Vandetanib
- ₹0
- Product name: Vandetanib
- CAS: 443913-73-3
- MF: C22H24BrFN4O2
- MW: 475.35
- EINECS:669-841-4
- MDL Number:MFCD07772346
- Synonyms:7-((4-aminocyclohexyl)methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine;Vandetanib(Zactima),ZD6474;Vandetanib(ZactiMa,AZD6474);Vandetanib base;N-(4-BroMo-2-fluorophenyl)-6-Methoxy-7-[(1-Methylpiperidin-4-yl)Methoxy]-4-aMino-quinazoline;Vandetanib (ZactiMa);ZD6474; ZACTIMA;VANDETANIB
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Melting point :240-2430C
Boiling point :538.2±50.0 °C(Predicted)
Density :1.406
Flash point :279.3℃
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)
pka :8.92±0.10(Predicted)
form :solid
color :White to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :UHTHHESEBZOYNR-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(OC)C(OCC3CCN(C)CC3)=C2)=C(NC2=CC=C(Br)C=C2F)N=C1
CAS DataBase Reference :443913-73-3
Boiling point :538.2±50.0 °C(Predicted)
Density :1.406
Flash point :279.3℃
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (30 mg/ml); Ethanol (10 mg/ml with warming)
pka :8.92±0.10(Predicted)
form :solid
color :White to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :UHTHHESEBZOYNR-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(OC)C(OCC3CCN(C)CC3)=C2)=C(NC2=CC=C(Br)C=C2F)N=C1
CAS DataBase Reference :443913-73-3
Safety Information
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Signal word: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Description
Vandetanib is a broad spectrum, orally available kinase inhibitor that targets primarily tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR), with IC50 values in the nanomolar range. It also potently blocks non-receptor tyrosine kinases, including ABL, RET, and SRC, as well as several serine/threonine kinases. Primarily because of its effects on receptor tyrosine kinases like VEGFR and EGFR, vandetanib inhibits angiogenesis, cell growth, and metastasis and is effective against certain forms of cancer.More related product prices
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