Docetaxel
Docetaxel
- CAS:
- 114977-28-5
- MF:
- C43H53NO14
- MW:
- 807.88
Suppliers by country/region
Company Type
Properties
- Melting point:
- 186-192 °C (dec.)
- alpha
- -36 º (c=0.74,EtOH)
- Boiling point:
- 900.5±65.0 °C(Predicted)
- Density
- 1.38
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
- form
- Solid
- pka
- 11.20±0.46(Predicted)
- color
- White
- Water Solubility
- Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
- Merck
- 14,3397
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- BEDLLNJKXXVTSX-LWWLJZAUSA-N
- LogP
- 2.456 (est)
- CAS DataBase Reference
- 114977-28-5(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H315-H319-H341-H360D-H362-H372
- Precautionary statements
- P202-P260-P263-P302+P352-P305+P351+P338-P308+P313
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-61
- Safety Statements
- 26-36/37-53-45
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- DA4172750
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29322090
- Hazardous Substances Data
- 114977-28-5(Hazardous Substances Data)
- Toxicity
- LD50 intravenous in dog: 2500ug/kg
Use
Docetaxel, a semi-synthetic product from the taxoid family, was launched in 1995 first in South Africa and subsequently in several other markets for the treatment of ovarian, breast and non-small cell lung cancers. Like the naturally occurring antitumor agent paclitaxel, the first marketed taxoid, docetaxel promotes both the rate and extent of tubulin assembly into stable microtubules and inhibits their depolymerization. It acts as a mitotic spindle poison and induces a mitotic block in proliferating cells. This mechanism of action for taxoids is unique from other classes of anticancer agents. Docetaxel was reported to be twice as potent as paclitaxel in several in vitro protocols and also exhibit higher cytotoxicity. Clinical trials are on going for docetaxel for other types of tumors including pancreatic, gastric, head and neck cancers and soft tissue sarcomas.
69 India supplier list of "Docetaxel"
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: AndhraPradesh,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Mumbai,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:Docetaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA