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ChemicalBook > Product Catalogue >Biochemical Engineering >Natural Products >Irinotecan hydrochloride trihydrate

Irinotecan hydrochloride trihydrate

Irinotecan hydrochloride trihydrate Structure
  • ₹11800 - ₹136089
  • Product name: Irinotecan hydrochloride trihydrate
  • CAS: 136572-09-3
  • MF: C33H45ClN4O9
  • MW: 677.18
  • EINECS:603-967-2
  • MDL Number:MFCD01765731
  • Synonyms:Irinotecan-d10 hydrochloride trihydrate;CPT-11 HCl Trihydrate;irinotecan hydrochloride hydrate;Irinotecanhydrochloridetrihydrate(CPT-11);IRINOTECON HCL TRIHYDRATE;[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE;(S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%;Irinotecan Hydrochloride (100 mg)
2 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • ottokemi

Package

  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberI0714
  • Product descriptionIrinotecan Hydrochloride Trihydrate
  • Packaging100MG
  • Price₹11800
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number I 0692
  • Product descriptionIrinotecan hydrochloride
  • Packaging100mg
  • Price₹136089
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) I0714 Irinotecan Hydrochloride Trihydrate 100MG ₹11800 2022-05-26 Buy
ottokemi I 0692 Irinotecan hydrochloride 100mg ₹136089 2022-05-26 Buy

Properties

Melting point :250-256°C (dec.)
Boiling point :257°C(lit.)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
form :White solid.
color :Yellow
Water Solubility :Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck :14,5091
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference :136572-09-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P403 Store in a well-ventilated place.

Description

Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3

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