3-chloro-4-(pyridin-2-ylmethoxy)aniline
- CAS No.
- 524955-09-7
- Chemical Name:
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline
- Synonyms
- 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;AKOS B033273;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;UKRORGSYN-BB BBV-019513;Neratinib Intermediate1;AKOS B033273(524955-09-7)
- CBNumber:
- CB4801557
- Molecular Formula:
- C12H11ClN2O
- Molecular Weight:
- 234.68
- MOL File:
- 524955-09-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/10 8:42:08
| Melting point | 91.0 to 95.0 °C |
|---|---|
| Boiling point | 402.5±35.0 °C(Predicted) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.88±0.10(Predicted) |
| color | White to Light yellow to Light orange |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
3-chloro-4-(pyridin-2-ylmethoxy)aniline price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | C3150 | 3-Chloro-4-(2-pyridylmethoxy)aniline min. 98.0 % | 524955-09-7 | 1G | ₹9000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3150 | 3-Chloro-4-(2-pyridylmethoxy)aniline min. 98.0 % | 524955-09-7 | 5G | ₹26500 | 2022-05-26 | Buy |
3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Uses,Production
Uses
3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.
Synthesis
3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL).
The mixture was stirred at 60° C. overnight.
Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate.
The organic phase was separated, washed with saturated brine and dried.
The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained.
1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +8613916485955 | Rajasthan, India | 145 | 58 | Inquiry |
| Pratap Organics Pvt Ltd | +91 9920018682 +91 9152015164 | Maharashtra, India | 122 | 58 | Inquiry |
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| ALTAIR ALCHEMY Laboratories | 91--9014276848 | Hyderabad, India | 324 | 58 | Inquiry |
| Pratap Organics Pvt. Ltd. | 08048372580Ext 173 | Mumbai, India | 87 | 58 | Inquiry |
| AARTI INDUSTRIES LIMITED | 912267976666 | New Delhi, India | 172 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
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