| Identification | More | [Name]
Diisopropylamine | [CAS]
108-18-9 | [Synonyms]
AURORA KA-7634
DIISOPROPYLAMINE
DIPA
LABOTEST-BB LTBB000412
(N-(1-METHYLETHYL)-2)PROPANAMINE
(iso-C3H7)2NH
2-Propanamine,N-(1-methylethyl)-
bis(1-methylethyl)amine
Bis(isopropyl)amine
Diisopropylamin
dipropylamine(non-specificname)
N-(1-Methylethyl)-2-propamine
n-(1-methylethyl)-2-propanamin
N,N-Diisopropylamine
N-Isopropyl-1-amino-2-methylethane
N-isopropyl-1-methylethanamine
N-isopropyl-2-propanamine
N-isopropyl-isopropylamine
Isodipropylamine
DIISOPROPYLAMINE, REDISTILLED, 99.95% | [EINECS(EC#)]
203-558-5 | [Molecular Formula]
C6H15N | [MDL Number]
MFCD00008862 | [Molecular Weight]
101.19 | [MOL File]
108-18-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid | [Melting point ]
-61 °C (lit.) | [Boiling point ]
84 °C (lit.) | [density ]
0.722 g/mL at 25 °C(lit.)
| [vapor density ]
3.5 (vs air)
| [vapor pressure ]
50 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.392(lit.)
| [Fp ]
1.4 °F
| [storage temp. ]
Store at RT. | [solubility ]
100 g/L (20°C) | [form ]
Liquid | [pka]
11.05(at 25℃) | [color ]
Clear colorless | [Odor]
Amine. | [PH]
11.8 (6g/l, H2O, 20℃) | [Stability:]
Stable. Flammable. Incompatible with strong oxidizing agents. May react violently with strong acids or oxidizers. Air sensitive. | [explosive limit]
1.1-7.1%(V) | [Water Solubility ]
100 g/L (20 ºC) | [Detection Methods]
GC | [Merck ]
14,3196 | [BRN ]
605284 | [Dielectric constant]
3.04 | [Exposure limits]
NIOSH REL: TWA 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 5
ppm; ACGIH TLV: TWA 5 ppm (adopted). | [InChIKey]
UAOMVDZJSHZZME-UHFFFAOYSA-N | [LogP]
0.4 at 20℃ | [CAS DataBase Reference]
108-18-9(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Propanamine, N-(1-methylethyl)-(108-18-9) | [EPA Substance Registry System]
108-18-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R20/22:Harmful by inhalation and if swallowed .
R34:Causes burns. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1158 3/PG 2
| [WGK Germany ]
2
| [RTECS ]
IM4025000
| [Autoignition Temperature]
599 °F | [Hazard Note ]
Highly Flammable/Corrosive/Harmful | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29211990 | [Safety Profile]
Moderately toxic by
ingestion and subcutaneous routes. Mildly
toxic by inhalation. Mutation data reported.
A skin and severe eye irritant. Inhalation of
fumes can cause pulmonary edema. A very
dangerous fire hazard when exposed to heat
or flame; can react vigorously with oxidizing
materials. To fight fire, use alcohol foam,foam, CO2, dry chemical. When heated to
decomposition it emits toxic fumes of NOx
See also AMINES. | [Hazardous Substances Data]
108-18-9(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 0.77 g/kg (Smyth) | [IDLA]
200 ppm |
| Hazard Information | Back Directory | [General Description]
A clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals. | [Reactivity Profile]
DIISOPROPYLAMINE(108-18-9) can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. | [Air & Water Reactions]
Highly flammable. Soluble in water. Sensitive to heat and air. | [Health Hazard]
Inhalation of vapors causes irritation, sometimes with nausea and vomiting; can also cause burns to the respiratory system. Ingestion causes irritation of mouth and stomach. Vapor irritates eyes; liquid causes severe burn, like caustic. Contact with skin causes irritation. | [Description]
Diisopropylamine is a secondary amine and is a colorless liquid at room temperature with a fishy, ammonia-like odor. It is used as a chemical intermediate, and catalyst for the synthesis of pesticides and pharmaceuticals. Diisopropylamine is associated with tobacco either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Synonyms for diisopropylamine include DIPA, and N-(1-methylethyl)-2- propanamine. | [Chemical Properties]
Diisopropylamine is a flammable, strongly alkaline Colorless liquid. Diisopropylamine is soluble in water and alcohol. The odor threshold ranges from 0.017 to 4.2 ppm; the fishlike odor becomes irritating at 100 mg/m3. | [Physical properties]
Colorless liquid with an ammonia-like odor. Experimentally determined detection and recognition
odor threshold concentrations were 50 μg/m3 (130 ppbv) and 190 μg/m3 (380 ppbv), respectively
(Hellman and Small, 1974). | [Uses]
Chemical intermediate; used to adjust
the pH of cosmetic formulations | [Uses]
Diisopropylamine is used as a solvent
and in the chemical synthesis of dyes, pharmaceuticals, and
