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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Other antineoplastic Drugs >Oxaliplatin

Oxaliplatin

Oxaliplatin Structure
  • ₹12864.9 - ₹29981.1
  • Product name: Oxaliplatin
  • CAS: 61825-94-3
  • MF: C8H12N2O4Pt
  • MW: 395.28
  • EINECS:621-248-1
  • MDL Number:MFCD00866327
  • Synonyms:[SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM;OXALIPLATIN;trans-l-diaminocyclohexane oxalatoplatinum;(1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr ;oxalato(1r,2r-cyclohexanediammine)platinum(ii) ;oxalatoplatin ;[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N,)[ethanedioato(2-)-O,O’Jplatinum;NSC-266046:Elocatin
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 5MG
  • 100MG
  • 200MG
  • ManufacturerTCI Chemicals (India)
  • Product numberO0372
  • Product descriptionOxaliplatin
  • Packaging100MG
  • Price₹16200
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO9512
  • Product descriptionOxaliplatin powder
  • Packaging5MG
  • Price₹12864.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1528
  • Product descriptionOxaliplatin Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging200MG
  • Price₹29981.1
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number O 0449
  • Product descriptionOxaliplatin 99%
  • Packaging5mg
  • Price₹24039
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) O0372 Oxaliplatin 100MG ₹16200 2022-05-26 Buy
Sigma-Aldrich(India) O9512 Oxaliplatin powder 5MG ₹12864.9 2022-06-14 Buy
Sigma-Aldrich(India) PHR1528 Oxaliplatin Pharmaceutical Secondary Standard; Certified Reference Material 200MG ₹29981.1 2022-06-14 Buy
ottokemi O 0449 Oxaliplatin 99% 5mg ₹24039 2022-05-26 Buy

Properties

alpha :+74.5-78.0 (D/20)(c=0.5,H2O)
storage temp. :2-8°C
solubility :Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
form :solid
color :White to Almost white
Water Solubility :Soluble in water with heating and/or sonication
Merck :14,6912
Stability :Stable. Store cool. Incompatible with oxidizing agents.
InChI :InChI=1/C6H12N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-8H,1-4H2;(H,3,4)(H,5,6);/q-2;;+4/p-2/t5-,6-;;/s3
InChIKey :ZROHGHOFXNOHSO-BNTLRKBRSA-L
SMILES :O=C1C([O-][Pt+2]2(N[C@]3([H])CCCC[C@@]3([H])N2)[O-]1)=O |&1:6,12,r|
CAS DataBase Reference :61825-94-3

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.

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