2-Chloronicotinic acid
![2-Chloronicotinic acid Structure](CAS/GIF/2942-59-8.gif)
- CAS No.
- 2942-59-8
- Chemical Name:
- 2-Chloronicotinic acid
- Synonyms
- 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;2 - chloro niacin;AKOS BBS-00004231;oronicotinic acid;TIMTEC-BB SBB004002;RARECHEM AL BO 0287
- CBNumber:
- CB7714896
- Molecular Formula:
- C6H4ClNO2
- Molecular Weight:
- 157.55
- MOL File:
- 2942-59-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 13:33:21
Melting point | 176-178 °C (dec.)(lit.) |
---|---|
Boiling point | 316.8±22.0 °C(Predicted) |
Density | 1.470±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO, Ethyl Acetate (Slightly) |
pka | 2.07±0.25(Predicted) |
form | Powder |
color | White to cream |
BRN | 119023 |
InChI | InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10) |
InChIKey | IBRSSZOHCGUTHI-UHFFFAOYSA-N |
SMILES | C1(Cl)=NC=CC=C1C(O)=O |
LogP | 0.988 |
CAS DataBase Reference | 2942-59-8(CAS DataBase Reference) |
EPA Substance Registry System | 2-Chloronicotinic acid (2942-59-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 22-24/25-37/39-26-36 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | T | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29333999 | |||||||||
NFPA 704 |
|
2-Chloronicotinic acid price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 150339 | 2-Chloropyridine-3-carboxylic acid 99% | 2942-59-8 | 10G | ₹2143.35 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 150339 | 2-Chloropyridine-3-carboxylic acid 99% | 2942-59-8 | 10G | ₹2143.35 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR2305 | Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 2942-59-8 | 50MG | ₹45529.95 | 2022-06-14 | Buy |
Sigma-Aldrich | 150339 | 2-Chloropyridine-3-carboxylic acid 99% | 2942-59-8 | 50G | ₹6332.63 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 150339 | 2-Chloropyridine-3-carboxylic acid 99% | 2942-59-8 | 50G | ₹6332.63 | 2022-06-14 | Buy |
2-Chloronicotinic acid Chemical Properties,Uses,Production
Chemical Properties
white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.
Uses
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.
Preparation
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.
2-Chloronicotinic acid Preparation Products And Raw materials
Raw materials
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BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
N S CHEMICALS AND CONSULTANTS PVT LTD | +91-9867708201 +91-9867708201 | Maharashtra, India | 18 | 58 | Inquiry |
Hyderabad | +91-9676447615 +91-9676447615 | Telangana, India | 192 | 58 | Inquiry |
Island Veer Chemie Pvt Ltd | +917093280665 | Telangana, India | 32 | 58 | Inquiry |
Varna Chems | +91-9030000693 +91-9030000693 | Hyderabad, India | 483 | 58 | Inquiry |
CHATURYA BIOTECH | +91-7702707258 +91-7702707258 | Telangana, India | 479 | 58 | Inquiry |
Reliance Rasayan Pvt Ltd | +91-9427160241 +91-9427160241 | Gujarat, India | 21 | 58 | Inquiry |
JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
Supplier | Advantage |
---|---|
BTC pharm India | 58 |
GLR Innovations | 58 |
N S CHEMICALS AND CONSULTANTS PVT LTD | 58 |
Hyderabad | 58 |
Island Veer Chemie Pvt Ltd | 58 |
Varna Chems | 58 |
CHATURYA BIOTECH | 58 |
Reliance Rasayan Pvt Ltd | 58 |
JSK Chemicals | 58 |
VGS SYNTHESIS PRIVATE LIMITED | 58 |
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