANE LEAD CARBONATE Benzene Dichloromethane

N,N'-DIISOPROPYLTHIOUREA

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Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE

4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE 2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA 4,5-Imidazolidinedione, 2,2-dichloro-1,3-bis(1-methylethyl)- BIS(N N'-DIISOPROPYLACETAMIDINATO)NICKE&

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N,N'-Diisopropylcarbodiimide Suppliers

Global( 625)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Z&T Chemical Co., Ltd	+86-021-33561011 +8613818804961	Sales@ztchemical.com.cn	China	402	58
Hangzhou Verychem Science And Technology Co.Ltd	+86-86-57188162785 13606544505	lucy@verychem.com	China	1059	58
Changzhou Zechong Biopharma Co., Ltd.	+undefined18621330623	sales@zechongchem.com	China	28	58
Hebei Weibang Biotechnology Co., Ltd	+8615350571055	Sibel@weibangbio.com	China	6087	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18151	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12834	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Shandong Juchuang Chemical Co., LTD	+undefined15030412209	admin@juchuangchem.com	China	387	58

Supplier	Advantage
Shanghai Z&T Chemical Co., Ltd	58
Hangzhou Verychem Science And Technology Co.Ltd	58
Changzhou Zechong Biopharma Co., Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Nantong Guangyuan Chemicl Co,Ltd	58
Shandong Juchuang Chemical Co., LTD	58

View Lastest Price from N,N'-Diisopropylcarbodiimide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-26	N,N'-Diisopropylcarbodiimide 693-13-0	US $100.00-75.00 / kg	1kg	99%	5000Ton	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2024-12-26	N,N'-Diisopropylcarbodiimide 693-13-0	US $79.00-38.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co Ltd
2024-12-24	N,N'-Diisopropylcarbodiimide 693-13-0	US $100.00 / kg	1kg	99%	1000	hebei hongtan Biotechnology Co., Ltd

N,N'-Diisopropylcarbodiimide
693-13-0
US $100.00-75.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

N,N'-Diisopropylcarbodiimide
693-13-0
US $79.00-38.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

N,N'-Diisopropylcarbodiimide
693-13-0
US $100.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

N,N'-Diisopropylcarbodiimide Spectrum

N,N'-Diisopropylcarbodiimide(693-13-0)MS N,N'-Diisopropylcarbodiimide(693-13-0)¹HNMR N,N'-Diisopropylcarbodiimide(693-13-0)¹³CNMR N,N'-Diisopropylcarbodiimide(693-13-0)IR1 N,N'-Diisopropylcarbodiimide(693-13-0)Raman

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