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Epichlorohydrin

Epichlorohydrin Structure
CAS No.
106-89-8
Chemical Name:
Epichlorohydrin
Synonyms
ECH;2-(Chloromethyl)oxirane;EPICHLOROHYDRINE;EPICHLORHYDRIN;1-CHLORO-2,3-EPOXYPROPANE;Epichlorhydrine;ALPHA-EPICHLOROHYDRIN;New product 99.9% purity CAS 106-89-8 Epichlorohydrin CAS NO.106-89-8 Manufacturers wholesale;Epicloridrina;J006
CBNumber:
CB8381781
Molecular Formula:
C3H5ClO
Molecular Weight:
92.52
MOL File:
106-89-8.mol
MSDS File:
SDS
Modify Date:
2024/5/11 20:10:50
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Epichlorohydrin Properties

Melting point -57 °C
alpha -1～+1°(D/20℃)(c=1,CH3OH)
Boiling point 115-117 °C(lit.)
Density 1.183 g/mL at 25 °C(lit.)
vapor density 3.2 (vs air)
vapor pressure 13.8 mm Hg ( 21.1 °C)
refractive index n20/D 1.438(lit.)
Flash point 93 °F
storage temp. Store below +30°C.
solubility 65.9g/l
form Liquid
color APHA: ≤20
Specific Gravity 1.183 (20/4℃)
Odor Pungent, garlic; sweet, pungent; like chloroform.
explosive limit 3.8-21%(V)
Water Solubility 6 g/100 mL (10 ºC)
FreezingPoint -57.2℃
Merck 14,3611
BRN 79785
Henry's Law Constant 3.42(x 10-5 atm?m3/mol) at 25 °C (static headspace-GC, Welke et al., 1998)
Exposure limits TLV-TWA(skin) 8 mg/m3 (2 ppm) (ACGIH); STEL (15 min) 19 mg/m3 (5 ppm) (NIOSH).
Dielectric constant 22.9（20℃）
Stability Unstable. Flammable - note wide explosion limits and low flash point.
LogP 0.45 at 20℃
CAS DataBase Reference 106-89-8(CAS DataBase Reference)
IARC 2A (Vol. 11, Sup 7, 71) 1999
NIST Chemistry Reference Oxirane, (chloromethyl)-(106-89-8)
EPA Substance Registry System Epichlorohydrin (106-89-8)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H301+H311+H331-H314-H317-H350
Precautionary statements  P201-P210-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  45-10-23/24/25-34-43
Safety Statements  53-45
RIDADR  UN 2023 6.1/PG 2
WGK Germany  3
RTECS  TX4900000
Autoignition Temperature 779 °F
TSCA  Yes
HS Code  2910 30 00
HazardClass  6.1
PackingGroup  II
Toxicity LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter)
IDLA 75 ppm
NFPA 704
3
3 2

Epichlorohydrin price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.03296 Epichlorohydrine for synthesis 106-89-8 100ML ₹7260 2022-06-14 Buy
Sigma-Aldrich(India) 8.03296 Epichlorohydrine for synthesis 106-89-8 1L ₹7920 2022-06-14 Buy
Sigma-Aldrich(India) 8.03296 Epichlorohydrine for synthesis 106-89-8 500ML ₹10790.01 2022-06-14 Buy
Sigma-Aldrich(India) 8.03296 Epichlorohydrine for synthesis 106-89-8 8L ₹22990 2022-06-14 Buy
Sigma-Aldrich(India) 8.03296 Epichlorohydrine for synthesis 106-89-8 30KG ₹68770.01 2022-06-14 Buy
Product number Packaging Price Buy
8.03296 100ML ₹7260 Buy
8.03296 1L ₹7920 Buy
8.03296 500ML ₹10790.01 Buy
8.03296 8L ₹22990 Buy
8.03296 30KG ₹68770.01 Buy

Epichlorohydrin Chemical Properties,Uses,Production

Description

Epoxy resins of the bisphenol A type are synthesized from epichlorhydrin and bisphenol A. This leads to bisphenol-A diglycidyl ether, which is the monomer of bisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers in the epoxy-resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has however been described to occur after contact with a soil fumigant, due to solvent cement and in a worker in a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was used for the production of both drugs propranolol and oxprenolol.

Chemical Properties

Epichlorohydrin is a colorless liquid with a slightly irritating, chloroform-like odor.

Physical properties

Clear, colorless, mobile liquid with a strong, irritating, chloroform-like odor. Odor threshold concentration is 0.93 ppm (quoted, Amoore and Hautala, 1983).

