PROMETHAZINE
- CAS No.
- 60-87-7
- Chemical Name:
- PROMETHAZINE
- Synonyms
- Promethazin;Isopromethazine;Aprobit;Dimapp;Fargan;Procit;Prorex;WY 509;3277 RP;A-91033
- CBNumber:
- CB9744071
- Molecular Formula:
- C17H20N2S
- Molecular Weight:
- 284.42
- MOL File:
- 60-87-7.mol
- Modify Date:
- 2024/8/15 19:00:21
| Melting point | 60℃ |
|---|---|
| Boiling point | bp3 190-192° |
| Density | 1.131 |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | pKa 9.1(H2O,t undefined) (Uncertain) |
| color | Pale Beige to Pale Brown |
| Water Solubility | 383.9ug/L(22.5 ºC) |
| EPA Substance Registry System | Promethazine (60-87-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS09,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318-H317-H411 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| Toxicity | LD50 oral in rabbit: 580mg/kg |
PROMETHAZINE Chemical Properties,Uses,Production
Description
As a derivative of phenothiazine, promethazine is structurally and pharmacologically similar to chlorpromazine. It exhibits strong antihistamine activity as well as expressed action on the CNS. It potentiates action of sedative and analgesic drugs.
Uses
Promethazine is used for treating allergic illnesses such as hives, serum disease, hay fever, dermatosis, and also for rheumatism with expressed allergic components, for allergic complications caused by antibiotics and other medicinal drugs, and for enhancing action of analgesics and local anesthetics. Synonyms of this drug are allergen, phenergan, pipolphen, prothazine, and others.
Definition
ChEBI: A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
World Health Organization (WHO)
Introduced in 1946, promethazine, a phenothiazine derivative has a variety of pharmacological properties. At present it is mainly used as an antihistamine and anti-motion-sickness drug. Promethazine is listed in the WHO Model List of Essential Drugs.
General Description
Crystals. Melting point 60°C. Used as an antihistaminic.
Air & Water Reactions
Turns blue on prolonged exposure to air and moisture.
Reactivity Profile
PROMETHAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable or toxic gases may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: Symptoms of PROMETHAZINE include leucopenia; agranulocytosis; confusion; convulsions; stupor; and it potentiates the action of central nervous system depressants.
Fire Hazard
Flash point data for PROMETHAZINE are not available, however PROMETHAZINE is probably combustible.
Clinical Use
Promethazine, an early agent in the series, has many useful pharmacological affects other than being an antihistamine. It has significant antiemetic and anticholinergic properties. It also has sedative-hypnotic properties and has been used to potentiate the effects of analgesic drugs. Subsequent analogues, such as trimeprazine and methdilazine, are used as antipruritic agents in the treatment of urticaria.
Safety Profile
Poison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effectsHuman mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx
PROMETHAZINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| K Kumar & Co. | 08068442317Ext 609 | Kolkata, India | 6 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5831 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | China | 341 | 58 | Inquiry |
| Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 | China | 935 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
60-87-7(PROMETHAZINE)Related Search:
1of4
chevron_right