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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Apoptosis >Bcl-2 inhibitors >ABT-199

ABT-199

ABT-199 Structure
CAS No.
1257044-40-8
Chemical Name:
ABT-199
Synonyms
Venetoclax;Venclexta;ATB199;4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]ami;GDC-0199;Venetoclax (ABT-199, GDC-0199);2-(1H-Pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methy;4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide;4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide ABT-199 (GDC-0199);S8048
CBNumber:
CB62645962
Molecular Formula:
C45H50ClN7O7S
Molecular Weight:
868.44
MOL File:
1257044-40-8.mol
MSDS File:
SDS
Modify Date:
2024/7/25 20:04:46
Request For Quotation

ABT-199 Properties

Melting point >150°C (dec.)
Density 1.340±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly)
form Yellow solid.
pka 4.09±0.10(Predicted)
color Light Yellow to Yellow
InChIKey LQBVNQSMGBZMKD-UHFFFAOYSA-N
SMILES C(NS(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)(=O)=O)(=O)C1=CC=C(N2CCN(CC3CCC(C)(C)CC=3C3=CC=C(Cl)C=C3)CC2)C=C1OC1=CN=C2NC=CC2=C1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H361-H372
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501
NFPA 704
0
2 0

ABT-199 Chemical Properties,Uses,Production

Description

Venetoclax, codeveloped by AbbVie (previously Abbott Laboratories) and Genentech/ Roche, was approved in the US for treatment of patients with chronic lymphocytic leukemia (CLL). To meet qualifications for venetoclax treatment, patients must have received prior therapy and possess the 17p deletion genetic mutation, as determined by USFDA testing. Venetoclax functions as a selective inhibitor of B cell lymphoma subtype 2 (BCL-2), which is often overexpressed on malignant cells and thus leads to impairment of the apoptotic pathway. Along these lines, the orally dosed small molecule drug restores the ability of malignant cells to undergo apoptosis as its mechanism of action.90 Although other BCL-2 inhibitors are known, development of similar agents such as navitoclox have been pursued and halted due to undesired inhibition of BCL-XL, leading to significant thrombocytopenia and demonstrating the need for more selective inhibitors. Venetoclax is also currently being considered for approval in Europe and Canada for similar indications and is in various stages of development for the treatment of non-Hodgkin lymphomas (NHL), acute myeloid leukemia (AML), multiple myeloma (MM), and several other disorders, either as a combination therapy or a stand-alone treatment.

Definition

ChEBI: A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.

ABT-199 Preparation Products And Raw materials

Raw materials

3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid

Preparation Products

ABT-199 Suppliers

Global( 448)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Basil Drugs AND Pharmaceuticals Pvt Ltd +91-2249700250 +91-9619320820 Mumbai, India 108 58 Inquiry
Salvavidas Pharmaceutical Pvt., Ltd. +91-2612538898 +91-9327127459 Gujarat, India 34 58 Inquiry
MSN LABORATORIES PRIVATE LTD +91 40 30438600 New Delhi, India 230 58 Inquiry
DR REDDYS LABORATORIES LTD +91-40-49002900 New Delhi, India 201 58 Inquiry
ALEMBIC PHARMACEUTICALS LTD +91 40 23704923 / 24 / 25 New Delhi, India 108 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Supplier Advantage
Dr. Reddy's Laboratories Ltd 58
Alembic Pharmaceuticals Limited 58
Basil Drugs AND Pharmaceuticals Pvt Ltd 58
Salvavidas Pharmaceutical Pvt., Ltd. 58
MSN LABORATORIES PRIVATE LTD 58
DR REDDYS LABORATORIES LTD 58
ALEMBIC PHARMACEUTICALS LTD 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58

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  • Venetoclax, sold under the brand names Venclexta and Venclyxto, is a medication used to treat adults with chronic lymphocytic ....
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ABT-199 Spectrum

ABT-199(1257044-40-8)1HNMR

1257044-40-8(ABT-199)Related Search:

THJ-018 Osimertinib mesylate Vipadenant Venlafaxine PLX4032
2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]- Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 2-(3-fluorophenyl)-3-methylmorpholine(3-fluorophenmetrazine)(3-FPM) ADB-FUBINACA 4-Ethylmethcathinone Bortezomib
ABT 737 Trametinib ABT 263
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ABT-199 ABT-199 (GDC-0199);GDC-0199 ABT-199 100MG 2-(1H-Pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)met ABT-199, Venetoclax GDC 0199 GDC0199 Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)- ABT 199 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)phenylsulfonyl)benzamide 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide Venetoclax (ABT-199) 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl] ABT199,GDC0199 ABT-199, >=98% 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1 -yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (Venetoclax)(ABT199) Venclexta(abt199) ABT-199, Venetoclax, GDC-0199 ABT-199 (GDC-0199)Venetoclax ABT199; GDC0199;ABT 199;GDC 0199;GDC-0199 CS-679 105148 ABT199;GDC0199;ABT 199;GDC 0199;GDC-0199;VENETOCLAX D00PBX rg7601 S8048 W-6008 X3609 Z-3166 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (Venetoclax) 99%) (Venetoclax) ABT 199 (> ABT-199 USP/EP/BP Venetoclax trifluoroacetate salt ABT 199 (>99%) (Venetoclax) 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-e n-1-yl]methyl}piperazin-1-yl)-N-(3-nitro-4-{[(oxan-4 -yl)methyl]amino}benzenesulfonyl)-2-{1H-pyrrolo[ 2,3-b]pyridin-5-yloxy}benzamide 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohexy-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)phenylsuflonyl)benzamide Venetoclax 95% 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide ABT-199 (GDC-0199) Venetoclax 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]ami Venclexta ATB199 Venetoclax (ABT-199, GDC-0199) 2-(1H-Pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methy D torah GDC-0199 BT-199 bioavailable,orally,Venetoclax,inhibit,Inhibitor,Bcl-2 Family,GDC0199,GDC 0199,Autophagy Venetoclax ABT199 ABT-199 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide Venetola 1257044-40-8 257044-40-8 C45H50ClN7O7S Inhibitors