Promethazine hydrochloride
- CAS No.
- 58-33-3
- Chemical Name:
- Promethazine hydrochloride
- Synonyms
- PROMETHAZINE HCL;Phena;PHENERGAN;remsed;promine;N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride;dorme;atosil;hl8700;ganphen
- CBNumber:
- CB0725983
- Molecular Formula:
- C17H21ClN2S
- Molecular Weight:
- 320.88
- MOL File:
- 58-33-3.mol
- Modify Date:
- 2024/8/4 20:11:12
| Melting point | 230-232°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride. |
| form | Solid |
| color | White to Almost white |
| PH | pH (50g/L, 25℃) : 4.0～6.0 |
| λmax | 297nm(H2O)(lit.) |
| Merck | 14,7786 |
| BRN | 4166397 |
| BCS Class | 1,3 |
| InChI | InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| SMILES | N1(CC(C)N(C)C)C2C=CC=CC=2SC2=CC=CC=C12.Cl |
| CAS DataBase Reference | 58-33-3(CAS DataBase Reference) |
| EPA Substance Registry System | Promethazine hydrochloride (58-33-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318-H411 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-36/37/38-51/53-43-20/22 | |||||||||
| Safety Statements | 26-36-61-60-36/37/39-28-22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SO8225000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29343000 | |||||||||
| Toxicity | LD50 i.v. in mice: 55.0 mg/kg (Rajsner) | |||||||||
| NFPA 704 |
|
Promethazine hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P4651 | Promethazine hydrochloride | 58-33-3 | 25G | ₹6733.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1467 | Promethazine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 58-33-3 | 1G | ₹8313.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P4651 | Promethazine hydrochloride | 58-33-3 | 100G | ₹17991.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P-111 | Promethazine hydrochloride solution 1.0?mg/mL (1% 1 M HCl in Methanol (as free base)), ampule of 1?mL, certified reference material, Cerilliant? | 58-33-3 | 1ML | ₹625.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46682 | Promethazine hydrochloride VETRANAL?, analytical standard | 58-33-3 | 100MG | ₹10651.8 | 2022-06-14 | Buy |
Promethazine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic; in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as central nervous system depressant; in pills, syrup, injections and suppositories.
Definition
ChEBI: The hydrochloride salt of promethazine.
General Description
Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0.
Air & Water Reactions
Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble.
Reactivity Profile
Promethazine hydrochloride is sensitive to light. In aqueous solution, Promethazine hydrochloride is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation .
Fire Hazard
Flash point data for Promethazine hydrochloride are not available; however, Promethazine hydrochloride is probably combustible.
Safety Profile
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: excitement, sleep, convulsions, rigdity. Experimental teratogenic effects. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl, SOx, and NOx. Used as an antihstamine.
Promethazine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Harika Drugs Pvt Ltd | +91-4023814863 +91-4023814863 | Telangana, India | 19 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CADILA HEALTHCARE LTD | +91 2718 225001 | New Delhi, India | 110 | 58 | Inquiry |
| IPCA LABORATORIES LTD | +91 (22) 6210 5000 | New Delhi, India | 43 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Related articles
- Promethazine Hydrochloride: Overview
- Promethazine hydrochloride is a white to faint yellow, crystalline powder. It is practically odorless and has a bitter taste.
- Jul 31，2024
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