ChemicalBook > Product Catalog >API >Antineoplastic agents >Tinib Antineoplastic drugs >Neratinib

Neratinib

CAS No.: 698387-09-6

Chemical Name:: Neratinib

Synonyms: (2e)-n-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide;CS-26;PB-272;101028;neratinib;nevatinib;PF-0528767;WAY-179272;Unii-jjh94R3pwb;Neratinib Base.

CBNumber:: CB2855051

Molecular Formula:: C30H29ClN6O3

Molecular Weight:: 557.04

MOL File:: 698387-09-6.mol

Modify Date:: 2024/5/23 13:03:59

Request For Quotation

Neratinib Properties

Melting point	185-187°C
Boiling point	757.0±60.0 °C(Predicted)
Density	1.33
storage temp.	Refrigerator
solubility	Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
form	Off-white solid.
pka	12.37±0.43(Predicted)
color	Pale Yellow to Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H314-H290
Precautionary statements	P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
HS Code	29334900

Neratinib Chemical Properties,Uses,Production

Description

The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC₅₀ = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib . Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.

Characteristics

Class: receptor tyrosine kinase
Treatment: HER2-positive breast cancer
Elimination half-life = 14.6 h
Protein binding = 99%

Uses

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.

Definition

ChEBI: A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an ethoxy group at the 7-position.

Neratinib Preparation Products And Raw materials

Raw materials

2-(DIMETHYLAMINO)ACETALDEHYDE Phosphonic acid, P-[2-[[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]amino]-2-oxoethyl]-, diethyl ester 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile

Preparation Products

Neratinib Suppliers

Global( 365)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Clearsynth Labs	91-22-45045900	Maharashtra, India	3889	58	Inquiry
DR. Madhukar Pharmaceuticals (P) Limited	91-9867265882	Maharashtra, India	13	58	Inquiry
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)	91-22-42361111	Maharashtra, India	147	58	Inquiry
CLEANCHEM LABORATORIES LLP	+91 98921 69560	New Delhi, India	326	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	China	294	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Clearsynth Labs	58
DR. Madhukar Pharmaceuticals (P) Limited	58
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)	58
CLEANCHEM LABORATORIES LLP	58
Pharma Affiliates	58
shandong perfect biotechnology co.ltd	58

Neratinib- pharmacology
Neratinib is an oral pan HER inhibitor that irreversibly inhibits the tyrosine kinase activity of epidermal growth factor rece....
Dec 13，2019

Neratinib Spectrum

Neratinib(698387-09-6)MS Neratinib(698387-09-6)¹HNMR

698387-09-6(Neratinib)Related Search:

AZD-9291 n-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile Lenvatinib Tofacitinib

Axitinib Paclitaxel Gefitinib Bortezomib ABT 263

Ibrutinib Crizotinib Afatinib Lapatinib Ditosylate 3-chloro-4-(pyridin-2-ylmethoxy)aniline

Neratinib Ethoxyquin 4-(pyridin-2-ylmethoxy)aniline

chevron_left

1of4

chevron_right

Neratinib(HKI-272) (2E)-N-[4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]aMino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(diMethylaMino)-2-butenaMide neratinib (E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide Unii-jjh94R3pwb (2e)-n-(4-((3-chloro-4-((pyridin-2-yl)Methoxy)phenyl)aMino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(diMethylaMino)but-2-enaMide neratinib HKI-272 Neratinib Neratinib HKI-272 (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide Neratinib (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-emide PB272(neratinib) 2-ButenaMide,N-[4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]aMino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(diMethylaMino)-,(2E)- Neratinib, >=99% PB-272 PF-0528767 WAY-179272 (E)-N-(4-(3-Chloro-4-(pyridin-2-yLmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimet Neratinib USP/EP/BP Lenatinib Impurity E 101028 nevatinib Neratinib, 99%, a highly selective HER2 and EGFR inhibitor Neratinib API and intermediates CS-26 HKI-272; HKI272; HKI 272 (2e)-n-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide Neratinib Base. 698387-09-6 688387-09-6 C30H29ClN6O3 C30H31ClN6O2 Inhibitors Anti-cancer & immunity Antineoplastic API