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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >Docetaxel

Docetaxel

Docetaxel Structure
  • ₹14004 - ₹47079
  • Product name: Docetaxel
  • CAS: 114977-28-5
  • MF: C43H53NO14
  • MW: 807.88
  • EINECS:601-339-2
  • MDL Number:MFCD00871399
  • Synonyms:Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-;Docetaxel N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol;Taxotere anhydrous;n-debenzoyl-n-tert-butoxycarbonyl-10-deacetyl taxol;)benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph ;Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih ydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-;DOCETAXEL ANHYDROUS 99.5%;Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
4 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number01885
  • Product descriptionDocetaxel purum, ≥97.0% (HPLC)
  • Packaging5MG
  • Price₹15945.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number01885
  • Product descriptionDocetaxel purum, ≥97.0% (HPLC)
  • Packaging25MG
  • Price₹40842.73
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number D 2402
  • Product descriptionDocetaxel+ 97%
  • Packaging5mg
  • Price₹14004
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number D 2402
  • Product descriptionDocetaxel+ 97%
  • Packaging25mg
  • Price₹47079
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 01885 Docetaxel purum, ≥97.0% (HPLC) 5MG ₹15945.23 2022-06-14 Buy
Sigma-Aldrich(India) 01885 Docetaxel purum, ≥97.0% (HPLC) 25MG ₹40842.73 2022-06-14 Buy
ottokemi D 2402 Docetaxel+ 97% 5mg ₹14004 2022-05-26 Buy
ottokemi D 2402 Docetaxel+ 97% 25mg ₹47079 2022-05-26 Buy

Properties

Melting point :186-192 °C (dec.)
alpha :-36 º (c=0.74,EtOH)
Boiling point :900.5±65.0 °C(Predicted)
Density :1.38
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
form :Solid
pka :11.20±0.46(Predicted)
color :White
Water Solubility :Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
Merck :14,3397
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :BEDLLNJKXXVTSX-LWWLJZAUSA-N
LogP :2.456 (est)
CAS DataBase Reference :114977-28-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM). It has proven more effective than taxol in preventing the proliferation of cancer cells. Docetaxel has applications in breast cancer and hormone-refractory prostate cancer. This product is intended for research applications.

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