Metoprolol
- CAS No.
- 37350-58-6
- Chemical Name:
- Metoprolol
- Synonyms
- cgp2175;Metroprolol;Metoprolol Base;H-23/96;CGP 2175;metoprol;Metoprorol;Metoprolol;Methoprorol;Lopresoretic
- CBNumber:
- CB4165974
- Molecular Formula:
- C15H25NO3
- Molecular Weight:
- 267.36
- MOL File:
- 37350-58-6.mol
- Modify Date:
- 2023/11/24 18:23:39
| Boiling point | 410.55°C (rough estimate) |
|---|---|
| Density | 1.0281 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| CAS DataBase Reference | 37350-58-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Metoprolol(37350-58-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H335-H315-H302-H228-H361-H319-H332 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P210-P240-P241-P280-P370+P378-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501 |
Metoprolol Chemical Properties,Uses,Production
Uses
Metoprolol is a β-adrenergic blocking antihypertensive and antianginal agent; to treat raised blood pressure; to prevent attacks of angina (pain from an inadequate oxygen supply to the heart); after a heart attack to prevent further damage to the heart muscle; treatment of some disturbances of heart rhythm; used to help prevent attacks of migraine; in ophthalmic preparations; treatment of myocardial infarcts.
Mechanism of action
Unlike propranolol, which blocks both β1 and β2-adrenoreceptors, metroprolol exhibits cardioselective action, i.e. in therapeutic doses, it blocks β1-adrenoreceptors with insignificant effects on β2-adrenoreceptors.
Metabolism
The pharmacokinetic profile of metoprolol (Lopressor) is similar to that of propranolol. Metoprolol is readily and rapidly absorbed after oral administration and is subject to a significant amount of first-pass metabolism by the liver. Curiously, the duration of metoprolol’s action is longer than one would predict from its plasma half-life, which ranges from 0.5 to 2.5 hours. The degree of binding of metoprolol to plasma proteins is modest (10%). The extensive distribution of metoprolol to the lungs and kidney is typical of a moderately lipophilic drug. Metoprolol undergoes considerable metabolism;only 3 to 10% of an administered dose is recovered as unchanged drug.The metabolites are essentially inactive as -receptor blocking agents and are eliminated primarily by renal excretion. Small amounts of the drug are present in the feces.
Metoprolol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| ChemBioReas Life Sciences | +91-7989264158 +91-7989264158 | Hyderabad, India | 82 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Zydus Lifesciences Ltd. | +91-0265-2315243 +91-6358895661 | Gujarat, India | 89 | 58 | Inquiry |
| Atul Bioscience Ltd | +91-9316723499 +91-9316723499 | Maharashtra, India | 43 | 58 | Inquiry |
| Lavybens Pharma | +91-8790466757 +91-8790466756 | Telangana, India | 80 | 58 | Inquiry |
| Heer Pharma Pvt Ltd | +91-9820051881 +91-9820051881 | Maharashtra, India | 102 | 58 | Inquiry |
| Sibram Pharmaceutical | +91-8655777550 +91-8655777550 | Maharashtra, India | 244 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| AVD pharmaceuticals Pvt Ltd | 58 |
| ChemBioReas Life Sciences | 58 |
| J S LABS | 58 |
| AARTIA KEM SCIENCE | 58 |
| Varanous Labs Pvt Ltd | 58 |
| Zydus Lifesciences Ltd. | 58 |
| Atul Bioscience Ltd | 58 |
| Lavybens Pharma | 58 |
| Heer Pharma Pvt Ltd | 58 |
| Sibram Pharmaceutical | 58 |