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2-Chloronicotinic acid

2-Chloronicotinic acid Structure
CAS No.
2942-59-8
Chemical Name:
2-Chloronicotinic acid
Synonyms
2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;2 - chloro niacin;AKOS BBS-00004231;oronicotinic acid;TIMTEC-BB SBB004002;RARECHEM AL BO 0287
CBNumber:
CB7714896
Molecular Formula:
C6H4ClNO2
Molecular Weight:
157.55
MOL File:
2942-59-8.mol
MSDS File:
SDS
Modify Date:
2024/7/24 13:33:21

2-Chloronicotinic acid Properties

Melting point 176-178 °C (dec.)(lit.)
Boiling point 316.8±22.0 °C(Predicted)
Density 1.470±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO, Ethyl Acetate (Slightly)
pka 2.07±0.25(Predicted)
form Powder
color White to cream
BRN 119023
InChI InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)
InChIKey IBRSSZOHCGUTHI-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC=C1C(O)=O
LogP 0.988
CAS DataBase Reference 2942-59-8(CAS DataBase Reference)
EPA Substance Registry System 2-Chloronicotinic acid (2942-59-8)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-37/39-26-36
WGK Germany  3
TSCA  T
HazardClass  IRRITANT
HS Code  29333999
NFPA 704
0
2 0

2-Chloronicotinic acid price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 150339 2-Chloropyridine-3-carboxylic acid 99% 2942-59-8 10G ₹2143.35 2022-06-14 Buy
Sigma-Aldrich(India) 150339 2-Chloropyridine-3-carboxylic acid 99% 2942-59-8 10G ₹2143.35 2022-06-14 Buy
Sigma-Aldrich(India) PHR2305 Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material 2942-59-8 50MG ₹45529.95 2022-06-14 Buy
Sigma-Aldrich 150339 2-Chloropyridine-3-carboxylic acid 99% 2942-59-8 50G ₹6332.63 2022-06-14 Buy
Sigma-Aldrich(India) 150339 2-Chloropyridine-3-carboxylic acid 99% 2942-59-8 50G ₹6332.63 2022-06-14 Buy
Product number Packaging Price Buy
150339 10G ₹2143.35 Buy
150339 10G ₹2143.35 Buy
PHR2305 50MG ₹45529.95 Buy
150339 50G ₹6332.63 Buy
150339 50G ₹6332.63 Buy

2-Chloronicotinic acid Chemical Properties,Uses,Production

Chemical Properties

white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.

Uses

2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.

Preparation

Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.

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