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ChemicalBook > Product Catalogue >Biochemical Engineering >Nucleoside drugs >Nucleotides and their analogs >5-Fluorouracil

5-Fluorouracil

5-Fluorouracil Structure
  • ₹396 - ₹146330
  • Product name: 5-Fluorouracil
  • CAS: 51-21-8
  • MF: C4H3FN2O2
  • MW: 130.08
  • EINECS:200-085-6
  • MDL Number:MFCD00006018
  • Synonyms:2,4(1H,3H)-Pyrimidinedione, 5-fluoro-;2,4-dioxo-5-fluoropyrimidine ;3h)-pyrimidinedione,5-fluoro-4(1h ;5-faracil ;fluoro-uracile ;fluoro-uracilo ;fluorouracilum ;Fluracilum
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  • ManufacturerSigma-Aldrich
  • Product number343922
  • Product description5-Fluorouracil - CAS 51-21-8 - Calbiochem Potent antitumor agent.
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  • Price₹7830
  • Updated2022-06-14
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  • ManufacturerALFA India
  • Product numberALF-A13456-06
  • Product description5-Fluorouracil, 99%
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  • Price₹5657
  • Updated2022-05-26
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  • ManufacturerALFA India
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  • Product description5-Fluorouracil, 99%
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  • ManufacturerALFA India
  • Product numberALF-A13456-22
  • Product description5-Fluorouracil, 99%
  • Packaging100g
  • Price₹146330
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  • ManufacturerTCI Chemicals (India)
  • Product numberF0151
  • Product description5-Fluorouracil
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  • ManufacturerTCI Chemicals (India)
  • Product numberF0151
  • Product description5-Fluorouracil
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  • Price₹7000
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  • ManufacturerSigma-Aldrich(India)
  • Product numberF6627
  • Product description5-Fluorouracil ≥99% (HPLC), powder
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  • Price₹2706.25
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  • ManufacturerSigma-Aldrich(India)
  • Product number03738
  • Product description5-Fluorouracil analytical standard
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  • Price₹5260.95
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  • ManufacturerSigma-Aldrich(India)
  • Product number343922
  • Product description5-Fluorouracil - CAS 51-21-8 - Calbiochem Potent antitumor agent.
  • Packaging1G
  • Price₹7830
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberF6627
  • Product description5-Fluorouracil ≥99% (HPLC), powder
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  • Price₹9320.33
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  • ManufacturerSigma-Aldrich(India)
  • Product number8.18505
  • Product description5-Fluorouracil for synthesis
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  • Price₹11050
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  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1227
  • Product descriptionFluorouracil Pharmaceutical Secondary Standard; Certified Reference Material
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  • Price₹11355.43
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  • ManufacturerSigma-Aldrich(India)
  • Product numberF8423
  • Product descriptionFluorouracil meets USP testing specifications
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  • Price₹12535.35
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  • ManufacturerSigma-Aldrich(India)
  • Product number04541
  • Product description5-Fluorouracil certified reference material, TraceCERT?
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  • Price₹15393.15
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  • ManufacturerSigma-Aldrich(India)
  • Product numberF6627
  • Product description5-Fluorouracil ≥99% (HPLC), powder
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  • Price₹17222.58
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  • ManufacturerSigma-Aldrich(India)
  • Product numberF8423
  • Product descriptionFluorouracil meets USP testing specifications
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  • Price₹23306.23
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Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 343922 5-Fluorouracil - CAS 51-21-8 - Calbiochem Potent antitumor agent. 1G ₹7830 2022-06-14 Buy
ALFA India ALF-A13456-06 5-Fluorouracil, 99% 5g ₹5657 2022-05-26 Buy
ALFA India ALF-A13456-14 5-Fluorouracil, 99% 25g ₹21242 2022-05-26 Buy
ALFA India ALF-A13456-22 5-Fluorouracil, 99% 100g ₹146330 2022-05-26 Buy
TCI Chemicals (India) F0151 5-Fluorouracil 5G ₹2500 2022-05-26 Buy
TCI Chemicals (India) F0151 5-Fluorouracil 25G ₹7000 2022-05-26 Buy
Sigma-Aldrich(India) F6627 5-Fluorouracil ≥99% (HPLC), powder 1G ₹2706.25 2022-06-14 Buy
Sigma-Aldrich(India) 03738 5-Fluorouracil analytical standard 100MG ₹5260.95 2022-06-14 Buy
Sigma-Aldrich(India) 343922 5-Fluorouracil - CAS 51-21-8 - Calbiochem Potent antitumor agent. 1G ₹7830 2022-06-14 Buy
Sigma-Aldrich(India) F6627 5-Fluorouracil ≥99% (HPLC), powder 5G ₹9320.33 2022-06-14 Buy
Sigma-Aldrich(India) 8.18505 5-Fluorouracil for synthesis 5G ₹11050 2022-06-14 Buy
Sigma-Aldrich(India) PHR1227 Fluorouracil Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹11355.43 2022-06-14 Buy
Sigma-Aldrich(India) F8423 Fluorouracil meets USP testing specifications 5G ₹12535.35 2022-06-14 Buy
Sigma-Aldrich(India) 04541 5-Fluorouracil certified reference material, TraceCERT? 50MG ₹15393.15 2022-06-14 Buy
Sigma-Aldrich(India) F6627 5-Fluorouracil ≥99% (HPLC), powder 10G ₹17222.58 2022-06-14 Buy
Sigma-Aldrich(India) F8423 Fluorouracil meets USP testing specifications 10G ₹23306.23 2022-06-14 Buy

Properties

Melting point :282-286 °C (dec.) (lit.)
Boiling point :190-200°C/0.1mmHg
Density :1.4593 (estimate)
storage temp. :2-8°C
solubility :H2O: 10 mg/mL, clear
form :powder
pka :pKa 8.0±0.1 (H2O) (Uncertain);3.0±0.1(H2O) (Uncertain)
color :white
PH :4.3-5.3 (10g/l, H2O, 20℃)
Water Solubility :12.2 g/L 20 ºC
Sensitive :Air Sensitive
Merck :14,4181
BRN :127172
Stability :Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey :GHASVSINZRGABV-UHFFFAOYSA-N
CAS DataBase Reference :51-21-8(CAS DataBase Reference)
IARC :3 (Vol. 26, Sup 7) 1987
NIST Chemistry Reference :2,4-Pyrimidinedione, 5-fluoro-(51-21-8)
EPA Substance Registry System :5-Fluorouracil (51-21-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

5-Fluorouracil is a pyrimadine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. 5-Fluorouracil has been widely used to treat many gastrointestinal tract adenocarcinomas. However, its clinical application is greatly limited due to drug resistance.

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