ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >Bcl-2 inhibitors >ABT 263
ABT 263
![ABT 263 Structure](CAS/GIF/923564-51-6.gif)
- CAS No.
- 923564-51-6
- Chemical Name:
- ABT 263
- Synonyms
- Navitoclax;Navitoclax (ABT-263);ABT 263;CS-1871;CS-1967;Navitoclax-D8;ABT263;ABT-263;Navitoclax, >=98%;ABT 263 USP/EP/BP;ABT-263,Navitoclax
- CBNumber:
- CB21872884
- Molecular Formula:
- C47H55ClF3N5O6S3
- Molecular Weight:
- 974.61
- MOL File:
- 923564-51-6.mol
- Modify Date:
- 2023/12/6 9:15:57
Melting point | 114-116°C |
---|---|
Density | 1.41±0.1 g/cm3(Predicted) |
storage temp. | -20°C Freezer, Under Inert Atmosphere |
solubility | Soluble in DMSO (up to 25 mg/ml). |
form | solid |
pka | 4.60±0.10(Predicted) |
color | White |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
CAS DataBase Reference | 923564-51-6 |
ABT 263 Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.
Mechanism of action
ABT‐263 exerts its senolytic activity in senescent tumor cells by inhibiting BCL‐XL's interaction with BAX. ABT‐263 is a BH3 mimetic that inhibits anti‐apoptotic BCL‐2 family proteins by impeding their ability to bind pro‐apoptotic proteins, such as BAK and BAX. BCL‐2 and BCL‐XL are the primary targets of ABT‐263 in cancer cells.
ABT 263 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 241)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7621 | 58 | Inquiry |
Related articles
- ABT 263: pharmacokinetic, activities and clinical applications
- ABT 263 is a potent and orally bioavailable inhibitor of Bcl-2 family proteins, showing promise in treating hematological and ....
- Dec 6,2023
- ABT-263
- Navitoclax, also known as ABT-263 and ABT 263, is a potent, oral biologically active inhibitor of the Bcl-2 protein family, ac....
- Oct 28,2021
923564-51-6(ABT 263)Related Search:
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4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
ABT 263
BenzaMide, 4-(4-((2-(4-chlorophenyl)-5,5-diMe
Benzamide, 4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-N-((4-(((1R)-3-(4-morpholinyl)-1-((phenylthio)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)-
ABT-263,Navitoclax
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ABT 263
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
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ABT263;ABT-263
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CS-1871
CS-1967
(R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide
NAVITOCLAX;ABT 263;ABT263
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ABT 263, 98%, potent inhibitor of Bcl-xL,Bcl-2 and Bcl-w
(R)-4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[3-morpholino-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
ABT 263 USP/EP/BP
Navitoclax-D8
Navitoclax
Navitoclax (ABT-263)
ABT-263(Navitoclax)/ABT263
(R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide
923564-51-6
23564-51-6
C47H55ClF3N5O6S3
Inhibitor
Apis
Chiral Reagents
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds