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ChemicalBook > Product Catalogue >API >Inhibitors >Crizotinib

Crizotinib

Crizotinib Structure
  • ₹13174.03
  • Product name: Crizotinib
  • CAS: 877399-52-5
  • MF: C21H22Cl2FN5O
  • MW: 450.34
  • EINECS:638-814-9
  • MDL Number:MFCD12407409
  • Synonyms:(R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylaMine;[3-[[(R)-1-(2,6-Dichloro-3- fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]aMine;2-PyridinaMine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;Crozotinib;Crizotinib,PF-02341066;Crizotinib (PF2341066);PF-02341066 Crizotinib;3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0191
  • Product descriptionCrizotinib ≥98% (HPLC)
  • Packaging5MG
  • Price₹13174.03
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0191 Crizotinib ≥98% (HPLC) 5MG ₹13174.03 2022-06-14 Buy

Properties

Melting point :192 °C
Boiling point :599.2±50.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming)
pka :9.81±0.10(Predicted)
form :powder
color :white to tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChIKey :KTEIFNKAUNYNJU-GFCCVEGCSA-N
SMILES :C1(N)=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C
CAS DataBase Reference :877399-52-5

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. In August 2011, the United States FDA approved crizotinib for the treatment of anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer (NSCLC).

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Suppliers and manufacturers

Jigs Chemical ltd AVD pharmaceuticals Pvt Ltd Bulat Pharmaceutical Pvt Ltd Apothecon Pharmaceuticals Pvt Ltd Rivashaa Agrotech Biopharma Pvt. Ltd. Shreyaa Medilife Private Limited Apicore Pharmaceuticals Pvt Ltd Aspen Biopharma Labs Pvt Ltd AKASH PHARMA EXPORTS Arunodaya Pharma Pvt., Ltd.