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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >Ceritinib (LDK378)

Ceritinib (LDK378)

Ceritinib (LDK378) Structure
  • ₹0
  • Product name: Ceritinib (LDK378)
  • CAS: 1032900-25-6
  • MF: C28H36ClN5O3S
  • MW: 558.14
  • EINECS:811-457-8
  • MDL Number:MFCD26142648
  • Synonyms:Eritinib;5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)p;Ceritinib (LDK378);LDK 378 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine;Eritinib (LDK378);Ceritinib, >=98%;LDK37;CS-819
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :173-175°C
Boiling point :720.7±70.0 °C(Predicted)
Density :1.251±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :10.16±0.10(Predicted)
form :Off-white solid.
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ceritinib (previously LDK378l, brand name Zykadia; Novartis Pharmaceuticals) is an oral small molecule tyrosine kinase inhibitor of ALK [87]. Preclinical studies suggested that it would inhibit ROS1 as well [88, 89].

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Suppliers and manufacturers

AVD pharmaceuticals Pvt Ltd Varanous Labs Pvt Ltd CHEMAZON LABORATORIES Aspen Biopharma Labs Pvt Ltd A.J Chemicals CLEARSYNTH LABS LTD. SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd Pharma Affiliates MSN LABORATORIES PRIVATE LTD