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ChemicalBook > Product Catalogue >API >Antiallergic drugs >Antihistamines >Promethazine hydrochloride

Promethazine hydrochloride

Promethazine hydrochloride  Structure
  • ₹625.1 - ₹17991.15
  • Product name: Promethazine hydrochloride
  • CAS: 58-33-3
  • MF: C17H21ClN2S
  • MW: 320.88
  • EINECS:200-375-2
  • MDL Number:MFCD00012652
  • Synonyms:10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HYDROCHLORIDE;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride ;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride ;promethazinen-(2’-dimethylamino-2’-methylethyl)phenothiazinehydrochloride ;promethiazin ;pyrethia ;romegranhydrochloride
7 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 1G
  • 1ML
  • 25G
  • 100G
  • ManufacturerTCI Chemicals (India)
  • Product numberP2029
  • Product descriptionPromethazine Hydrochloride
  • Packaging25G
  • Price₹4100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2029
  • Product descriptionPromethazine Hydrochloride
  • Packaging100G
  • Price₹8800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP-111
  • Product descriptionPromethazine hydrochloride solution 1.0?mg/mL (1% 1 M HCl in Methanol (as free base)), ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹625.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP4651
  • Product descriptionPromethazine hydrochloride
  • Packaging25G
  • Price₹6733.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1467
  • Product descriptionPromethazine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8313.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number46682
  • Product descriptionPromethazine hydrochloride VETRANAL?, analytical standard
  • Packaging100MG
  • Price₹10651.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP4651
  • Product descriptionPromethazine hydrochloride
  • Packaging100G
  • Price₹17991.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2029 Promethazine Hydrochloride 25G ₹4100 2022-05-26 Buy
TCI Chemicals (India) P2029 Promethazine Hydrochloride 100G ₹8800 2022-05-26 Buy
Sigma-Aldrich(India) P-111 Promethazine hydrochloride solution 1.0?mg/mL (1% 1 M HCl in Methanol (as free base)), ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹625.1 2022-06-14 Buy
Sigma-Aldrich(India) P4651 Promethazine hydrochloride 25G ₹6733.15 2022-06-14 Buy
Sigma-Aldrich(India) PHR1467 Promethazine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8313.6 2022-06-14 Buy
Sigma-Aldrich(India) 46682 Promethazine hydrochloride VETRANAL?, analytical standard 100MG ₹10651.8 2022-06-14 Buy
Sigma-Aldrich(India) P4651 Promethazine hydrochloride 100G ₹17991.15 2022-06-14 Buy

Properties

Melting point :230-232°C
Flash point :9℃
storage temp. :2-8°C
solubility :Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
form :Solid
color :White to Almost white
PH :pH (50g/L, 25℃) : 4.0~6.0
λmax :297nm(H2O)(lit.)
Merck :14,7786
BRN :4166397
BCS Class :1,3
InChI :InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
InChIKey :XXPDBLUZJRXNNZ-UHFFFAOYSA-N
SMILES :N1(CC(C)N(C)C)C2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference :58-33-3(CAS DataBase Reference)
EPA Substance Registry System :Promethazine hydrochloride (58-33-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.

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