Paclitaxel
Paclitaxel
- CAS:
- 33069-62-4
- MF:
- C47H51NO14
- MW:
- 853.92
Suppliers by country/region
- India(90)
- China(462)
- United States(109)
- United Kingdom(30)
- Canada(12)
- Germany(11)
- France(5)
- Europe(5)
- Japan(4)
- Switzerland(5)
- South Korea(9)
- Australia(1)
- Belgium(2)
- Israel(2)
- Brazil(4)
- Czech Republic(4)
- Slovenia(1)
- Italy(2)
- Poland(1)
- Singapore(1)
- Austria(1)
- Uruguay(1)
- Greece(1)
- Malaysia(1)
- Spain(1)
- United Arab Emirates(1)
- Czech(1)
- Mexico(1)
Company Type
Properties
- Melting point:
- 213 °C (dec.)(lit.)
- alpha
- D20 -49° (methanol)
- Boiling point:
- 774.66°C (rough estimate)
- Density
- 0.200
- refractive index
- -49 ° (C=1, MeOH)
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- methanol: 50 mg/mL, clear, colorless
- form
- powder
- pka
- 11.90±0.20(Predicted)
- color
- white
- Water Solubility
- 0.3mg/L(37 ºC)
- λmax
- 227nm(MeOH)(lit.)
- Merck
- 14,6982
- BRN
- 1420457
- Stability:
- Stable. Incompatible with strong oxidizing agents. Combustible.
- InChIKey
- RCINICONZNJXQF-MZXODVADSA-N
- LogP
- 3.950 (est)
Safety Information
- Symbol(GHS)
GHS05,GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H315-H317-H318-H334-H335-H340-H360D-H372
- Precautionary statements
- P202-P260-P280-P302+P352-P305+P351+P338-P308+P313
- Hazard Codes
- Xn
- Risk Statements
- 37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
- Safety Statements
- 22-26-36/37/39-45
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- DA8340700
- F
- 10-21
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29329990
- Toxicity
- LD50 intraperitoneal in mouse: 128mg/kg
Use
Paclitaxel (commercial name, Taxol) a complex diterpene alkaloid isnaturally obtained from Taxus species (family Taxaceae). Paclitaxel has been provedas highly effective in the treatment of various types of cancers, since it acts as amicrotubule-stabilizing agent to protect against disassembly. Paclitaxel was developed by the National Cancer Institute, USA, as a drug for cancer therapy andused for the treatment of refractory ovarian cancer, metastatic breast and lung cancer,and Kaposi’s sarcoma (Srivastava et al. 2005). The natural source of paclitaxelis the bark of several Taxus species; however, the cost of extraction is very highsince the concentration of paclitaxel accumulation is very low (0.02% of dry weight)and also entails the destruction of natural resources (Cusido et al. 2014). Eventhough, paclitaxel can be chemically synthesized, but this process is not commerciallyviable. Plant cell cultures have been developed for the production of paclitaxelby Phyton Biotech in 1995, and in 2004 the FDA has approved the use of plantculture supply of paclitaxel/Taxol (Leone and Roberts 2013).
90 India supplier list of "Paclitaxel"
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Haryana,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Mumbai,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Reagent
- Country/Region: Himachal Pradesh,INDIA
- Product Name:Paclitaxel
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA