Alectinib
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- ₹0
- Product name: Alectinib
- CAS: 1256580-46-7
- MF: C30H34N4O2
- MW: 482.62
- EINECS:821-541-6
- MDL Number:MFCD19440988
- Synonyms:AF-802;CH-5424802/RG-7853;Alectinib;AF-802,RG-7853;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802);CH5424802-alectinib;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CH5424802;CH5424802, Alectinib, AF802
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Properties
Melting point :274-276°C
Boiling point :722.5±60.0 °C(Predicted)
Density :1.28
storage temp. :-20°
solubility :Soluble in DMSO (up to 5 mg/ml with warming).
form :solid
pka :13.70±0.40(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.
Boiling point :722.5±60.0 °C(Predicted)
Density :1.28
storage temp. :-20°
solubility :Soluble in DMSO (up to 5 mg/ml with warming).
form :solid
pka :13.70±0.40(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.
Safety Information
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Description
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. CH5424802 is an ATP-competitive inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively). It shows more than 500-fold selectivity for ALK over a panel of 24 other kinases. CH5424802 is orally available and inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma.More related product prices
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