other organic syntheses. | [Application]
Diisopropylamine is used as a solvent and in the chemical synthesis of dyes, pharmaceuticals, and other organic syntheses. It used to synthesize diisopropylamine methyl urea (DMU), N,N-diisopropyl quinoline-2-carboxamide, 3-N-sulfonylamidine coumarins and N-chloroamine, an intermediate to generate amides. | [Preparation]
Synthesis of diisopropylamine: using acetone, ammonia and hydrogen as raw materials, and reacting at 150-220 ° C under normal pressure with nickel, copper and clay as catalysts, the conversion rate of acetone is 98%, and the crude products of mono- and diisopropylamine are obtained, After rectification, Isopropylamine and diisopropylamine were obtained. | [Production Methods]
Diisopropylamine is produced by the reaction of diisopropyl alcohol with ammonia
(HSDB 1989). | [Chemical Reactivity]
Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Industrial uses]
Diisopropylamine is used as a catalyst and as a stabilizer for mesityl oxide (HSDB
1989). It is also used as an intermediate in the synthesis of dyes, pharmaceuticals
and pesticides (e.g. Diallate, Fenamiphos and Triallate). | [Potential Exposure]
Mutagen. Thismaterial is used in the preparation of vapor-phase inhibitorsand rubber accelerators; as a chemical intermediate in thesynthesis of pharmaceuticals and pesticides (diallate, fenamiphos, and triallate, for example). | [First aid]
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin,remove contaminated clothing and wash immediately withsoap and water. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, beginrescue breathing (using universal precautions, includingresuscitation mask) if breathing has stopped and CPR if heartaction has stopped. Transfer promptly to a medical facility.When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Donot make an unconscious person vomit. Medical observationis recommended for 24-48 h after breathing overexposure,as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consideradministering a corticosteroid spray. | [Environmental Fate]
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Reacts with acids forming water-soluble salts. | [Metabolism]
Little, if any investigation of the metabolism of short-chain aliphatic amines has
been reported and the best that can be done is to suggest some possible metabolic
routes. For example the flavin monooxygenase system could produce the hydroxylamine
through N-hydroxylation catalyzed by the flavin monooxygenase system
(Ziegler 1988). N-hydroxylation can also be induced with the cytochrome P-450
system as can N-dealkylation reactions (Lindeke and Cho 1982). More definitive
analysis must await experimental studies. | [storage]
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with DIPA you should be trained on itsproper handling and storage. Before entering confined spacewhere this chemical may be present, check to make surethat an explosive concentration does not exist.Diisopropylamine must be stored to avoid contact withstrong acids (such as hydrochloric, sulfuric, and nitric) oroxidizers (such as perchlorates, peroxides, permanganates,chlorates, and nitrates) because violent reactions occur.Store in tightly closed containers in a cool, well-ventilatedarea away from heat. Sources of ignition, such as smokingand open flames, are prohibited where diisopropylamine isused, handled, or stored in a manner that could create apotential fire or explosion hazard. Metal containers involving the transfer of=gallons or more of diisopropylamineshould be grounded and bonded. Drums must be equippedwith self-closing valves, pressure vacuum bungs, and flamearresters. Use only nonsparking tools and equipment, especially when opening and closing containers ofdiisopropylamine. | [Shipping]
This compound requires a shipping label of“FLAMMABLE LIQUID, CORROSIVE.” It falls inHazard Class 3 and Packing Group II. | [Purification Methods]
Distil the amine from NaOH, or reflux it three minutes over Na wire or NaH, and distil it into a dry receiver under N2. [Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.] | [Incompatibilities]
Forms explosive mixture with air. Thischemical is a strong base; reacts violently with strong oxidizers, strong acids. Attacks copper, zinc and their alloys, aluminum, and galvanized steel. Attacks some forms ofplastics and coatings. |
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