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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >Topotecan hydrochloride

Topotecan hydrochloride

Topotecan hydrochloride Structure
  • ₹0
  • Product name: Topotecan hydrochloride
  • CAS: 119413-54-6
  • MF: C23H24ClN3O5
  • MW: 457.91
  • EINECS:601-607-9
  • MDL Number:MFCD00866235
  • Synonyms:1,4-di(4-benzhydryloxy-2-butynyl)piperazine;1,4-di(4-benzyloxy-2-butynyl)piperazine;(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-(H-Pyrano[3' , 4':6,7]indolizino[1,2-b]quinoline-3,14[4H,12H]-dione monohydrochloride;Topotecan Hydrochloride（TPT）;S-(6-thioxo-1,6-dihydro-pyrimidin-4-yl)-isothiourea;Topotecan hydrochloride(NSC-609699);Topotecan, Hydrochloride Salt;Toputecan hydrochloride
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :213-218°C
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form :Light yellow to greenish powder.
color :White to Off-White
Stability :Hygroscopic
CAS DataBase Reference :119413-54-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Topotecan is a water soluble analog of the alkaloid camptothecin that potently inhibits DNA topoisomerase I. It induces cytoxicity and DNA damage in human HT-29 colon adenocarcinoma cells with IC50 values of 33 nM and 0.28 μM, respectively. Topotecan demonstrates a broad spectrum of antitumor activity against a variety of other tumors including ovarian cancer, cervical cancer, neuroblastoma, brainstem glioma, and Ewing’s sarcoma.

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Suppliers and manufacturers

Avra Laboratories Pvt Ltd Basil Drugs AND Pharmaceuticals Pvt Ltd Raising Sun Pharma Fresenius Kabi Oncology Limited A.J Chemicals CLEARSYNTH LABS LTD. CHEMSWORTH Pharmaffiliates Analytics and Synthetics P. Ltd Geekay Agriuno Haryana Leather Chemicals Limited