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Alectinib

Alectinib Structure
CAS No.
1256580-46-7
Chemical Name:
Alectinib
Synonyms
Alecensa;Alecitinib;Alectinib (CH5424802);AF-802;CS-217;canna*;RG-7853;alectinb;Aletinib;Alectinib
CBNumber:
CB62534680
Molecular Formula:
C30H34N4O2
Molecular Weight:
482.62
MOL File:
1256580-46-7.mol
Modify Date:
2024/5/20 14:06:47
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Alectinib Properties

Melting point 274-276°C
Boiling point 722.5±60.0 °C(Predicted)
Density 1.28
storage temp. -20°
solubility Soluble in DMSO (up to 5 mg/ml with warming).
form solid
pka 13.70±0.40(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361-H341-H373
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501-P260-P314-P501
HS Code  2934999090

Alectinib Chemical Properties,Uses,Production

Description

Alectinib is another selective ALK inhibitor that is able to overcome resistance mutations from prior crizotinib exposure [38].

Chemical Properties

White to Off-White Solid

Indications

Alectinib (Alecensa(R), Roche) was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.

Definition

ChEBI: An organic heterotetracyclic compound that is 6,6-dimethyl-5,6-dihydro-11H-benzo[b]carbazol-11-one carrying additional cyano, 4-(morpholin-4-yl)piperidin-1-yl and ethyl substituents at positions 3, 8 and 9 respectively. Used (as the hydr chloride salt) for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell lung cancer.

brand name

Alecensa?

General Description

Class: receptor tyrosine kinase; Treatment: NSCLC; Oral bioavailability = 37%; Elimination half-life = 33 h; Protein binding = >99%

target

Primary targets: ALK (IC50 = 1.9 nM)/RET (IC50 = 4.8 nM)

Alectinib Preparation Products And Raw materials

Raw materials

4-Morpholinopiperidine 9-broMo-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile 9-ethynyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile Diethylzinc Trimethylsilylacetylene
Morpholine
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Preparation Products

Alectinib Hydrochloride

Alectinib Suppliers

Global( 307)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
AVD pharmaceuticals Pvt Ltd +919860835260 Pune, India 102 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Aspen Biopharma Labs Pvt Ltd +91-9248058660 +91-9248058662 Telangana, India 234 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
Supplier Advantage
AVD pharmaceuticals Pvt Ltd 58
Dr. Reddy's Laboratories Ltd 58
Aspen Biopharma Labs Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Capot Chemical Co.,Ltd. 60
Hangzhou FandaChem Co.,Ltd. 55

Related articles

  • What is Alectinib?
  • Alectinib (trade name Alecensa) is a new type of highly selective ALK-TKI, which was approved by the US FDA on December 11, 20....
  • Dec 26，2019

Alectinib Spectrum

Alectinib(1256580-46-7)1HNMR

1256580-46-7(Alectinib)Related Search:

PLX4032 4-Morpholinopiperidine tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate Alectinib Hydrochloride Ceritinib
Erlotinib hydrochloride AP26113 Ibrutinib Crizotinib AZD-9291
Neratinib LEE011 EAI-045 Nintedanib PLX-4720
Alectinib-d8 Alectinib Impurity 1 Alectinib Impurity 2 Ch5424802
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AF-802 CH-5424802/RG-7853 Alectinib AF-802,RG-7853 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802) CH5424802-alectinib 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CH5424802 CH5424802, Alectinib, AF802 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile 9-ETHYL-6,6-DIMETHYL-8-(4-MORPHOLINOPIPERIDIN-1-YL)-11-OXO-6,11-DIHYDRO-5H-BENZO[B]CARBAZOLE-3-CARBONITRILE CH5424802 AF 802; AF-802; AF802; CH5424802; CH5424802; CH 5424802; RO5424802; RO 5424802; RO5424802, ALECTINIB; BRAND NAME: ALECENSA brand name: Alecensa RO 5424802 RO5424802 RO5424802, Alectinib RG-7853 AF-802; CH 5424802; CH-5424802; AF802; AF 802 alectinb CS-217 Alectinib free base 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile 5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo- 9-Ethyl-6,6-dimethyl-8-(4-morpholino-1-piperidyl)-11-oxo-5H-benzobcarbazole-3-carbonitrile Alectinib USP/EP/BP 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib Alectinib (AF-802, CH-5424802, RO-5424802, Alecensa) canna* Alectinib (CH5424802) Alecensa Alecitinib Elle, on behalf of, Alectinib free base Alectinib base Aletinib 1256580-46-7 Anti-cancer&immunity Inhibitors API API