Uses

Epichlorohydrin is used to make glycerol,epoxy resins, adhesive, and castings; asderivatives for producing dyes, pharmaceu-ticals, surfactants, and plasticizers; and asa solvent for resins, gums, paints, andvarnishes.

Production Methods

Epichlorohydrin can be prepared from 1,3-dichloropropanol-2, 2,3- dichloropropanol-1, or allyl chloride. Commercially it is prepared as an intermediate in glycerol synthesis via alkaline hydrolysis of glycerol dichlorohydrin. Both come from allyl chloride. Epichlorohydrin reacts with monohydric alcohols to give ethers by opening the oxide ring. It will react with ethers, aldehydes, ketones, organic acids and amines to give a wide variety of useful syntheses.

Definition

ChEBI: An epoxide that is 1,2-epoxypropene in which one of the methyl hydrogens is substituted by chlorine.

General Description

A clear colorless liquid with an irritating chloroform-like odor. Density 9.8 lb / gal. Flash point 87°F. Polymerizable. If polymerization takes place inside a closed container, the container is subject to violent rupture. Irritates the skin and respiratory system. Toxic by ingestion. A confirmed carcinogen. Vapors heavier than air. Used to make plastics and as a solvent.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

Epichlorohydrin may polymerize exothermically if heated or contaminated. Reacts explosively with aniline. Ignites on contact with potassium tert-butoxide. Reacts with trichloroethylene to give the explosive dichloroacetylene. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids or bases, zinc, aluminum, aluminum chloride, iron, ferric chloride [Sax, 9th ed., 1996, p. 1469].

Hazard

Toxic by inhalation, ingestion, and skin absorption; strong irritant, a carcinogen. Flammable, moderate fire risk. TLV: 0.5 ppm; animal carcinogen.

Health Hazard

Epichlorohydrin is caustic as both a liquid and gas. Irritation of the eyes and skin, and skin sensitization has been observed. Exposure to epichlorohydrin has caused inflammation of the lungs, asthmatic bronchitis, and liver and kidney damage. In acute poisonings, death may be caused by respiratory paralysis.

Fire Hazard

When heated to decomposition, Epichlorohydrin evolves highly toxic fumes of phosgene and carbon monoxide. Reactive and incompatible with strong oxidizers, strong acids, caustics, zinc, aluminum, chlorides of iron and aluminumand compounds with an active hydrogen atom, including water. Unstable, avoid heat, contaminants, strong acids and bases, certain curing agents such as ethylenediamine. Hazardous polymerization may occur.

Chemical Reactivity

Reactivity with Water Mild reaction; not likely to be hazardous; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Can polymerize in presence of strong acids and bases, particularly when hot; Inhibitor of Polymerization: None used.

Contact allergens

Epoxy resin of the Bisphenol A type is synthesized from epichlorhydrin and bisphenol A. It leads to bisphenol A diglycidyl ether, which is the monomer ofbisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers of the epoxy resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has, however, been described to occur following exposure to a soil fumigant, due to solvent cement, and in a worker in a pharmaceutical plant, in a division of drug synthesis. Epichlorhydrin was used for the production of drugs propranolol and oxprenolol.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Moderately toxic by inhalation. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by inhalation: respiratory, nose, and eyes. Human mutation data reported. A skin and eye irritant. A sensitizer. Flammable liquid when exposed to heat or flame. Explosive reaction with andine. Reaction with trichloroethylene forms the explosive dichloroacetylene. Ignition on contact with potassium tertbutoxide. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids, caustic alkalies, aluminum, aluminum chloride, iron(II1) chloride, or zinc. When heated to decomposition it emits toxic fumes of Cl

Potential Exposure

Epichlorohydrin, an organochlorine, is used in the manufacture of many glycerol and glycidol derivatives and epoxy resins; as a stabilizer in chlorine-containing materials; as an intermediate in the preparation of cellulose esters and ethers, paints, varnishes, nail enamels, and lacquers; as a cement for celluloid. It is used as an intermediate in the manufacture of various drugs. Increased cancer risk.

Carcinogenicity

Epichlorohydrin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Biological. Bridié et al. (1979) reported BOD and COD values of 0.03 and 1.16 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. When a sewage seed was used in a separate screening test, a BOD value of 0.16 g/g was obtained. The ThOD for epichlorohydrin is 1.21 g/g.
Chemical/Physical. Anticipated products from the reaction of epichlorohydrin with ozone or OH radicals in the atmosphere are formaldehyde, glyoxylic acid, and ClCH2O(O)OHCHO (Cupitt, 1980). Haag and Yao (1992) reported a calculated OH radical rate constant in water of 2.9 x 108/M?sec.

storage

Epichlorohydrin is stored in a well-ventilated,cool place isolated from combustible andoxidizable materials, all acids and bases,and anhydrous metal halides. Protect fromphysical damage. It is shipped in metaldrums.

