Oxaliplatin
Oxaliplatin
- CAS:
- 61825-94-3
- MF:
- C8H12N2O4Pt
- MW:
- 395.28
Suppliers by country/region
Company Type
Properties
- alpha
- +74.5-78.0 (D/20)(c=0.5,H2O)
- storage temp.
- 2-8°C
- solubility
- Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
- form
- solid
- color
- White to Almost white
- Water Solubility
- Soluble in water with heating and/or sonication
- Merck
- 14,6912
- Stability:
- Stable. Store cool. Incompatible with oxidizing agents.
- InChI
- InChI=1/C6H12N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-8H,1-4H2;(H,3,4)(H,5,6);/q-2;;+4/p-2/t5-,6-;;/s3
- InChIKey
- ZROHGHOFXNOHSO-BNTLRKBRSA-L
- SMILES
- O=C1C([O-][Pt+2]2(N[C@]3([H])CCCC[C@@]3([H])N2)[O-]1)=O |&1:6,12,r|
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H315-H317-H319-H335-H340-H360D
- Precautionary statements
- P202-P261-P280-P302+P352-P305+P351+P338-P308+P313
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-40-42/43
- Safety Statements
- 26-36
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- TP2275850
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 28439000
- Toxicity
- LD50 intraperitoneal in mouse: 19800ug/kg
Use
Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.
19 India supplier list of "Oxaliplatin"
- Product Name:Oxaliplatin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Karnataka,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1MT
- Company Type: Manufacturer
- Country/Region: West Bengal,INDIA
- Product Name:Oxaliplatin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA