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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >Alectinib

Alectinib

Alectinib Structure
  • ₹0
  • Product name: Alectinib
  • CAS: 1256580-46-7
  • MF: C30H34N4O2
  • MW: 482.62
  • EINECS:821-541-6
  • MDL Number:MFCD19440988
  • Synonyms:AF-802;CH-5424802/RG-7853;Alectinib;AF-802,RG-7853;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802);CH5424802-alectinib;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CH5424802;CH5424802, Alectinib, AF802
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :274-276°C
Boiling point :722.5±60.0 °C(Predicted)
Density :1.28
storage temp. :-20°
solubility :Soluble in DMSO (up to 5 mg/ml with warming).
form :solid
pka :13.70±0.40(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. CH5424802 is an ATP-competitive inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively). It shows more than 500-fold selectivity for ALK over a panel of 24 other kinases. CH5424802 is orally available and inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma.

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