Shipping

UN2023 Epichlorhydrin, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3-Flammable liquid.

Purification Methods

Distil epichlorohydrin under atmospheric pressure, heat it on a steam bath with one-quarter its weight of CaO, then decant and fractionally distil it. [Beilstein 17 V 20.]

Incompatibilities

May form explosive mixture with air. Slowly decomposes on contact with water. Heat or strong acids; alkalies, metallic halides, or contaminants can cause explosive polymerization. Violent reaction with strong oxidizers, aliphatic amines; alkanolamines, amines (especially aniline), alkaline earths; chemically active metals (chlorides of aluminum, iron zinc); powdered metals (aluminum, zinc); alcohols, phenols, organic acids; causing fire and explosion hazard. Will pit steel in the presence of water. Thermal decomposition forms highly toxic phosgene gas. May accumulate static electrical charges, and may cause ignition of its vapors.

Waste Disposal

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal

Epichlorohydrin Preparation Products And Raw materials

Raw materials

2,3-DICHLORO-1-PROPANOL Calcium carbonate 2-Amino-3-chlorobenzoic acid PROPYLENE Chlorine
Oxygen D-D Extender Acetic acid Sodium hydroxide hypochlorous acid
Allyl chloride Sodium carbonate
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Preparation Products

4-(oxiranylmethoxy)-1H-indole CARAZOLOL HCL Finishing agent FS 1,4-bis[(3-chloro-2-hydroxypropyl)amino]anthraquinone noncyanide zie plating additive XD-2
2-GLYCIDYLOXYBENZONITRILE Glycidyl phenyl ether L-Carnitine hydrochloride L-Carnitine fumarate 2,3-DIHYDRO-1,4-BENZODIOXIN-2-METHANOL 4-METHYLBENZENESULFONATE
Noncyanide zinc plating additive DE zinc plating additive DPE-1 softening agent EST Guaiacol glycidyl ether Metoprolol
ironicion stabilzer Ethylene glycol diglycidyl ether 2-HYDROXYMETHYL-1,4-BENZODIOXANE 2-[(1-Naphthyloxy)methyl]oxirane 1,3-diiodopropan-2-ol
mnocyanide zine plating bright agent 1-(2-Hydroxy-3-sulfopropyl)-pyridinium betane 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride Poly(epichlorohydrin-co-propylene oxide-co-starch) DL-Carnitine hydrochloride
softening agent SCI-A noncyanide zinc plating bright additive 1-CHLORO-3-FLUOROISOPROPANOL [[p-(2-methoxyethyl)phenoxy]methyl]oxirane N-(4-(OXIRANYLMETHOXY)-1,2-EPOXYPROPANE
Cross-linking agent DE noncyanide zinc plating additive-TDAE noncyanide zinc plating additive XD-1 GLYCIDYL ISOPROPYL ETHER 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE
BE-strong efficient nickel plating brightener 1,3,5-Triglycidyl isocyanurate Acetyl-L-carnitine hydrochloride the chelating resin of crosslinking chitosan condense with salilylaldehyde wet strength agent used for paper PAE
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Epichlorohydrin Suppliers

Global( 787)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
Sudarshan Pharma Industries Limited +91-2242221111 +91-9320932107 Maharashtra, India 37 58 Inquiry
Nikava Pharmaceutical Industries +91-9653317212 +91-9653317212 Mumbai, India 20 58 Inquiry
Soham Chemical Industries +91-7016081644 +91-7016081644 Mumbai, India 83 58 Inquiry
P C SHROFF AND CO +91-9825066948 +91-9825066948 Gujarat, India 11 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Sri Neelima Laboratories +91-7981733602 +91-9849736989 Telangana, India 205 58 Inquiry
Meghmani Finechem Ltd +91-7929709600 +91-7929709600 Ahmedabad, India 9 58 Inquiry
Enrich Chemicals 08048617310 Mumbai, India 4 58 Inquiry
Nikava Pharmaceutical Industries 08048957599 Maharashtra, India 13 58 Inquiry
Supplier Advantage
GLR Innovations 58
Sudarshan Pharma Industries Limited 58
Nikava Pharmaceutical Industries 58
Soham Chemical Industries 58
P C SHROFF AND CO 58
JSK Chemicals 58
Sri Neelima Laboratories 58
Meghmani Finechem Ltd 58
Enrich Chemicals 58
Nikava Pharmaceutical Industries 58

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